Lead is a common heavy metal used in variety of products. We investigated the effect lead-oxide nanoparticles (PbO-NPs) on histological structure rat olfactory bulb (OB) and potential therapeutic stem cell-derived exosomes (EXOs). Forty male rats were included: 8 for EXO isolation 32 distributed into 4 groups: control, PbO-NPs group [intranasal (IN) 50 µL PbO-NPs/rat 3 weeks], recovery (PbO-NPs weeks left another weeks), PbO-NP-EXO then IN weeks). After 7 weeks, behavioral tests done before...

Hepatitis C virus (HCV) is a major cause of chronic hepatitis and hepatic fibrosis. Liver biopsy, because its limitations risks, might be considered an imperfect gold standard for assessing the severity liver diseases. In this study, we aimed to prospectively validate FibroTest (FT) ActiTest (AT) as noninvasive serum biochemical markers assessment degree fibrosis necroinflammatory activity respectively, in pediatric patients with HCV infection compare them biopsy.Fifty patients, aged 2 18...

Parkinson's disease (PD) is a progressive neurodegenerative disorder with behavioral and motor abnormalities. Androst-5-ene-3β, 17β-diol (ADIOL), an estrogen receptor (ER) β agonist, was found to mediate transrepressive mechanism that selectively modulates the extent of neuroinflammation and, in turn, neurodegeneration. In consensus, ERβ polymorphism more frequently detected early-onset PD patients. Thus, approach elucidate role agonists on PD, our study designed investigate possible...

Introduction: Acute kidney injury (AKI) is a syndrome of rapidly declining renal function. Cisplatin nephrotoxicity major cause AKI in about one third patients under cisplatin treatment. Stem cell therapy have been suggested as protective measure against cisplatin-induced AKI. The conditioned medium the stem cells (serum-free culture medium) has also found to minimize and might develop new therapeutic strategy that avoids administration.Aim Study: This study was conducted compare effect...

Introduction and aim of work The corneal epithelium acts as a transparent barrier, being the first line defense against physical, chemical, biological insults. Corneal wounds result alkali exposure cause reduced transparency cornea disability in form permanent visual impairment or even blindness. Moreover, they do not heal properly spontaneously there is lack satisfactory therapy. Thus, therapeutic efficacy topical application hyaluronic acid was investigated on burn model albino rats....

Introduction Chronic stress has been linked to many diseases. It proven increase the susceptibility of different rat organs, such as small intestine, colon, and brain, inflammatory also documented cause hypogonadism in humans laboratory animals. However, its effect on pancreas, especially exocrine part, received relatively little attention. Aim work The aim this study was assess chronic induced by immobilization structure both endocrine parts pancreas. In addition, present aimed evaluate...

Introduction Osteoarthritis (OA) is the most common chronic joint disease in elderly population, causing significant pain and disability. Currently available pharmacological therapies target palliation of pain. Hyaluronic acid (HA) major hydrodynamic component synovial fluid. Hence, intra-articular treatment with HAs has recently become widely accepted therapy for OA. Aim work The goal this study was to clarify whether potential efficacy intra- articularly injected HA early OA induced knee...

Abstract Introduction Aging process is a driving force behind the age associated diseases. The gastrointestinal tract (GIT), including colon, affected by aging process. Constipation, fecal incontinence, and impaction are common complaints of geriatric patients, probably reflecting colonic dysmotility. Interstitial cells Cajal might be involved in this process, however, there little known about changes these with aging. Aim objective work was to study effect on structure colon male albino...

Introduction: Aging is the impelling cause behind age related diseases. The colon, as a part of gastrointestinal tract, impacted by aging. Elders frequently complain constipation, fecal incontinency and impaction, that affects their life causes morbidity.Aim: To examine aging impact on histological structure colon wall in male albino rats. Materials methods: A total thirty rats were equally split into three groups: young, adult senile, aged six weeks, 16 weeks two years respectively. Colon...

Introduction: Silica oxide nanoparticles (SiO 2 NPs) have a dominant medical role because of their fundamental characteristics.They wide range size (from 5 to 1000 nm).They possess unique optical properties, high specific surface area, low density, adsorption capacity, capacity for encapsulation, and biocompatibility.These features led use in biomedical applications as catalyst supports, drug carriers, gene delivery.However, little is known about possible cytotoxic effects, especially with...

The electrocardiogram (ECG) is the primary diagnostic tool in cardiovascular diseases. Hence its interpretation a core competency medicine, where obvious deficiencies have been reported among learners. aim of this study was to introduce fundamentals ECG knowledge and through early clinical exposure (ECE) based on six-step approach for preclinical students ( n = 110) influence their skills thereafter. first step employed blended learning format using didactic lectures normal pathological...

Introduction Spontaneous proper healing of articular cartilage trauma in adults is rare and osteoarthritis might develop as a result. Cultured bone marrow mesenchymal stem cells (BM-MSCs) could differentiate into chondrocytes, thus be good choice for treating such trauma. Aim the work To assess efficacy an intraarticular injection BM-MSCs derived from young albino rats repair induced chondral defect knee joints adult rats. Materials methods Six male were used source BM-MSCs. In addition, 30...

Background: Responses to stress could range from homeostatic variations lifethreatening effects.Gender is accompanied by in oxidative that are implicated the development of metabolic diseases.Females were found be less susceptible stress.Aim: clarify differences responses chronic immobilization both rat sexes, and elucidate possible underlying mechanism(s).Methods: 40 adult albino rats sexes divided into 2 main groups: control stressed groups, each was subdivided male female groups.Stressed...

Introduction Hormonal replacement has been implicated as a possible therapeutic agent for ameliorating age-related cognitive decline in postmenopausal women. Estrogen particular enhanced learning and memory many women by improving the function of hippocampus after menopause. However, there is lack studies concerning most effective way therapy. Aim The aim study was to investigate effect hormonal on structure dentate gyrus assess therapy regimen. Materials methods Thirty six adult female...

Acute liver failure (ALF), like sepsis, is associated with an overwhelming activation of the immune response in which hepatic and circulating inflammatory cytokines play a pivotal role. Cholinesterase inhibition has been shown to have anti-inflammatory properties experimental sepsis. We investigated role neostigmine attenuating d-galactosamine (d-GalN)-induced ALF. Thirty-six female wistar rats were randomly allocated three groups: control group, d-GalN group receiving single i.p. injection...

Introduction: Age-related olfactory decline is increasingly recognized to be a major health problem with no known treatment yet, reflecting on individual safety, nutrition, physical and mental well-being.Intranasal administration of adipose derived stem cells (ADSCs) could an ideal curative strategy, bypassing the blood brain barrier risk for systemic exposure.Aim: To evaluate age related structural changes in bulb (OB) rats assess possible therapeutic role intranasally-administered ADSCs...

Introduction:Congenital heart defects are the most common of all congenital malformations and there is a higher incidence urinary tract anomalies in these cases Aim study: Our study aims to identify prevalence phenotypes kidney (CAKUT) among with diseases admitted cardiac ICU.Methods: Eighty seven neonates infants were ICU.Patients assessed for CAKUT mainly via pelvi-abdominal US screening exclude gross anomalies, along clinical, laboratory other imaging findings during PICU...