A5017938191- Analytical Chemistry and Sensors
- Hydrogels: synthesis, properties, applications
- Electrochemical sensors and biosensors
- Advanced Sensor and Energy Harvesting Materials
- Electrospun Nanofibers in Biomedical Applications
- Microfluidic and Capillary Electrophoresis Applications
- Molecular Sensors and Ion Detection
- Dielectric materials and actuators
- Proteins in Food Systems
- Nanoplatforms for cancer theranostics
- Solar Thermal and Photovoltaic Systems
- Electrochemical Analysis and Applications
- Polydiacetylene-based materials and applications
- Nanocluster Synthesis and Applications
- Advanced Polymer Synthesis and Characterization
- SARS-CoV-2 detection and testing
- Wound Healing and Treatments
- Supramolecular Self-Assembly in Materials
- Electrowetting and Microfluidic Technologies
- Antimicrobial agents and applications
- Biosensors and Analytical Detection
- Advanced Chemical Sensor Technologies
- Photonic and Optical Devices
- Phytase and its Applications
- Luminescence and Fluorescent Materials
University of Alberta
2019-2024
Alberta Hospital Edmonton
2021
Stimuli-responsive polymers (SRPs) are capable of changing their solubility, conformation, and volume in response to external stimuli. Here, we detail how SRPs can be used for sensing actuation, focus on the mechanism.
Human mesenchymal stem cells (hMSCs), which have the ability to differentiate into osteoblasts, show promise for bone tissue engineering and defect treatment. While there are a number of approaches currently available accomplish this, e.g., utilizing biodegradable materials loaded with synthetic glucocorticoid osteogenic inducer dexamethasone (DEX), still many disadvantages current technologies. Here, we generated light-responsive microgels that showed capable loading releasing DEX in...
An approach to assess severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (and past infection) was developed. For virus detection, the SARS-CoV-2 nucleocapsid protein (NP) targeted. To detect NP, antibodies were immobilized on magnetic beads capture NPs, which subsequently detected using rabbit anti-SARS-CoV-2 and alkaline phosphatase (AP)-conjugated anti-rabbit antibodies. A similar used SARS-CoV-2-neutralizing antibody levels by capturing spike receptor-binding domain...
We developed a light-degradable nanocomposite hydrogel to achieve both controlled antibiotic delivery and degradation using light as the sole stimulus. They could serve novel materials for antibacterial wound dressing applications.
Stretchable poly(N-isopropylacrylamide)-co-acrylic acid (pNIPAm-co-10% AAc) microgel-based reservoir devices were fabricated and used to control the release rate of small molecule model drug tris(4-(dimethylamino)phenyl)methylium chloride (crystal violet, CV) solution by varying Au layer thickness coating microgels device elongation. Specifically, we showed that CV could be loaded into microgel via electrostatic interactions at pH 6.5, triggered upon exposure a 3.0 solution, which breaks...
Light- and temperature-responsive poly(N-isopropylacrylamide-co-nitrobenzyl methacrylate) (pNIPAm-co-NBMA) microgels were synthesized via free-radical precipitation polymerization exhibited a hydrodynamic diameter of 320 ± 40 nm. We demonstrated that the microgels' NMBA groups cleaved upon UV irradiation, which we showed could be used for light-activated release fluorescein (used as model drug molecule). Moreover, also promoted by microgel deswelling due to heating. Specifically, hydrophobic...
Abstract Fluorescent poly( N ‐isopropylacrylamide‐ co ‐Nile blue) (pNIPAm‐ ‐NB) microgels were synthesized that exhibited fluorescence intensity changes in a water temperature‐dependent fashion. NB is well known to exhibit depends on the hydrophobicity of environment, while pNIPAm‐based are transition from swollen (hydrophilic) collapsed (relatively hydrophobic) at temperatures greater than 32 °C; hence, we attribute above behavior with increasing temperature. This phenomenon ultimately due...
Plant-based food proteins are a promising choice for the preparation of nanoparticles (NPs) due to their high digestibility, low cost, and ability interact with various compounds nutrients. Moreover, nanoencapsulation offers potential solution protecting nutrients during processing enhancing bioavailability. This study aimed develop evaluate based on legumin/vicilin (LV) extracted from fava beans, goal encapsulating delivering model nutraceutical compound, folic acid (FA). Specifically, NPs...
Micro/nanogels are unique materials that exhibit the properties of both colloids and hydrogels, i.e. being they a large specific surface area, while hydrophilic porous allowing them to swell great degree with water. Engineering micro/nanogels, through rational design various polymer compositions and/or optical structures, can enable respond myriad stimuli, e.g. temperature, pH, biomolecules, CO2, light, electricity. These multi-responsive micro/nanogels their assemblies, capable recognizing...
Abstract L‐ascorbic acid (AA) is an essential nutrient that plays a vital role in our day‐to‐day body function, and maintaining health, for example, by serving as antioxidant. AA oxidation generates various products, some of which have not been identified. In this investigation, we show the room temperature reaction with copper sulfate (CuSO 4 ) product exhibits blue fluorescence. We studied how parameters impacted fluorescence emission intensity, varying reactant concentration, time, pH....