A5053884863- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Catalytic Cross-Coupling Reactions
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Metal complexes synthesis and properties
- Catalytic Alkyne Reactions
- Organometallic Complex Synthesis and Catalysis
- Synthetic Organic Chemistry Methods
- Catalytic C–H Functionalization Methods
- Asymmetric Hydrogenation and Catalysis
- Crystallography and molecular interactions
- Ferrocene Chemistry and Applications
- Click Chemistry and Applications
- Advanced biosensing and bioanalysis techniques
- Magnetism in coordination complexes
- Synthesis and Biological Evaluation
- Synthesis and Catalytic Reactions
- Sulfur-Based Synthesis Techniques
- Organic Light-Emitting Diodes Research
- Chemical Reactions and Isotopes
- Oxidative Organic Chemistry Reactions
- Molecular Junctions and Nanostructures
- Phenothiazines and Benzothiazines Synthesis and Activities
- Nanomaterials for catalytic reactions
- Electrochemical Analysis and Applications
University of Padua
2022-2025
Ghent University
2020-2022
Ca' Foscari University of Venice
2015-2022
Centro di Riferimento Oncologico
2021-2022
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2022
Ghent University Hospital
2020-2021
Moffitt Cancer Center
2021
Wayne State University
2020
Solução Ambiental Assessoria e Consultoria
2020
E Ink (South Korea)
2020
The first palladium organometallic compounds bearing N-trifluoromethyl N-heterocyclic carbenes have been synthesized. These η3 -allyl complexes are potent antiproliferative agents against different cancer lines (for the most part, IC50 values fall in range 0.02-0.5 μm). By choosing 1,3,5-triaza-7-phosphaadamantane (PTA) as co-ligand, we can improve selectivity toward tumor cells, whereas introduction of 2-methyl substituents generally reduces antitumor activity slightly. A series biochemical...
Abstract The development of novel and operationally simple synthetic routes to carbene‐metal‐amido (CMA) complexes copper, silver gold relevant for photonic applications are reported. A mild base sustainable solvents allow all reactions be conducted in air at room temperature, leading high yields the targeted compounds even on multigram scales. effect various bases N−H metallation was studied silico experimentally, while a mechanochemical, solvent‐free approach also developed. Our...
N-heterocyclic carbene (NHC) ligands have evolved from being simple lab curiosities to tertiary phosphine mimics finally take center stage as unique supporting in organometallic chemistry, homogeneous catalysis, and more recently medicinal chemistry materials science applications. Some of these aspects are presented here a perspective researchers that been fascinated by the area for quite some time.
The introduction of biologically relevant organic moieties in the coordination sphere transition metal complexes has recently become a well-established strategy to increase selectivity and biocompatibility metallodrugs. In this review, major advances achieved area research last three years are described detail. Particular attention is given bearing main biomolecules life: carbohydrates, lipids, nucleotides, proteins vitamins. Each paragraph summarizes synthetic employed obtain interest as...
This review article explores the innovative field of eco-friendly cyclodextrin-based coordination polymers and metal-organic frameworks (MOFs) for transdermal drug delivery in case skin cancer therapy. We critically examine significant advancements developing these nanocarriers, with a focus on their unique properties such as biocompatibility, targeted release, enhanced permeability. These attributes are instrumental addressing limitations inherent traditional treatments represent paradigm...
A series of new palladium allyl complexes bearing purine-based carbenes derived from caffeine, theophylline and theobromine have been prepared characterized by NMR spectroscopy, elemental analysis in two cases single crystal X-ray diffraction. The cytotoxic proapoptotic activities compounds determined vitro on human ovarian cancer A2780 SKOV-3 cell lines. These experiments shown that the palladium-allyl fragment induces a general cytotoxicity, but choice supporting ligands is paramount...
The considerable importance of α-arylated carbonyl compounds, which are widely used in the pharmaceutical industry, has prompted efficient synthetic strategies for their preparation.
A series of novel dinuclear NHC–gold–thiolato and –alkynyl complexes bearing aromatic linkers were successfully synthesized by an efficient simple synthetic route.
Palladium complexes are emerging as potential antitumor compounds. Recent experimental evidence suggests that the mechanism of action some organopalladium derivatives might involve target proteins such Thioredoxin Reductase (TrxR). In this work, we investigate different possible chemical mechanisms interaction between selected palladium(II)-η3-allyl and thiolates or selenolates, which key functional groups present in catalytic pocket TrxR. Our investigation, focusing on both anionic cationic...
The synthesis of a new dinuclear Pd(<sc>i</sc>) complex bearing two bis(NHC) ligands is discussed. This compound exhibited excellent bioactivity against several cancer cell lines and low toxicity toward normal cells. Its mode action also
Abstract The use of weak bases and mild conditions is currently the most sustainable attractive synthetic approach for preparation late‐transition metal complexes, some which are widely used in catalysis, medicinal chemistry materials science. Herein, cuprate, aurate or palladate species a continuous flow Cu I , Au Pd II ‐NHC complexes reported. All reactions examined proceed under extremely make technical grade acetone as solvent. scalability process was exemplified multigram‐scale...
Abstract The mechanochemical syntheses of allyl and indenyl palladate complexes are reported. All compounds were obtained in quantitative yields microanalytically pure without the need any workup. These stable chlorinated polar (DMSO or DMSO/H 2 O solutions) solvents. In solvents, they appear as ionic pairs which crystals suitable for single X‐ray diffraction studies have been obtained. Bonding solvation properties rationalized through scalar relativistic DFT calculations. Moreover, most...
A complete protocol for the synthesis of new palladacyclopentadienyl complexes with purine‐based carbenes as supporting ligands is described. The organometallic compounds were exhaustively characterized using NMR and infrared spectroscopies elemental analysis. single‐crystal X‐ray structure complex 2b coordinating also a triphenylphosphine was resolved. Some these showed an antiproliferative activity comparable to or better than that cisplatin on two human ovarian cancer lines: A2780...
Novel allyl palladium compounds stabilized by carbohydrate‐based N ‐heterocyclic carbenes (NHCs) were prepared and characterized nuclear magnetic resonance, high‐resolution mass spectrometry elemental analysis. The antiproliferative activity of the was tested on a panel different tumor lines, especially ovarian cancer MRC‐5 human lung fibroblasts (nontumor cells). These experiments showed that both mixed NHC/PPh 3 NHC/PTA (PTA = 1,3,5‐triaza‐7‐phosphaadamantane) complexes have IC 50 (half...
Sodium acetate enables the synthesis of [Au(NHC)Cl] complexes, as well their Au-alkynyl and -thiolato derivatives in high yields, under air technical grade, green solvents. The mild synthetic methods are also investigated computationally.
High-Grade Serous Ovarian Cancer (HGSOC) is the most common and lethal subtype of ovarian cancer, known for its high aggressiveness extensive genomic alterations.
Immunogenic cell death (ICD) is a regulated form of that activates an immune response through the release danger-associated molecular patterns (DAMPs), including calreticulin, ATP, and HMGB1. Gold complexes are known to induce ICD, but ICD-inducing potential palladium remains largely unexplored. We report first examples compounds capable inducing specifically allyl palladates bearing bis(imino)acenaphthene-NHC (BIAN-NHC) ligands. Cytotoxicity tests on human cancer lines revealed outperform...