A5102761154- Circadian rhythm and melatonin
- Salivary Gland Disorders and Functions
- Ocular Surface and Contact Lens
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Adipose Tissue and Metabolism
- Sleep and Wakefulness Research
- Peroxisome Proliferator-Activated Receptors
- Gut microbiota and health
- Retinal and Optic Conditions
- Olfactory and Sensory Function Studies
- Advanced Glycation End Products research
- Adipokines, Inflammation, and Metabolic Diseases
- Biochemical Analysis and Sensing Techniques
- Tryptophan and brain disorders
- melanin and skin pigmentation
- RNA modifications and cancer
- Glaucoma and retinal disorders
- Regulation of Appetite and Obesity
- Light effects on plants
- Chronic Disease Management Strategies
- Ophthalmology and Visual Health Research
- Chemical and Physical Studies
- Spaceflight effects on biology
- Genetics, Aging, and Longevity in Model Organisms
Henan Provincial Eye Hospital
2019-2025
Henan Provincial People's Hospital
2019-2025
Zhengzhou University
2018-2025
Henan University
2020-2025
Purpose: This study investigated the impact of hyperglycemia in type 2 diabetes mellitus (T2DM) on circadian rhythms and function lacrimal glands (LGs) contributing to dry eye syndrome. We assessed effects gene expression, immune cell recruitment, neural activity, metabolic pathways, evaluated effectiveness insulin restoring normal LG function. Methods: Using a T2DM mouse model (db/db mice), transcriptomic changes LGs were analyzed through RNA sequencing over 24-hour period. Rhythmic...
To explore the efficacy of artificial intelligence (AI)-based screening for diabetic retinopathy (DR) in type 2 diabetes mellitus (T2DM) patients.Data were obtained from 549 T2DM patients who visited Fundus Disease Center at Henan Provincial People's Hospital 2018/10-2020/09. DR identification and grading conducted by two retina specialists, EyeWisdom®DSS EyeWisdom®MCS, with ophthalmologist as reference standard, EyeWisdom was evaluated according to sensitivity, specificity, positive...
Purpose: Chronic jet lag (CJL) is known to disrupt circadian rhythms, which regulate various physiological processes, including ocular surface homeostasis. However, the specific effects of CJL on lacrimal gland function and underlying cellular mechanisms remain poorly understood. Methods: A model was established using C57BL/6J mice. Extraorbital glands (ELGs) were collected at 3-hour intervals for RNA extraction high-throughput sequencing. Circadian transcriptomic profiles analyzed,...
Abstract Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance and a relative deficiency of insulin. This study aims to screen T2DM-related maker genes in the mouse extraorbital lacrimal gland (ELG) LASSO regression.C57BLKS/J strain with leptin db/db homozygous mice (T2DM, n = 20) wild-type (WT, were used collect data. The ELGs collected for RNA sequencing. regression was conducted marker training set. Five selected from 689 differentially expressed regression, including...
Diabetic retinopathy (DR) is a common complication of type II diabetes mellitus (T2DM) and leading cause blindness in the working population. Apolipoprotein levels have been reported to be associated with risk DR. This study aimed develop predictive model for DR based on apolipoproteins (apoA apoB) menopausal status Chinese Han women T2DM evaluate model's effectiveness. Data from 2339 were collected between January 2018 June 2022. Multilevel regression was used explore independent effect...
Sleep loss markedly affects the structure and function of lacrimal gland may cause ocular surface disease as a common public health problem. This study aims to investigate circadian disturbance caused by sleep leading dysfunction extraorbital glands (ELGs).A mouse deprivation (SD) model for studies was built in C57BL/6J male mice. After four weeks, ELGs were collected at three-hour intervals during 24-hour period. The Jonckheere-Terpstra-Kendall algorithm used determine composition, phase,...
This study used high-throughput RNA sequencing (RNA-Seq) and bioinformatics analysis to investigate the altered transcriptome profile of aging lacrimal glands in mice that occurs over course a 24-hour cycle.Male C57BL/6J aged 12 weeks (young) 20 months (aging) were housed pathogen-free setting with 12-hour light/12-hour dark cycle. Throughout cycle, mouse extraorbital (ELGs) collected at eight time points three-hour intervals. To prepare for RNA-Seq, whole mRNA was extracted. Differentially...
The study aims to explore the distribution characteristics and influencing factors of diabetic retinopathy (DR) in diabetes mellitus (DM) patients association rules eye diseases these patients. Data were obtained from 1284 DM at Henan Provincial People's Hospital. Association employed calculate probability common occurrence eye-related A web visualization network diagram was used display DR prevalence people aged < 40 years (≥ 58.5%) higher than that those 50-60 (≤ 43.7%). Patients with...
Purpose: A high-fat diet (HFD) increases the risk of developing many systemic diseases; however, effects high fat intake on lacrimal gland functions and molecular mechanisms underlying these are unknown. We explored an HFD circadian rhythms extraorbital glands (ELGs). Methods: Male C57BL/6J mice maintained a 12/12-hour light/dark cycle were fed ad libitum or normal chow (NC) for 2 weeks. The ELGs collected from euthanized animals every 3 hours throughout (24 hours). Using high-throughput...
Abstract This study aims to explore the relationship between abnormal renal- and liver-function diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM). A total of 994 T2DM who received inpatient treatment Endocrinology Department Henan Province People’s Hospital were included study. Logistic regression was performed identify renal liver function DR. Receiver operator characteristic analysis efficacy risk factors predicting Higher urine albumin [ OR (95% CI ) =...