A5100389594- Esophageal Cancer Research and Treatment
- Head and Neck Cancer Studies
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Radiation Therapy and Dosimetry
- Colorectal and Anal Carcinomas
- Endometrial and Cervical Cancer Treatments
- Lymphatic System and Diseases
- Diagnosis and Treatment of Venous Diseases
- Effects of Radiation Exposure
- RNA modifications and cancer
- Inflammatory Biomarkers in Disease Prognosis
- Oral health in cancer treatment
- Fatty Acid Research and Health
- Lung Cancer Treatments and Mutations
- Tribology and Lubrication Engineering
- Liver Disease and Transplantation
- Ovarian cancer diagnosis and treatment
- Cancer-related molecular mechanisms research
- Head and Neck Surgical Oncology
Chang Gung University
2016-2025
Kaohsiung Chang Gung Memorial Hospital
2016-2025
Chung Shan Medical University Hospital
2017-2024
Academy of Medical Sciences
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Nanjing Medical University
2011-2024
Jiangsu Province Hospital
2024
Ocean University of China
2011-2024
Liaocheng University
2024
National Sun Yat-sen University
2024
ABSTRACT We hypothesized that hepatitis C virus (HCV) persistence is related to the sequence variability of putative envelope genes. This hypothesis was tested by characterizing quasispecies in specimens collected every six months from a cohort acutely HCV-infected subjects (mean duration specimen collection, 72 after seroconversion). evaluated 5 individuals who spontaneously cleared viremia and 10 with persistent cloning 33 1-kb amplicons spanned E1 5′ half E2, including hypervariable...
The aim of the study is to investigate alteration plasma miRNA in head and neck squamous cell carcinoma (HNSCC). Altered microRNAs (miRNAs) expression has been found many cancers, including lung cancer, breast prostate bladder cancer colorectal cancer. Many recent studies have demonstrated that aberrant miRNAs were also various types cancers. However HNSCC remains unclear. In this present study, profiles ten miRNAs, let-7a, miR-21, miR26b, miR-34c, miR-99a, miR-133a, miR-137, miR-184,...
Background. Ferroptosis is a nonapoptotic form of programmed cell death, which may be related to the occurrence and development sepsis-induced acute respiratory distress syndrome (ARDS)/acute lung injury (ALI). Mucin 1 (MUC1) kind macromolecule transmembrane glycoprotein. Previous studies have shown that MUC1 could relieve ALI in sepsis predict whether patients would develop into ARDS. However, role ferroptosis ALI/ARDS remains unclear. Materials Methods. Sera samples from 50 with...
Ulcerative colitis (UC) represents an inflammatory disease characterized by fluctuations in severity, posing substantial challenges treatment. The gut microbiota plays a pivotal role the pathogenesis of UC. This study sought to identify drugs specifically targeting mitigate We initiated meta-analysis on UC patients UC-associated bacterial strains. Subsequently, we screened 164 dietary herbal medicines vitro potential prebiotics for bacterium, Bacteroides thetaiotaomicron. DSS-induced mouse...
Abstract Hepatocellular carcinoma (HCC) is a highly heterogeneous and malignant cancer with poor overall survival. The application of sorafenib major breakthrough in the treatment HCC. In our study, FOXQ1 was significantly overexpressed sorafenib-resistant HCC cells suppressed sorafenib-induced ferroptosis. We found that phosphorylation at serine 248 critical for suppression Furthermore, as upstream kinase FOXQ1, JNK1, which activated by sorafenib, can directly phosphorylate site FOXQ1....
Background: Inferior lymphatic vessel (LV) quality was thought to be associated with prolonged lymphedema duration (LD), which can lead unfavorable lymphaticovenous anastomosis (LVA) outcomes. However, increasing evidence supports the use of LVA in treatment advanced lymphedema. Hence, this study aimed determine impact LD on LV and outcomes after patients secondary lower limb Patients Methods: A total 189 who underwent supermicrosurgical were retrospectively reviewed enrolled. The group...
Two mosquito STATs, AaSTAT and CtSTAT, have been cloned from Aedes albopictus Culex tritaeniorhynchus mosquitoes, respectively. These two STATs are more similar to those of Drosophila, Anopheles, mammalian STAT5 in the DNA binding Src homology 2 domains. The mRNA transcripts expressed at all developmental stages, proteins present predominantly pupal adult stages both mosquitoes. Stimulation with lipopolysaccharide resulted an increase tyrosine phosphorylation activity CtSTAT as well...
Accurate T-staging is pivotal for predicting prognosis and selecting appropriate therapies esophageal squamous cell carcinoma (ESCC). The diagnostic performance of fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) its uncertain. We investigated use FDG PET/CT preoperative patients with ESCC. Patients ESCC given scans, either (CRT[+] group) or without (CRT[−] neoadjuvant chemoradiotherapy, were retrospectively reviewed. Maximal standardized uptake value...
BackgroundHypoxia suppresses global protein production, yet certain essential proteins are translated through alternative pathways to survive under hypoxic stress. Translation via the internal ribosome entry site (IRES) is a means produce stress conditions such as hypoxia; however, underlying mechanism remains largely uncharacterized.MethodsProteomic and bioinformatic analyses were employed identify hnRNPM an IRES interacting factor. Clinical specimens mouse model of tumorigenesis used for...
Abstract Background Proton radiotherapy has a dosimetric advantage over photon radiotherapy. Many retrospective studies have shown promising results with proton in treating hepatocellular carcinoma (HCC). However, clinical evidence demonstrating the benefit of protons photons is still limited. We therefore compared outcomes two modalities using medical research databases from our foundation. Methods conducted propensity score-matched cohort study based on multi-institution organization...
ABSTRACT The putative envelope 2 (E2) gene of hepatitis C virus (HCV) contains a highly variable region referred to as hypervariable 1 (HVR1). We hypothesized that this genetic variability is driven by immune selection pressure, rather than representing the accumulation random mutations in with relatively little functional constraint. To test hypothesis, we examined E2 sequence human inoculum was passaged through eight chimpanzees, which appear have replicative rate (opportunity for chance...
Impaired heart rate variability (HRV) has been demonstrated as a negative survival prognosticator in various diseases. We conducted this prospective study to evaluate how HRV affects brain metastasis (BM) patients. Fifty-one BM patients who had not undergone previous operation or radiotherapy (RT) were recruited from January 2010 July 2012, and 40 included the final analysis. A 5-minute electrocardiogram was obtained before whole radiotherapy. Time domain indices of compared with other...
The changing pattern of hepatitis C virus (HCV) infection could have a significant impact on future medical prevention practices and therapies.The purpose this study was to describe the HCV in southwest China using clinical epidemiology, assess association between genotypes distribution certain potential risk factors.A retrospective analysis which included 1208 subjects with chronic registered at Southwest Hospital (Chongqing, China) performed. information reviewed data collected from...
Background: Foreign body (FB) ingestion in the gastrointestinal tract is a common and urgent problem observed children adults. However, there may be difficulty locating FBs complications associated with their removal. This study aimed to identify risk factors correlated presence removal of FBs.
To scrutinize the pretreatment prognosticators on survival and late toxicities in a homogenous cohort of nasopharyngeal carcinoma (NPC) patients treated by simultaneous integrated boost intensity-modulated radiation therapy (SIB-IMRT).A total 219 non-distant metastatic NPC consecutively SIB-IMRT at single institute were collected. The factors including socio-demographic variables, TNM stages, gross tumor volume (GTV), Epstein-Barr virus (EBV)-DNA, hematologic inflammatory markers analyzed....