A5032559680- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Alcohol Consumption and Health Effects
- Metabolomics and Mass Spectrometry Studies
- Hepatitis B Virus Studies
- Diet, Metabolism, and Disease
- Hepatitis C virus research
- Drug-Induced Hepatotoxicity and Protection
- Gut microbiota and health
- Diet and metabolism studies
- Organ Transplantation Techniques and Outcomes
- Liver physiology and pathology
- Metabolism and Genetic Disorders
- Endoplasmic Reticulum Stress and Disease
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Clinical Nutrition and Gastroenterology
- Drug Transport and Resistance Mechanisms
- Research on Leishmaniasis Studies
- Acute Myeloid Leukemia Research
- Tuberculosis Research and Epidemiology
- Trypanosoma species research and implications
- Neonatal Health and Biochemistry
- Inflammation biomarkers and pathways
- Pancreatitis Pathology and Treatment
- Pregnancy and preeclampsia studies
Institute of Liver and Biliary Sciences
2016-2025
Cellular Research (United States)
2024
Asian Institute of Gastroenterology
2022
Saitama Medical University
2011
Klinički Bolnički Centar Split
1990
Albumin is a potent scavenger of reactive oxygen species (ROS). However, modifications in albumin structure may reduce its antioxidant properties and modulate immune‐regulatory functions. We examined alterations circulating severe alcoholic hepatitis (SAH) patients their contribution to neutrophil activation, intracellular stress, alteration associated molecular pathways. plasma oxidative stress were assessed SAH (n = 90), cirrhosis 60), healthy controls 30) using liquid chromatography/mass...
Acute‐on‐chronic liver failure (ACLF) is an ailment with high incidence of multiorgan (MOF) and consequent mortality. Dysregulated iron homeostasis macrophage dysfunction are linked to increased MOF. We investigated whether a panel circulating iron‐regulating proteins associated development MOF can predict 15‐ or 30‐day mortality in ACLF patients. One hundred twenty patients ACLF, 20 compensated cirrhosis, healthy controls were studied. Relative protein expression profiling was performed the...
Stimulation of naïve T cells during primary infection or vaccination drives the differentiation and expansion effector memory that mediate immediate long-term protection. Despite self-reliant rescue from infection, BCG vaccination, treatment, is rarely established against Mycobacterium tuberculosis ( M . tb ) resulting in recurrent (TB). Here, we show berberine (BBR) enhances innate defense mechanisms stimulates Th1/Th17 specific (T EM ), central CM tissue-resident RM responses leading to...
Rapid diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection still remains a major challenge. A multi-omic approach was adopted to analyze the specimens 20 SARS-CoV-2-positive, negative and 15 H1N1 pdm 2009 positive cases. Increased basal level MX1 (MX dynamin-like GTPase 1) WARS (tryptophan-tRNA ligase) correlated with SARS-CoV-2 its outcome. These markers were further validated in 200 suspects. MX1>30pg/ml WARS>25ng/ml segregated virus positives [AUC = 94% CI:...
Abstract Background and Aims Histopathological examination is the gold standard for detection of gallstone (GS) or gallbladder carcinoma (CAGB). Bile concentrated in (GB) expected to recapitulate metagenomics molecular changes associated with development CAGB. Approach Results samples were screened lipidomics metaproteome (metagenomics) signatures capable early cancer GB anomalies. Analysis training cohort ( n = 87) showed that metastability bile was reduced CAGB p < 0.05). significant...
Background: Hepatitis-E virus (HEV)-induced liver failure during pregnancy leads to maternal and fetal complications. This study investigates the HEV-associated metabolomic immunological changes elucidate worsening of obstetric outcomes in patients with acute (ALF) due HEV. Methods: Pregnant women (i) viral hepatitis, IgM HEV positive (AVH-E, n = 31, Gr.I), (ii) (ALF-E, 15, Gr.II), (iii) hepatitis but negative for infections (non-HEV, 30, Gr.III), healthy (HC, 21, Gr.IV) were evaluated at...
Severe alcoholic hepatitis (SAH) is associated with iron accumulation in hepatocytes/macrophages. This possibly correlates inflammation and stress but the exact mechanism still remains obscure. To understand role of mechanisms systemic iron-overload, a transcriptomic study liver Peripheral Blood -Mononuclear-Cells (PBMCs) was undertaken SAH patients, without hepatic iron-overload. Our results show that iron-overload hepatocytes/macrophages due to an increased expression iron-loading...
