A5007160664- Multiple Myeloma Research and Treatments
- Pharmacological Effects and Toxicity Studies
- Nausea and vomiting management
- Head and Neck Cancer Studies
- Childhood Cancer Survivors' Quality of Life
- Cancer survivorship and care
- Global Cancer Incidence and Screening
- Cancer Diagnosis and Treatment
- Women's cancer prevention and management
- Thyroid Cancer Diagnosis and Treatment
- Palliative and Oncologic Care
- Peptidase Inhibition and Analysis
- Neuroblastoma Research and Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Neuroendocrine Tumor Research Advances
- Alkaloids: synthesis and pharmacology
- Breast Cancer Treatment Studies
- Lung Cancer Diagnosis and Treatment
- Leprosy Research and Treatment
- Cancer Risks and Factors
- Lung Cancer Treatments and Mutations
- Palliative Care and End-of-Life Issues
- Anesthesia and Pain Management
- Science and Science Education
- Economic and Financial Impacts of Cancer
Johnson & Johnson (Sweden)
2023
Janssen (Belgium)
2023
Faculdade de Medicina do ABC
2007-2019
Centro Universitário Padre Anchieta
2015
Instituto Brasileiro de Controle do Câncer
2014
Fundação do ABC
2006-2014
Hospital Israelita Albert Einstein
2007-2008
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2006
The immunohistochemistry technique is used in the search for cell or tissue antigens that range from amino acids and proteins to infectious agents specific cellular populations. comprises two phases: (1) slides preparation stages involved reaction; (2) interpretation quantification of obtained expression. Immunohistochemistry an important tool scientific research also a complementary elucidation differential diagnoses which are not determinable by conventional analysis with hematoxylin...
To identify potential delays in the management of patients with breast cancer examined at a public hospital, from time suspicion until diagnosis and beginning treatment.Retrospective study which analyzed data related to elapsed different intervals between suspicion, onset systemic cancer-directed treatments, consecutive cared for medical oncology clinic Mario Covas Hospital during 2006.Sixty-eight women, mean age 56.3 years (standard deviation: 12.2 years), were included. Of all intervals,...
Context and objective: Guaraná (Paullinia cupana) has been used medicinally for centuries. The aim of this study is evaluate the effectiveness guaraná in treatment postradiation depression fatigue. Design setting: This had a double-blind randomized design with crossover between experimental arms, at Faculdade de Medicina da Fundação do ABC. Methods: We conducted trial 36 patients breast cancer undergoing adjuvant radiation therapy. to either 75 mg daily p.o. or placebo. Patients were...
To assess which laboratory and clinical factors are associated with fatigue in patients terminal cancer.We evaluated 51 advanced incurable solid tumors using the Chalder Fatigue Questionnaire (CFQ) Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) scale for fatigue; Pittsburgh Sleep Quality Index (PSQI-BR) sleep quality; Hospital Anxiety Depression Scale (HADS) anxiety depression; European Organization Research Treatment Cancer (EORTC) Core Life Questionnaire, Version 3.0...
Real-world evidence on non-Hodgkin lymphoma (NHL) management in Latin America is currently lacking. The objective of this study was to describe treatment characteristics and outcomes NHL America.A total 2,967 patients with aggressive indolent subtypes, including diffuse large B-cell (DLBCL), follicular (FL), mantle-cell (MCL), mucosa-associated lymphoid tissue (MALT) lymphoma, incident or prevalent diagnosis between 2006 2015, were retrospectively identified using clinical charts registered...
Fatigue is a common symptom in cancer patients receiving radiation therapy.We conducted double-blind randomized crossover trial of multivitamins versus placebo with breast undergoing therapy to evaluate fatigue and quality life.: We 40 either or Centrum Silver. At the middle treatments, were switched from vice versa. Patients answered EORTC QLQ C-30 life (QOL) Chalder questionnaires at beginning, middle, end therapy. Both groups experienced decreases general (P = 0.009; P 0.001) physical...
Cat's claw (Uncaria tomentosa) is a native Amazon plant that exhibits anti-inflammatory and antitumor properties. We wanted to assess its activity for symptom management of terminal cancer patients.This prospective phase II study assessed the effects 100-mg dose dry extract U. tomentosa three times per day in patients with advanced solid tumors who had no further therapeutic options life expectancy at least 2 months. The European Organization Research Treatment Cancer Quality Life...
to evaluate if time between surgery and the first adjuvant treatment (chemotherapy, radiotherapy or hormone therapy) in patients with breast cancer is a risk factor for lower overall survival (OS).data from five-year retrospective cohort study of all women diagnosed invasive at an academic oncology service were collected analyzed.three hundred forty-eight consecutive included. Time was shorter (HR=1.3, 95CI 1.06-1.71, p=0.015), along negative estrogen receptor, presence lymphovascular...
Introduction The search for a specific marker that could help to distinguish between differentiated thyroid carcinoma and benign lesions remains elusive in clinical practice. Heparanase (HPSE) is an endo-beta-glucoronidase implicated the process of tumor invasion, heparanase-2 (HPSE2) modulates HPSE activity. aim this study was evaluate role heparanases development differential diagnosis follicular pattern lesions. Methods HPSE2 expression by qRT-PCR, immunohistochemistry evaluation, western...
