A5101457521- Aluminum toxicity and tolerance in plants and animals
- Chemotherapy-induced organ toxicity mitigation
- Sport and Mega-Event Impacts
- Chemotherapy-induced cardiotoxicity and mitigation
- Alcohol Consumption and Health Effects
- Mitochondrial Function and Pathology
- Cancer-related cognitive impairment studies
- Computational Drug Discovery Methods
- Nigella sativa pharmacological applications
- Drug-Induced Hepatotoxicity and Protection
- Inflammatory mediators and NSAID effects
- Neuroscience and Neuropharmacology Research
- Essential Oils and Antimicrobial Activity
- Acute Lymphoblastic Leukemia research
- Electrochemical Analysis and Applications
- Plant chemical constituents analysis
- Botanical Research and Applications
- Genomics, phytochemicals, and oxidative stress
- Sesame and Sesamin Research
- Laser Applications in Dentistry and Medicine
- Insect Pest Control Strategies
- Fatty Acid Research and Health
- Curcumin's Biomedical Applications
- Cholinesterase and Neurodegenerative Diseases
- Chemical synthesis and alkaloids
Ardabil University of Medical Sciences
2021-2025
Kerman University of Medical Sciences
2024
Bam University of Medical Sciences
2020
Payame Noor University
2016
Oxidative stress and mitochondrial dysfunction are involved in the mechanisms of cardiac toxicity induced by aluminum phosphide (AlP). AlP-induced cardiotoxicity leads to cardiomyocyte death, cardiomyopathy, dysfunction, eventually severe heart failure death. Importantly, protecting cardiomyocytes from death resulting AlP is vital for improving survival. It has been reported that flavonoids such as myricetin (Myr) act modifiers function prevent damage many insults subsequent cell...
Abstract Background Methamphetamine is widely abused in all parts of the world. It has been reported that short-term and long-term methamphetamine exposure could damage dopaminergic system induce cardiomyopathy cardiotoxicity via mitochondrial dysfunction oxidative stress. Vanillic acid (VA), a phenolic compound derived from plants, known for its antioxidant protection properties. Methods In current study we used VA attenuating Methamphetamine-induced toxicity cardiac mitochondria. Isolated...
Ifosfamide (IFO) kidney damage is an important organ toxicity in children and adults undergoing chemotherapy. Previous evidence has shown that IFO toxic metabolites such as acrolein are associated with mitochondrial dysfunction, depletion of antioxidants, oxidative stress may predispose the to toxicity. Bioactive food compounds ellagic acid (EA) found fruits been described antioxidant protective agents against toxicity-related stress. In current study, effects EA on IFO-induced...
Lithium is commonly used in the treatment of bipolar disorders (BD) and consumer electronics. It has been reported that lithium exposure associated with mitochondrial dysfunction oxidative stress isolated cardiac mitochondria. Mitochondrial protection a key role myocardial tissue homeostasis, cardiomyocyte survival inhibition cardiotoxicity. Hesperidin as flavanone cardioprotective agent shown high potential antioxidant activity restoration different models. Therefore, we aimed to evaluate...
Abstract Mitochondrial dysfunction and oxidative stress are identified to contribute the mechanisms responsible for pathogenesis of Alzheimer's disease (AD). Scopolamine (SCO) as a potent drug inducing memory learning impairment is associated with mitochondrial stress. In AD clinical trials molecules antioxidant properties have shown modest benefit. Betanin multifunctional molecule powerful antioxidative may be effective in treatment neurodegenerative. Hence, this study was designed...
Ifosfamide (IFO) is a widely used antineoplastic drug with broad-spectrum efficacy against various types of cancer. However, different toxicities associated IFO has limited its use. This study was to establish the prophylactic effects betanin, chrysin and ellagic acid IFO-induced neurotoxicity in rats.Animals were randomly divided into eight groups, control, IFO, + chrysin, acid, groups. Betanin (50 mg/kg, i.p.), (25 i.p.) administered rats once daily for two consecutive days. (500 on third...
Ketamine is a cardiotoxic agent and can deplete ATP in cardiomyocytes through mitochondrial dysfunction. We investigated the effects of gallic acid sesame oil ketamine-induced cardiotoxicity rats. Male Wistar rats were randomly divided into six groups including control; ketamine; ketamine + acid; oil; oil. Serum cardiac marker, tissue oxidative stress markers, histopathological analysis toxicity parameters (succinate dehydrogenase activity, swelling, reactive oxygen species (ROS) production...
Mitochondria are the main target organelles through which drugs and chemicals exert their toxic effect on cardiomyocytes. The mitochondria-related mechanisms of celecoxib-induced cardiotoxicity have been extensively studied. Accumulated evidence shows natural molecules targeting mitochondria proven to be effective in preventing cardiotoxicity.In present study, we examined ameliorative gallic acid (GA) against cellular mitochondrial toxicity isolated cardiomyocytes mitochondria.The were...
Due to the possibility of manipulation inorganic nanomaterial, they can be interacting with both surface and inside biomolecules leading targeting diagnosis breast cancer. Therefore, usage smart nanomaterials-based on imaging techniques causes produce high resolution sensitivity excellent contrasts for cancer as well detection metastases in In here we investigate many types diagnostic approaches based tests along various nanomaterials development traditional methods.
Open, arid, unbuilt spaces by roadside, in neighborhoods and urban areas are of hidden that despite numerous potential, they left unused. Due to lack proper public sport places the cities, changing into open sports ground, these can be a good opportunity improve quality life, organization spaces, neighborhood orientation, development services welfare. Although transforming non-spaces dynamic has happened some cities based on article 110 Municipal Act, neglect social economic structure...