Decompensated cirrhosis (DC) is susceptible to infections and sepsis. Neutrophils monocytes provide the first line of defense encounter infection. We aimed evaluate proteins related neutrophils functionality in 70 (DC), 40 with sepsis, 30 without (w/o) sepsis 15 healthy controls (HC) plasma was analyzed for proteomic analysis, cytokine bead array, endotoxin, cell free DNA whole blood cells were nCD64-mHLADR index, neutrophils-monocytes, QRT-PCR. index significantly increased (p < 0.0001)...
Bacille Calmette-Guerin (BCG) generates limited long-lasting adaptive memory responses leading to short-lived protection against adult pulmonary tuberculosis (TB). Here, we show that host sirtuin 2 (SIRT2) inhibition by AGK2 significantly enhances the BCG vaccine efficacy during primary infection and TB recurrence through enhanced stem cell (TSCM) responses. SIRT2 modulated proteome landscape of CD4+ T cells affecting pathways involved in cellular metabolism T-cell differentiation....
Bacterial vaginosis (BV) is a common clinical manifestation of perturbed vaginal ecology associated with adverse sexual and reproductive health outcomes if left untreated. The existing diagnostic modalities are either cumbersome or require skilled expertise, warranting alternate tests. Application machine-learning tools to heterogeneous high-dimensional multi-omics datasets finds promising potential in data integration may aid biomarker discovery.
Abstract Background and Aims Acute‐on‐chronic liver failure (ACLF) is a serious illness associated with altered metabolome, organ high mortality. Need for therapies to improve the metabolic milieu support regeneration are urgently needed. Methods We investigated ability of haemoperfusion adsorption (HA) therapeutic plasma exchange (TPE) in improving profile survival ACLF patients. Altogether, 45 patients were randomized into three groups: standard medical therapy (SMT), HA TPE groups. Plasma...
Summary Background Severe alcoholic hepatitis patients have high mortality and limited response to corticosteroids. Microvesicles reflect cellular stress disease conditions. Aims To investigate whether microvesicles are associated with severity, steroid therapy inflammation in severe hepatitis. Methods originating from different cells were studied pre‐therapy 101 patients; (71 responder corticosteroid 30 nonresponders) 20 healthy controls. determined peripheral hepatic vein samples using...
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The fate of Mycobacterium tuberculosis infection is governed by immune signaling pathways that can either eliminate the pathogen or result in (TB). Anti-TB therapy (ATT) extensive and efficacious only against active, drug-sensitive strains M. tuberculosis. Due to severe side effects, ATT often causes impairment host immunity, making it imperative use novel immunotherapeutics for better clinical outcomes. In this study, we have explored immunomodulatory potential withaferin A (WA) as an...
Patients with severe alcoholic hepatitis (SAH) not responding to glucocorticoid therapy have higher mortality, though they do differ in their baseline clinical characteristics and prognostic scores from those who respond therapy. We hypothesized that the hepatic gene expression differs between responders (R) non-responders (NR). Baseline liver transcriptome was compared R NR Indian (16 each) French (5 NR, 3 R) patients SAH. There were differentially expressed genes (DEGs) R, (1106...
Vertical transmission of hepatitis B virus (HBV) from the mother to newborn often results in viral persistence. To understand mechanisms maternofetal HBV transmission, we studied maternal immunity and peripheral blood mononuclear cell (PBMC) transcriptome mothers newborns. We included 50 babies who were surface antigen (HBsAg) positive: 22 transmitting (group [Gr.] I) 28 nontransmitting (Gr. II) newborns 10 healthy mother–baby pairs III). PBMCs analyzed for HBV‐specific dendritic cells...
Hyperoxidized albumin promotes inflammation and modulates several immune cells in severe alcoholic hepatitis (SAH). Platelets mediate by interacting with cells, endothelium, other cells. The role of hyperoxidized platelet activation alteration phenotype/functions is not known. Quantitative proteomics performed 10 patients SAH was compared cirrhosis healthy controls, respectively. Dysregulated pathways were identified validated a separate cohort (n = 40). Healthy platelets exposed to patient...