CONTEXT AND OBJECTIVE: Nausea and vomiting are major inconveniences for patients undergoing chemotherapy. Despite standard preventive treatment, chemotherapy-induced nausea (CINV) still occurs in approximately 50% of these patients. In an attempt to optimize this we evaluated the possible effects carbamazepine prevention CINV.DESIGN LOCATION: Prospective nonrandomized open-label phase II study carried out at a Brazilian public oncology service. METHODS: Patients allocated their first cycle...
Objective To evaluate the perception of oncology patients and their caregivers upon diagnosis beginning therapy during palliative care.Methods A cross-sectional study at care outpatients clinics Faculdade de Medicina do ABC. Clinical demographic data from were collected questionnaires regarding elements considered important in relation to treatment applied.Results We enrolled 32 23 that initiating outpatient clinic, as well 20 clinic. Regarding treated issues most a physician available...
To define a predictive factor for pathologic complete response, compare the oncologic outcomes associated with degree of response after neoadjuvant chemotherapy, and to analyze as prognostic overall survival progression-free survival.A retrospective study patients admitted Hospital Estadual Mário Covas Anchieta from 2008 2012, locally advanced breast cancer. Hormone receptor status, HER2 histologic nuclear grade, age upon diagnosis histological type tumor were analyzed. Pathologic evaluation...
To describe the epidemiological profile of patients with lung cancer treated at a public tertiary referral hospital specializing in oncology, and to explore variables that may be related overall survival (OS) these patients.Data from medical records all invasive consecutively seen Oncology Department Hospital Estadual Mário Covas between August 2008 December 2013 were extracted. The information obtained was submitted statistical analysis.Of total 210 patients, 39 excluded analysis due lack...
OBJETIVO: Examinar o impacto da razão entre linfonodos comprometidos e total de dissecados como fator prognóstico em pacientes com câncer cólon. MÉTODOS: Trata-se um trabalho retrospectivo, realizado por meio consulta dos prontuários cólon, consecutivos, provenientes três instituições localizadas no ABC paulista. De cada prontuário, foram extraídos dados demográficos relacionados à doença. Estatística descritiva regressão proporcional Cox utilizadas para descrever os resultados. RESULTADOS:...
Topic: 14. Myeloma and other monoclonal gammopathies - Clinical Background: The treatment landscape of Multiple (MM) has evolved in the last decade with approval many drugs different mechanisms action, improving patient survival1. However, low-resource regions such as Latin America (LA), access to novel therapies might be delayed, negatively impacting outcomes those patients2. Aims: MYLACRE study aimed describe MM population concerning demographics clinical characteristics profile LA...
In patients with essential thrombocythemia (ET), the vascular complications contribute to morbidity and mortality. To better predict occurrence of thrombotic events, an International Prognostic Score for Thrombosis in Essential Thrombocythemia (IPSET-thrombosis) has recently been proposed. We present application this score compare its results usual classification system.We retrospectively evaluated characteristics risk factors thrombosis 46 a diagnosis ET seen last 6 years at Faculdade de...
Relata-se o caso de uma paciente 60 anos, em menopausa há 14 com presença nódulo pulmonar à radiografia tórax diagnosticado no seguimento pós-operatório por neoplasia mama. A tinha história mastectomia e linfadenectomia axilar ipsilateral carcinoma ductal invasivo mama, assim como hormonioterapia, quimioterapia radioterapia adjuvante. Após nodulectomia vídeotoracoscopia, exame congelação mostrou tratar-se um hamartoma pulmonar. Estudos recentes demonstram que 75% dos pacientes se submeteram...
Chemoradiotherapy for squamous cell carcinoma of the oropharynx (SCCO) provides good results locoregional disease control, with high rates complete clinical and pathologic responses, mainly in neck.To determine whether response after chemoradiotherapy is related to prognosis patients SCCO.Data were prospectively extracted from records N2 N3 SCCO submitted a planned neck dissection chemoradiotherapy.A total 19 evaluated. Half obtained neck. Distant or recurrence occurred approximately 42%...
Daratumumab is a CD38-targeting monoclonal antibody with established efficacy and safety in patients relapsed or refractory multiple myeloma (RRMM). We report results of an early access protocol (EAP) daratumumab monotherapy for RRMM cohort Brazilian patients.Patients ≥3 prior lines therapy, including proteasome inhibitor (PI) immunomodulatory drug (IMiD), who were double to both PI IMiD received daratumumab, 16 mg/kg, intravenously weekly 8 weeks, biweekly every 4 weeks thereafter until...
Objective: To present a descriptive analysis of patients diagnosed with multiple myeloma, correlating it mortality. Methods: A retrospective study that analyzed consecutive myeloma under follow-up at the Faculdade de Medicina do ABC from 2006 to 2010. Results: The median age was 58.5 years. Anemia observed upon diagnosis in 87% patients, hypercalcemia 38%, and creatinine levels higher than 2 mg/dL 19%. M protein detected 85.7%. five-year survival rate 74.6%. Multivariate showed statistical...