A5062686223- Alcohol Consumption and Health Effects
- Forensic Toxicology and Drug Analysis
- Substance Abuse Treatment and Outcomes
- Cannabis and Cannabinoid Research
- Neurotransmitter Receptor Influence on Behavior
- Liver Disease Diagnosis and Treatment
- Poisoning and overdose treatments
- Pharmacogenetics and Drug Metabolism
- Opioid Use Disorder Treatment
- Pain Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Eicosanoids and Hypertension Pharmacology
- Smoking Behavior and Cessation
- Muscle metabolism and nutrition
- Traffic and Road Safety
- Alcoholism and Thiamine Deficiency
- Diet and metabolism studies
- Epilepsy research and treatment
- Drug-Induced Hepatotoxicity and Protection
- Metabolism and Genetic Disorders
- Diet, Metabolism, and Disease
- Neuropeptides and Animal Physiology
- Biochemical effects in animals
- Metabolomics and Mass Spectrometry Studies
- Psychedelics and Drug Studies
Norwegian Institute of Public Health
2016-2025
University of Oslo
2016-2025
Bexar County Medical Examiner's Office
2020
Norwegian Medical Association
2019
Institutt for Eksperimentell Medisinsk Forskning
2019
Oslo University Hospital
1988-2018
Inland Hospital
2018
Forskning.no (Norway)
2017
DMA Health Strategies
2017
Ruralis - Institute for Rural and Regional Research
2017
ABSTRACT Aim A major problem in assessing the true public health impact of drug‐use on driving and overall traffic safety is that variables being measured across studies vary significantly. In reported a growing global literature, basic parameters assessed, analytical techniques drugs tested are simply not comparable due to lack standardization field. These shortcomings severely limit value this research add knowledge set standards harmonize findings sorely needed. This project was initiated...
Background: The quantitative measurement of urinary metabolites in sewage streams and the subsequent estimation consumption rates parent compounds have previously been demonstrated for pharmaceuticals narcotics. Ethyl sulfate ethyl glucuronide are excreted urine following ingestion alcohol, useful biomarkers identification acute alcohol consumption. This study reports a novel ion-exchange-mediated chromatographic method effluent, presents calculation purposes relating resulting...
Aim: Urinary ethyl glucuronide (EtG), sulfate (EtS), and the ratio between 5-hydroxytryptophol-glucuronide 5-hydroxyindole-3-acetic acid (GTOL/5-HIAA) are all suggested as biomarkers for recent alcohol ingestion with longer detection times than measurement of ethanol itself. The aim this controlled study was to compare sensitivities EtG, EtS, GTOL/5-HIAA, after a single ethanol. Methods: 0.5 g ethanol/kg body weight ingested by 10 healthy male volunteers in fasted state. Ethanol, GTOL/HIAA...
Abstract. The effect of indomethacin (2 mg/kg/day) on the healing closed unimmobilized femoral fractures was examined in rats. A standard fracture produced 205 male adolescent rats, and three different experiments were done. In a long‐term experiment, rats treated with either or placebo for 29 days followed maximum 91 days. two short‐term experiments, week 122 age studied one experiment. Indomethacin plasma levels about 1 μg/ml indomethacin‐treated animals. inhibited ( P < 0·006)...
The purpose of this study was to establish and validate a driving simulator method for assessing drug effects on driving. To achieve this, we used ethanol as positive control, examined whether affects performance in the simulator, these are consistent with during real test track, also under influence ethanol. Twenty healthy male volunteers underwent total six trials 1 h duration; three an instrumented vehicle closed-circuit track that closely resembled rural Norwegian road conditions,...
ABSTRACT Aims Studies have shown that the impairing effects of Δ‐9‐tetrahydrocannabinol (THC) are dose‐related. Cannabis intake increases risk traffic accidents. The purpose this study was to see how different clinical tests and observations were related blood THC concentrations determine whether combined influence ethanol from either drug alone. Design A retrospective cross‐sectional forensic database study. Setting Drivers apprehended by police suspected driving under alcohol other drugs....
Heroin, with low affinity for μ-opioid receptors, has been considered to act as a prodrug. In order study the pharmacokinetics of heroin and its active metabolites after i.v. administration, we gave bolus injection rats measured concentration in blood brain extracellular fluid (ECF).After an freely moving Sprague-Dawley rats, concentrations samples from vena jugularis microdialysis striatal ECF were by ultraperformance LC-MS/MS.Heroin levels decreased very fast, both ECF, could not be...
In this article the methodological basis for our knowledge within field of driving under influence non-alcohol drugs is reviewed. The experimental and epidemiological studies on in relation to do not constitute a complete conclusions be drawn, but give at present state nevertheless platform indicate increased hazard connected with use several drugs. It appears that main problem respect therapeutic medicinal experienced benzodiazepines (BZDs) related drugs, lesser extent opioids...
Abstract Background Benefits of elevated high-density lipoprotein cholesterol (HDL-C) levels are challenged by reports demonstrating U-shaped relations between HDL-C and all-cause mortality; the association with cause-specific mortality is less studied. Methods A total 344 556 individuals (20–79 years, 52 % women) recruited from population-based health screening during 1985–2003 were followed until end 2018 for serum level at inclusion &lt;30, 30–39, 40–49, 50–59, 60–69, 70–79, 80–89,...
Urinary excretion of 11-nor-9-carboxy-Δ9-tetrahydrocannabinol (THCCOOH) and cannabinoids was monitored in prison inmates. specimens were collected up to five times per day. EMIT™ (cutoff 20 ng/mL; EMIT20) gas chromatography (GC) 10.3 ng/mL, LOD 1.4 ng/mL) used for cannabinoid screening THCCOOH confirmation, respectively. creatinine concentrations recorded. Of the samples with positive EMIT screens, 78% confirmed by GC analysis. The plotting THCCOOH/creatinine ratios (THCCOOH/C) versus time...
Femoral blood is widely accepted as the most reliable postmortem specimen for drug analysis in forensic toxicology. There considerable evidence that concentrations peripheral samples are closer to antemortem level than concentration cardiac blood. In present study measured femoral and/or heart from eight cases were compared with found serum same subject collected or perimortem. The drugs involved amitriptyline, nortriptyline, imipramine, verapamil and chloroquine. Two additional very early...