A5001437430- Inhalation and Respiratory Drug Delivery
- Aerosol Filtration and Electrostatic Precipitation
- Neonatal Respiratory Health Research
- Microencapsulation and Drying Processes
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Combustion and Detonation Processes
- Neuroscience of respiration and sleep
- Cyclone Separators and Fluid Dynamics
- Cystic Fibrosis Research Advances
- Refrigeration and Air Conditioning Technologies
- Particle Dynamics in Fluid Flows
- Airway Management and Intubation Techniques
- Infant Nutrition and Health
- Infection Control and Ventilation
- Vibrio bacteria research studies
- Gas Dynamics and Kinetic Theory
- Nosocomial Infections in ICU
- Color Science and Applications
- Respiratory and Cough-Related Research
- Drug Solubulity and Delivery Systems
- Acoustic Wave Resonator Technologies
- Advanced Sensor and Energy Harvesting Materials
- Granular flow and fluidized beds
- Plasma and Flow Control in Aerodynamics
Virginia Commonwealth University
2015-2025
Abstract The administration of surfactant aerosol therapy to preterm infants receiving continuous positive airway pressure (CPAP) respiratory support is highly challenging due small flow passages, relatively high ventilation rates, rapid breathing and inhalation volumes. To overcome these challenges, the objective this study was implement a validated computational fluid dynamics (CFD) model develop an overlay nasal prong interface design for use with CPAP that enables efficiency powder...
Abstract Purpose To improve the quality of aerosol delivery to infants, iDP-ADS was advanced include dual-prong nose-to-lung administration with a bifurcating interface, consistently monitor lung pressures and control ventilatory parameters pressure monitoring (PMC) unit, implement flexible nasal prongs for use across range subject sizes. Methods Four flow pathways were integrated into tested in vitro full-term infant nose-throat (NT) model comparison performance single-prong interface....
Delivering aerosols to the lungs through nasal route has a number of advantages, but its use been limited by high depositional loss in extrathoracic airways. The objective this study was evaluate nose-to-lung (N2L) delivery excipient enhanced growth (EEG) formulation generated with new inline dry powder inhaler (DPI). device also adapted enable aerosol patient simultaneously receiving respiratory support from flow cannula (HFNC) therapy.The delivered antibiotic ciprofloxacin, which...
Pharmaceutical aerosol systems present a significant challenge to computational fluid dynamics (CFD) modeling based on the need capture multiple levels of turbulence, frequent transition between laminar and turbulent flows, anisotropic particle dispersion, near-wall transport phenomena often within geometrically complex over time scales. Two-equation turbulence models, such as k−ω family approximations, offer computationally efficient solution approach, but are known require use (NW)...
Improving the deep lung delivery of aerosol surfactant therapy (AST) with a dry powder formulation may enable significant reductions in dose while providing improved efficacy. The objective Part I this two-part study was to present development new synthetic (SLS) product and characterize performance based on formation realistic vitro airway testing leading recommendations for subsequent vivo animal model experiments.
Inline dry powder inhalers (DPIs) are actuated by an external air source and have distinct advantages for delivering aerosols to infants children, individuals with compromised lung function or who require ventilator support. However, current inline DPIs either perform poorly, difficult operate, and/or large volumes (∼1 L) of air. The objective this study was develop characterize a new DPI aerosolizing spray-dried formulations masses 10 mg higher using dispersion volume mL per actuation that...
Background: Dry powder inhalers (DPIs) offer a number of advantages, such as rapid delivery high-dose inhaled medications; however, DPI use in children is often avoided due to low lung efficiency and difficulty operating the device. The objective this study was develop high-efficiency inline for administering aerosol therapy with option using either an oral or trans-nasal approach. Methods: An developed that consisted hollow inlet outlet capillaries, chamber, nasal interface. A ventilation...
Momentum transfer from nasal spray droplets to the surrounding gas may create droplet cloud motion and influence deposition patterns. The objective of this study was develop a validated computational fluid dynamics (CFD) model for two different spray-pump designs that includes effects (i.e. two-way coupling) in computationally efficient manner. Spray transport were simulated an average adult airway (that captures drug delivery) using both coupled one-way Euler-Lagrange frameworks. CFD...
Pulmonary deposition of lung-targeted therapeutic aerosols can achieve direct drug delivery to the site action, thereby enhancing efficacy and reducing systemic exposure. In this study, we investigated in vitro vivo aerosol performance novel small animal air-jet dry powder insufflator (Rat AJ DPI) using spray-dried albuterol excipient-enhanced-growth (EEG) as a model formulation. The aerosolization optimized EEG was first assessed Rat DPI. DPI deliver rat lungs then compared that...