A5102951003- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Inflammatory Bowel Disease
- Microscopic Colitis
- Pharmacological Effects of Natural Compounds
- Pathogenesis and Treatment of Hiccups
- Clostridium difficile and Clostridium perfringens research
- Cytokine Signaling Pathways and Interactions
Cambridge University Hospitals NHS Foundation Trust
2019-2025
Abstract Background Intravenous corticosteroids remain the cornerstone of initial management ASUC. Methylprednisolone and hydrocortisone are two commonly used intravenous (IV) steroids recommended in guidelines.1 has less frequent dosing requirements is reported to have weaker mineralocorticoid effects compared hydrocortisone, theoretically reducing risk hypokalaemia.2 Comparative data on efficacy safety drugs ASUC lacking. In IASO trial patients with were randomised receive IV according...
Abstract Background Acute severe ulcerative colitis (ASUC) is a manifestation of (UC) that requires hospitalisation. Despite significant advances in therapeutic options for UC and the medical management steroid-refractory ASUC, initial treatment paradigm ASUC has not changed since 1950s based on use intravenous (IV) corticosteroids. Approximately 50% patients do respond require further or surgical therapy. Interleukin 1 (IL-1) been identified as key mediator colonic inflammation plays...
Background Chronic subdural haematoma is a collection of ‘old blood’ and its breakdown products in the space predominantly affects older people. Surgical evacuation remains mainstay management symptomatic cases. Objective The Dex-CSDH (DEXamethasone SubDural Haematoma) randomised trial investigated clinical effectiveness cost-effectiveness dexamethasone patients with chronic haematoma. Design This was parallel, superiority, multicentre, pragmatic, controlled trial. Assigned treatment...