Abstract Apart from the anticancer, antioxidant, anti‐inflammatory effects, and inhibition of aromatase, chrysin is involved in protection cardiovascular disorders. Cardiovascular complications are main cause death induced by aluminum phosphide (AlP) which related to oxidative stress mitochondrial damages. For this purpose, we investigated effect as an antioxidant protective agent against AlP‐induced toxicity isolated cardiomyocytes mitochondria obtained rat heart ventricular. Using...

Alkylating agents such as N-Ethyl-N-Nitrosourea (ENU) are ubiquitous within living cells and in the environment. This study designed to evaluate chemopreventive activity of vanillic acid on ENU-induced toxicity carcinogenesis mice an animal model chronic lymphocytic leukemia (CLL). The female, Swiss albino were divided into three groups each with 7 mice, group I received normal saline, II, ENU at a dose 80 mg/kg body weight i.p. induce CLL 31th day study, III, pretreated 20 weight/day, up 30...

The purpose of this study is to examine thymoquinone (TQ), as a bioactive compound Nigella sativa, from safety point view and evaluate the possible toxic effects on isolated mitochondria screening tool for drug predictive toxicology. Mitochondria were form different organs (brain, heart, kidney liver) treated with various concentrations TQ (0–2000 µM). Mitochondrial toxicity parameters such succinate dehydrogenases (SDH) activity, mitochondrial swelling, lipid peroxidation, reactive oxygen...

Ellagic acid (EA) exerts, neuroprotective, mitoprotective, anti-oxidative and anti-inflammatory effects. We evaluated protective effect of EA on ethanol-induced fetal alcohol spectrum disorders (FASD).

Clozapine (CLZ) as an antipsychotic agent is very effective in treating of psychosis disorders and resistant schizophrenia, but the risk severe cardiac toxicity effects restricts its clinical use. There are several interrelated hypotheses to explain clozapine-induced cardiotoxicity which all them may be related oxidative stress. Therefore, current study investigated harmful clozapine on cardiomyocytes assessed cytoprotective effect ellagic acid (EA). Freshly isolated adult rat ventricular...

In spite of the cardiotoxic effect selective cyclooxygenase-2 inhibitors, they are most widely used as anti-inflammatory and analgesic drugs. Today, valdecoxib rofecoxib have been withdrawn in market but celecoxib remains. this study, we focused on an analysis toxic effects isolated mitochondria. Isolated rat heart mitochondria were obtained using differential centrifugation. Using flow cytometry biochemical assays, searched succinate dehydrogenases, mitochondrial membrane potential (MMP),...

Curcumin has a wide range of pharmacological activities, including antioxidant, anti-inflammatory and tissue protective. In here we hypothesized that curcumin-loaded chitosan-coated solid lipid nanoparticles (CuCsSLN) are able to increase its overall bioavailability hence antioxidant mitochondria;/lysosomal protective properties curcumin. CuCsSLN were prepared using solvent diffusion technique for formation (SLNs) electrostatic coating positive-charged chitosan negative surface SLNs. showed...

Abstract Clozapine (CLZ) is unusually efficient in psychotic diseases. Nonetheless, its use confined due to potentially life‐threatening adverse events, including cardiotoxicity. Since the cardiotoxicity of CLZ mediated through generation active metabolites, free radical, and inflammation. Here, we tested this hypothesis that kaempferol (KP) as antioxidant anti‐inflammatory agent could attenuate CLZ‐induced mitochondrial/lysosomal oxidative damages rat ventricular cardiomyocytes. Rat...

Abstract Background In spite of the cardiotoxic effect selective cyclooxygenase-2 inhibitors, they are most widely used as anti-inflammatory and analgesic drugs. Today, valdecoxib rofecoxib have been withdrawn on market but celecoxib remains. this study, we focused an analysis toxic effects isolated mitochondrial. Methods rat heart mitochondria were obtained using differential centrifugation. Using flowcytometry biochemical assays searched succinate dehydrogenases (SDH), mitochondrial...

Abstract The safety of diclofenac (DIC) use in clinical practice has been questioned because adverse cardiovascular effects. Previous studies have indicated that DIC cause mitochondrial dysfunction and oxidative stress heart mitochondria. aim this study was to investigate the protective effect calcitriol against toxicity potency rat For purpose, mitochondria were isolated with mechanical lysis differential centrifugation. Then pretreated 3 different concentrations (2.5, 5 10 µM) for min at...

Abstract Mitochondrial toxicity has been shown to contribute a variety of organ toxicities such as, brain, heart, kidney, and liver. Ifosfamide (IFO) as an anticancer drug, is associated with increased risk neurotoxicity, cardiotoxicity nephrotoxicity, hepatotoxicity, hemorrhagic cystitis. The aim this study was evaluate the direct effect IFO on isolated mitochondria obtained from rat Mitochondria were mechanical lysis differential centrifugation different organs treated various...

Prenatal alcohol exposure causes fetal developmental abnormalities via mitochondrial dysfunction, reactive oxygen species (ROS) formation, and oxidative stress. Therefore, we aimed to investigate the potential of hesperidin as a protective antioxidative agent in newborn male rats model for syndrome (FAS).

Doxorubicin (DOX) is an anticancer drug which used for treatment of several types cancers. But the clinical use doxorubicin limited because its cardiotoxicity and cardiomyopathy. Mitochondrial-dependent oxidative stress cardiac inflammation appear to be involved in doxorubicin-induced cardiotoxicity. Betanin as a bioactive compound Beetroot ( Beta vulgaris L.) displays anti-radical, antioxidant gene regulatory cardioprotective activities. In this current study, we investigated protective...

Abstract It has been reported that lipophilic statins such as atorvastatin can more readily penetrate into β‐cells and reach the mitochondria, resulting in mitochondrial dysfunction, oxidative stress, decrease insulin release. Many studies have shown natural products protect dysfunction induced by drug different tissue. We aimed to explore protection potency of hesperidin, vanillic acid, sinapic acid compounds against pancreas isolated mitochondria. Mitochondria were form rat directly...