A5071839543- Inhalation and Respiratory Drug Delivery
- Neonatal Respiratory Health Research
- Microencapsulation and Drying Processes
- Drug Solubulity and Delivery Systems
- Respiratory Support and Mechanisms
- Cystic Fibrosis Research Advances
- Pneumonia and Respiratory Infections
- Aerosol Filtration and Electrostatic Precipitation
- Neuroscience of respiration and sleep
- Essential Oils and Antimicrobial Activity
- Particle Dynamics in Fluid Flows
- Analytical Methods in Pharmaceuticals
- Asthma and respiratory diseases
- Cyclone Separators and Fluid Dynamics
- Ethnobotanical and Medicinal Plants Studies
- Analytical Chemistry and Chromatography
- Psidium guajava Extracts and Applications
- Antibiotics Pharmacokinetics and Efficacy
- Natural Antidiabetic Agents Studies
- Advanced Drug Delivery Systems
- Seed and Plant Biochemistry
- Gas Dynamics and Kinetic Theory
- Chemical Synthesis and Reactions
- Infant Nutrition and Health
- Phytochemistry and biological activity of medicinal plants
Virginia Commonwealth University
2019-2025
University of Otago
2016-2021
Jahangirnagar University
2012-2013
East West University
2012
North South University
2012
Abstract The administration of surfactant aerosol therapy to preterm infants receiving continuous positive airway pressure (CPAP) respiratory support is highly challenging due small flow passages, relatively high ventilation rates, rapid breathing and inhalation volumes. To overcome these challenges, the objective this study was implement a validated computational fluid dynamics (CFD) model develop an overlay nasal prong interface design for use with CPAP that enables efficiency powder...
To investigate the phytochemical screening (group determination) and selected pharmacological activities (antioxidant, antimicrobial analgesic activity) of plant Sida cordifolia Linn (S. cordifolia).
Abstract Purpose To improve the quality of aerosol delivery to infants, iDP-ADS was advanced include dual-prong nose-to-lung administration with a bifurcating interface, consistently monitor lung pressures and control ventilatory parameters pressure monitoring (PMC) unit, implement flexible nasal prongs for use across range subject sizes. Methods Four flow pathways were integrated into tested in vitro full-term infant nose-throat (NT) model comparison performance single-prong interface....
Bedaquiline is a newly developed anti-tuberculosis drug, conditionally approved by the United States Food and Drug Administration (USFDA) for treating drug-resistant tuberculosis in adults. Oral delivery of bedaquiline causes severe side effects such as increased hepatic aminotransferase levels cardiac arrhythmias (prolongation QT-interval). This study aimed to develop inhalable dry powder particles with high aerosolization efficiency reduce side-effects oral bedaquiline. (with or without...
Pharmaceutical aerosol systems present a significant challenge to computational fluid dynamics (CFD) modeling based on the need capture multiple levels of turbulence, frequent transition between laminar and turbulent flows, anisotropic particle dispersion, near-wall transport phenomena often within geometrically complex over time scales. Two-equation turbulence models, such as k−ω family approximations, offer computationally efficient solution approach, but are known require use (NW)...
Improving the deep lung delivery of aerosol surfactant therapy (AST) with a dry powder formulation may enable significant reductions in dose while providing improved efficacy. The objective Part I this two-part study was to present development new synthetic (SLS) product and characterize performance based on formation realistic vitro airway testing leading recommendations for subsequent vivo animal model experiments.
Background: An infant air-jet dry powder inhaler (DPI) platform has recently been developed that in combination with highly dispersible spray-dried formulations can achieve high-efficiency aerosolization low actuation air volumes. The objective of this study was to investigate modifications the nasal interface section improve aerosol delivery performance through preterm nose–throat (NT) models. Methods: Aerosol multiple flow pathways and prong configurations assessed two vitro NT Two...
This study aimed to develop a combination dry powder formulation of ethionamide and moxifloxacin HCl as this is synergistic against drug-resistant Mycobacterium tuberculosis (Mtb). L-leucine (20% w/w) was added in the formulations maximize process yield. Moxifloxacin and/or powders with/without were produced using Buchi Mini Spray-dryer. A next generation impactor used determine vitro aerosolization efficiency. The also characterized for other physicochemical properties cytotoxicity. All...
The objective of this study was to characterize the effects multiple nasal prong interface configurations on depositional loss pharmaceutical aerosols in a preterm infant nose-throat (NT) airway model. Benchmark vitro experiments were performed which spray-dried powder formulation delivered new NT model with positive-pressure air-jet dry inhaler using single- and dual-prong interfaces. These results used develop validate computational fluid dynamics (CFD) aerosol transport deposition...
A reversed phase high performance liquid chromatography (RP-HPLC) method for the simultaneous quantification of bedaquiline (TMC207), moxifloxacin and pyrazinamide in a pharmaceutical powder formulation inhalation has been developed validated. The was simply dissolved methanol analytes separated run time 20 min on Luna C18 (2) (150 × 4.6 mm, 5 µm) column using gradient elution with triethylamine phosphate buffer (pH 2.5) delivered at 1.2 mL/min. detection (with retention time) carried out...
Background: In neonatal respiratory distress syndrome, breathing support and surfactant therapy are commonly used to enable the alveoli expand. Surfactants typically delivered through liquid instillation. However, instillation does not specifically target small airways. We have developed an excipient enhanced growth (EEG) powder aerosol formulation using Survanta®. Methods: EEG Survanta was a novel dry inhaler via tracheal insufflation depleted rats at nominal doses of 3, 5, 10, 20 mg...