A5100712781- Orthopaedic implants and arthroplasty
- Hepatocellular Carcinoma Treatment and Prognosis
- Hip disorders and treatments
- Hip and Femur Fractures
- Metabolism, Diabetes, and Cancer
- Pregnancy and preeclampsia studies
- Lung Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Lung Cancer Treatments and Mutations
- Plant Pathogenic Bacteria Studies
- Reproductive System and Pregnancy
- Lung Cancer Research Studies
- Bone and Joint Diseases
- Cancer, Lipids, and Metabolism
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Immunotherapy and Biomarkers
- Renal Diseases and Glomerulopathies
- Infections and bacterial resistance
- Nasolacrimal Duct Obstruction Treatments
- Microbial Applications in Construction Materials
- Bone fractures and treatments
- Phytochemistry and biological activity of medicinal plants
- Transactional Analysis in Psychotherapy
- Congenital gastrointestinal and neural anomalies
- Anesthesia and Pain Management
Peking University
2015-2025
Peking University First Hospital
2015-2025
Ministry of Education of the People's Republic of China
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Affiliated Hospital of North Sichuan Medical College
2024
Weatherford College
2024
Beijing Tongren Hospital
2023-2024
Capital Medical University
2023-2024
National Quality Inspection and Testing Center for Surveying and Mapping Products
2023
China Medical University
2022
Hepatocellular carcinoma (HCC) is a male‐dominant cancer, and androgen receptor (AR) has been linked to the pathogenesis of HCC. However, AR expression its precise role in HCC remain controversial. Moreover, previous antiandrogen anti‐AR clinical trials failed demonstrate benefits. In this study, we found that overexpressed nucleus approximately 37% tumors, which significantly associated with advanced disease stage poor survival. overexpression cells markedly alters AR‐dependent...
Insufficient autophagy in podocytes is related to podocyte injury diabetic nephropathy (DN). Advanced glycation end-products (AGEs) are major factors of DN. However, the role and mechanism AGEs autophagic dysfunction remain unknown. We investigated flux AGE-stimulated cultured using multiple assays: western blotting, reverse transcription-quantitative PCR, immunofluorescence staining, electron microscopy. also utilized chloroquine a fluorescent probe monitor formation turnover...
Renal red blood cell casts (RBCC) are common in IgA nephropathy (IgAN), but their role kidney disease progression of patients with IgAN remains unclear. 1425 Peking University First Hospital (PKU-IgAN) cohort and 279 TESTING trial were enrolled to test the association between RBCC outcome. was defined as positive (+) when at least one cast identified within renal tubules by light microscopy. Kidney endpoint composite first occurrence a sustained 30% decrease estimated glomerular filtration...
Early stage diabetic nephropathy is characterized by elevated glomerular filtration. Recent studies have identified high-glucose induced p38 MAPK (p38) over-activation in mesangial cells. Mesangial hypocontractility the major underlying mechanism, however, no ameliorating agents are currently available. We investigated protective effects of emodin on cell hypocontractility. cells were cultured under normal (5.6 mM) and high glucose (30 conditions. Emodin was administrated at doses 50 mg/l...
Background Focal segmental glomerulosclerosis (FSGS) lesions are similar in characteristics to S of the Oxford classification IgA nephropathy (IgAN) and may predict poor prognosis. In present study, we aimed explore association between plasma soluble urokinase receptor (suPAR) levels podocytes damage IgAN patients. Methods We enrolled 569 patients with follow-up data detected suPAR at renal biopsy by enzyme-linked immunosorbent assay. Results Plasma or without did not differ significantly (P...
Plasma levels of soluble factors early during hepatocellular carcinoma (HCC) stereotactic body radiotherapy (SBRT) were evaluated in relation to radiation liver injury, tumor response, and risk death. No significant differences found baseline plasma AFP, CXCL1, HGF amongst HCC patients with different Child Pugh scores. Higher sTNFRII (P < 0.001), lower sCD40L 0.001) CXCL1 = 0.01) following one two fractions SBRT noted who developed toxicity vs. those did not. High circulating AFP (HR 2.16, P...
Abstract Background: After neoadjuvant chemotherapy (NAC), non-pathological complete response of breast cancer patients can benefit from tailored adjuvant chemotherapy. However, it is difficult to select with poorer prognosis for additional maximize the benefits. Our study aimed explore whether subtypes tumor-infiltrating lymphocytes (TILs) in residual tumors (RT) related triple-negative (TNBC) after NAC. Methods: Data primary TNBC consecutively diagnosed at Breast Disease Center Peking...
Dietary and symbiotic bacteria can exert powerful influence on metazoan lipid metabolism. Recent studies have emerged that microbiota a role in animal obesity related health disorders, but the mechanisms by which storage their host are unknown. To reduce complexity of relationship between gut host, Caenorhabditis elegans (C. elegans) has been chosen as model organism to study interspecies interaction. Here, we demonstrate feeding C. with an opportunistic pathogenic bacterium Stenotrophomonas...
Bernese periacetabular osteotomy ( PAO ) has several advantages dealing with adolescents and adults acetabular dysplasia. The authors introduced the details steps performing , attached video schematic diagram which demonstrates a perfect in efficiency accuracy. patient is an 18‐year‐old girl, complaining hip pain on left side for 6 months. Physical examination shows normal gait range of motion ROM hip. Pelvic anteroposterior X ‐ray dysplasia left, post operation right. She very satisfied...
(1) Background: Neoadjuvant therapy is the main therapeutic strategy for human epidermal growth factor receptor 2 (HER2)-positive breast cancer patients, and combination of trastuzumab pertuzumab (HP) has become a routine treatment. How to predict screen patients who are less likely respond neoadjuvant focus research. The androgen (AR) biomarker that widely expressed in all subtypes probably related treatment response prognosis. In this study, we investigated relationship between AR...
This study aims to develop and validate a predictive nomogram for severe postoperative pleural effusion (SPOPE) in patients undergoing hepatectomy liver cancer. A total of 536 cancer who underwent at the Department Hepatobiliary Surgery I Affiliated Hospital North Sichuan Medical College from January 1, 2018, December 31, 2022, were enrolled retrospective observational comprised training dataset. Lasso regression logistic analyses employed construct nomogram. The was internally validated...
Background Different feasible and safe thrombectomy distal protection devices have been used in clinical practice. The efficiency safety of adjunct using Diver CE device (Invatec, Italy) versus Guardwire Plus (Medtronic, USA) before percutaneous coronary intervention (PCI) were compared patients with acute inferior ST-segment-elevation myocardial infarction (STEMI) for less than 12 hours, thrombolysis (TIMI) flow grade 0 to 1, total occlusion the proximal right artery (≥=3 mm diameter) a...
Abstract Background Ligneous conjunctivitis (LC) is a rare inflammatory lesion of the conjunctiva with an unknown etiology. It easily confused lymphoma or other diseases in clinical diagnosis, and very difficult to treat. Case presentation We presented 41-year-old female patient bilateral conjunctival masses for more than six months. The had no contributory history ocular trauma, family tumor drug allergy. Taking patient’s pathological features together, we considered this was case IgG4 +...
To observe the effect of rosiglitazone (RGZ) and all-trans-retinoic acid (ATRA) on growth myeloma xenograft in nude mice to explore influence RGZ ATRA VEGF expression angiogenesis tumor.VEGF gene cell line U266 cells was analyzed by semi-quantitative RT-PCR after incubation with RGZ, ATRA, or + for 24 h. Myeloma established subcutaneous injection 10(7) scapula area 4-week old mice. 7 days later, were administered respectively, intraperitoneal once every day 21 days. The control given equal...