A5032990700- Vasculitis and related conditions
- Otitis Media and Relapsing Polychondritis
- Systemic Sclerosis and Related Diseases
- Systemic Lupus Erythematosus Research
- Ocular Diseases and Behçet’s Syndrome
- Renal Diseases and Glomerulopathies
- Urticaria and Related Conditions
- IgG4-Related and Inflammatory Diseases
- Sarcoidosis and Beryllium Toxicity Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Amyloidosis: Diagnosis, Treatment, Outcomes
University Hospital of Basel
2020-2024
Hospital Base
2023
Objectives To characterise factors associated with permanent vision loss (PVL) and potential reasons for the therapeutic delay contributing to PVL in giant cell arteritis (GCA). Methods Retrospective analysis of GCA patients diagnosed at University Hospital Basel between December 2006 May 2021. Results Of 282 (64% females), 49 (17.4%) experienced PVL. In 43/49 (87.8%) occurred before treatment. these, 24 (55.8%) had first non-ocular symptoms eventually sought consultation when a median 21...
Objectives We evaluated the feasibility of a rapid glucocorticoid tapering regimen to reduce exposure in patients with giant cell arteritis (GCA) treated glucocorticoids only. Methods Newly diagnosed GCA planned 26-week at University Hospital Basel were included. Data on relapses, cumulative steroid doses (CSD) and therapy-related adverse effects collected from patients’ records. Results Of 47 (64% women, median age 72 years), 32 (68%) had relapsed. Most relapses minor (28/32) 2/3 those...
To describe the feasibility and diagnostic accuracy of 18F-FDG positron emission tomography-computed tomography (PET/CT) temporal artery compared with ultrasound histology in patients suspicion having giant cell arteritis (GCA).Patients suspected GCA were included. PET/CT standard uptake value ratios compression sign on assessed for trunk, parietal frontal branches artery. Temporal biopsies systematically re-assessed, if available.In 17/34 patients, was confirmed. confirmed vasculitis 9/17...
We previously proposed standard uptake value (SUV) ratio-based cut-off values for [18F] fluorodeoxyglucose-positron emission tomography/computed tomography (PET/CT) diagnosing giant cell arteritis (GCA) with high diagnostic accuracy. Here we confirm our findings in an independent cohort and report a simplified procedure using SUV ratio to diagnose LV-GCA. Patients suspected GCA were consecutively included. The ‘peak ratio’ was defined two-step approach. First, the vessel visually brightest...
Abstract Objectives To investigate the hypothesis that a history of PMR is associated with more severe and damaging disease course in newly diagnosed GCA patients. Methods This was retrospective analysis patients between December 2006 May 2021. We compared vascular ultrasound findings (presence vasculitis stenosis) without prior PMR. Results Forty-nine 311 (15.8%) had median 30.6 (IQR 7.1–67.3) months before diagnosis. Patients often large vessel (LVV) (51.0% vs 25.0%, P < 0.001)...
<h3>Background</h3> Subclinical giant cell arteritis (GCA) can be found in imaging studies at diagnosis of polymyalgia rheumatica (PMR) up to 30% patients [1]. Newly diagnosed GCA with a preceding PMR may therefore present more advanced vasculitic vessel alterations than without prior PMR. <h3>Objectives</h3> To compare vascular ultrasound (US) findings newly and history <h3>Methods</h3> Retrospective analysis the University Hospital Basel between 12/2006 05/2021. <h3>Results</h3> 49 311...
Background: For the diagnosis of giant cell arteritis (GCA) several diagnostic tools do exist such as 18 F-FDG-PET/CT (PET) with excellent accuracy for larger vessels and ultrasound temporal arteries (TA). Recent data propose that PET is able to detect vasculitis in small TA (1). Comparison PET, (US) histology on a segment level has not been done. Objectives: To describe university clinic analyse strength limitations by comparing F-FDG uptake US results level. Methods: We analysed patients,...