A5040282546- Milk Quality and Mastitis in Dairy Cows
- Animal Genetics and Reproduction
- Studies on Chitinases and Chitosanases
- Antimicrobial Peptides and Activities
- Infant Nutrition and Health
- Identification and Quantification in Food
- Computational Drug Discovery Methods
- Bee Products Chemical Analysis
- S100 Proteins and Annexins
- Effects of Environmental Stressors on Livestock
- Liver Disease Diagnosis and Treatment
- Molecular Biology Techniques and Applications
- Protein Hydrolysis and Bioactive Peptides
- Synthesis and biological activity
- Microbial Inactivation Methods
- Pharmacology and Obesity Treatment
- Lipid metabolism and biosynthesis
- Machine Learning in Bioinformatics
- Plant biochemistry and biosynthesis
- Bone and Dental Protein Studies
- Click Chemistry and Applications
- Cancer therapeutics and mechanisms
- Natural Antidiabetic Agents Studies
- Meat and Animal Product Quality
- Natural Products and Biological Research
National Dairy Research Institute
2015-2024
Indian Council of Agricultural Research
2024
Indo Soviet Friendship College of Pharmacy
2020-2024
Post Graduate Institute of Medical Education and Research
2023
A series of new 2,5-disubstituted arylidene derivatives thiazolidinedione (16a-e, 17a-d, 18a-c) designed using molecular hybridization approach were synthesized, structurally characterized, and explored for their anti-obesity potential via inhibition Pancreatic Lipase (PL). Compound 18a presented the most potent PL inhibitory activity with IC50 = 2.71 ± 0.31 µM, as compared to standard drug, Orlistat (IC50 0.99 µM). Kinetic study revealed reversible competitive mode enzyme by compound an...
Abstract The mature mammary gland is made up of a network ducts that terminates in alveoli. innermost layer alveoli surrounded by the differentiated epithelial cells (MECs), which are responsible for milk synthesis and secretion during lactation. However, MECs state active proliferation pregnancy, when they give rise to like structures gland. Buffalo ( Bubalus bubalis ) constitute major source human consumption, precursor mainly their lactation potential. proteome defines functional suggests...
The lactating mammary gland harbours numerous matured alveoli with their lumen surrounded by differentiated epithelial cells (MECs), which are exclusively involved in milk synthesis and secretion. Buffalo (Bubalus bubalis) is the second major milk-producing animal, its physiology different from cattle. complete protein machinery MECs differentiation still not defined ruminants, particular, buffalo. Therefore, we have studied differential expression of regulated proteins vitro grown buffalo...
Background: The mammary gland is a crucial organ in dairy animals, responsible for milk production, regulated by intricate hormonal and cellular interactions. Traditional two-dimensional (2D) cell culture systems used research fail to replicate the complex vivo environment, limiting understanding of biology. study explores advantages three-dimensional (3D) Buffalo Mammary Epithelial Cells (BuMECs), aiming enhance morphological functional differentiation compared 2D cultures. Methods: BuMECs...
<title>Abstract</title> Background This study aimed to identify interacting protein partners for Mammary Gland Protein-40 (MGP-40), also known as CHI3L1. MGP-40 is a chitinase-like that plays significant roles in inflammation, cell proliferation, and tissue remodeling. It highly expressed during the involution phase of mammary gland has been implicated various biological processes, including epithelial-mesenchymal transition (EMT) immune infiltration. Understanding molecular mechanisms...
Background: Tirzepatide (LY3298176) was approved by U.S. Food and Drug Administration (FDA) on May 13th, 2022. The drug developed Eli Lilly Co. marketed under the trade name of ‘Mounjaro’, a first-in-class ‘Twincretin’, which is dual activator GIP GLP-1 receptors, resulting in improved blood sugar control type 2 diabetics review covered comprehensive insight discovery journey tirzepatide. Methods: Using keywords "Tirzepatide", "Twincretin", "Type Diabetes", "GLP-1", "GIP," data were gathered...