A5004801351- Immunotherapy and Immune Responses
- vaccines and immunoinformatics approaches
- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
- Polyomavirus and related diseases
- Chemokine receptors and signaling
- Cancer Treatment and Pharmacology
- Xenotransplantation and immune response
- Angiogenesis and VEGF in Cancer
- Cancer, Lipids, and Metabolism
- Algal biology and biofuel production
- Photodynamic Therapy Research Studies
- Cancer Research and Treatments
- Bacteriophages and microbial interactions
- SARS-CoV-2 and COVID-19 Research
- Parasitic infections in humans and animals
Islamic Azad University, Science and Research Branch
2018-2021
Isfahan University of Medical Sciences
2019
Recently, cancer immunotherapy has gained lots of attention to replace the current chemoradiation approaches and multi-epitope vaccines are manifesting as next generation immunotherapy. Therefore, in this study, we used multiple immunoinformatics along with other computational design a novel vaccine against breast cancer. The most immunogenic regions BORIS cancer-testis antigen were selected according binding affinity MHC-I II molecules well containing cytotoxic T lymphocyte (CTL) epitopes...
In our previous study, immunoinformatic tools were used to design a novel multiepitope cancer vaccine based on the most immunodominant regions of BORIS cancer-testis antigen. The final construct was an immunogenic, non-allergenic, and stable protein consisted multiple cytotoxic T lymphocytes epitopes, IFN-γ inducing B cell epitopes according bioinformatic analyzes. Herein, DNA sequence placed into pcDNA3.1 vector as (pcDNA3.1-VAC). Also, recombinant peptide (MPV) produced by transfected BL21...
Abstract Different chemical and nanomaterial agents have been introduced for radiosensitizing purposes. However, many researchers believe these are far away from clinical application due to side effects limited knowledge about their behavior in the human body. In this study, C-phycocyanin (C-PC) was used as a natural radiosensitizer enhancement of radiation therapy (RT) efficacy. C-PC treatment’s effect on COX-2 expression cancer cells investigated by flow cytometry, western blot, qRT-PCR...
Multiepitope cancer vaccines have gained lots of attention for prophylactic and therapeutic purposes in patients. In our previous study, multiepitope DNA peptide consisted the most immunodominant epitopes ACRBP SYCP1 antigens were designed by bioinformatic tools. this effect co-immunization with these 4T1 breast animal model was assessed. Serum levels peptide-specific IgG total, IgG2a IgG1 measured enzyme-linked immunosorbent assay (ELISA). Also, efficacy immunized mice splenocytes'...
Spirulina platensis extracts have exhibited considerable anti‐cancer effects. To investigate the efficacy of extract enriched for Braun‐type lipoprotein (Immulina®) breast cancer treatment, 4T1 tumor‐bearing mice were treated with 40 mg/kg Immulina® daily and tumors' growth metastasis assessed. Also, CD4, CD8, CD56 staining performed to effect on immune cells' recruitment tumors by immunohistochemistry. could significantly ( P < 0.001) inhibit growth. Immulina®‐treated group a 63%...
Background: The hydatid cyst fluid antigens have high homology with cancer cell and also exhibit considerable immunogenicity. Therefore, their utilization for immunization can cause an effective antitumor immune response. However, the main challenge is identifying most this purpose. Methods: Hydatid fractions including glycolipid fraction, glycoprotein 78 kDa antigen B fraction were prepared. Then, BALB/c mice immunized against different and, subsequently, 4T1 cells subcutaneously implanted....