A5046449202- Systemic Sclerosis and Related Diseases
- Systemic Lupus Erythematosus Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Inflammatory Myopathies and Dermatomyositis
- Autoimmune and Inflammatory Disorders Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Liver Disease Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Liver Disease and Transplantation
- Osteoarthritis Treatment and Mechanisms
- Microscopic Colitis
- Inflammasome and immune disorders
- Inflammatory Bowel Disease
- Sarcoidosis and Beryllium Toxicity Research
- Gut microbiota and health
- Dermatologic Treatments and Research
- Nutritional Studies and Diet
- Diet and metabolism studies
- Skin Diseases and Diabetes
- T-cell and B-cell Immunology
- Hypertrophic osteoarthropathy and related conditions
- Muscle metabolism and nutrition
- Periodontal Regeneration and Treatments
Grigore T. Popa University of Medicine and Pharmacy
2015-2024
Clinical Emergency Hospital Bucharest
2015-2024
Rheumatoid arthritis (RA) is a chronic autoimmune condition frequently found in rheumatological patients that sometimes raises diagnosis and management problems. The pathogenesis of the disease complex involves activation many cells intracellular signaling pathways, ultimately leading to innate acquired immune system producing extensive tissue damage. Along with joint involvement, RA can have numerous extra-articular manifestations (EAMs), among which lung damage, especially interstitial...
The importance of intestinal microbiota in the development various systemic diseases has been highlighted over time. Ankylosing spondylitis (AS) is a disease with complex pathogenesis involving particular genetic marker and distinctive environmental triggers such as specific gut dysbiosis. We conducted prospective case‑control study which included 60 subjects from Iasi Rehabilitation Hospital: 28 AS cases 32 healthy controls. Intestinal analysis was performed by real‑time polymerase chain...
Relapsing polychondritis is a chronic autoimmune inflammatory condition characterized by recurrent episodes of inflammation at the level cartilaginous structures and tissues rich in proteoglycans. The pathogenesis disease complex still incompletely elucidated. data support important role particular genetic predisposition, with HLA-DR4 being considered an allele that confers major risk occurrence. Environmental factors, mechanical, chemical or infectious, act as triggers development clinical...
Rheumatoid arthritis (RA) is a systemic immune-mediated disease that, in addition to the articular involvement, can have extra-articular manifestations. Even though liver damage RA not very common, associated autoimmune diseases (AILDs) may occur. The most common AILD with primary biliary cirrhosis (PBC), followed by hepatitis (AIH) and sclerosing cholangitis (PSC). There are underlying mechanisms that play role emergence of autoimmunity inflammation both rheumatic diseases. Genetic studies...
Both inflammatory bowel diseases (IBD) and ankylosing spondylitis (AS) can be considered chronic immune disorders sharing common etiopathogenetic mechanisms. Changes in the composition of intestinal microbiota, which lead to an abnormal mucosal response, could missing link between these two diseases. Our study evaluate microbiota characterize gut dysbiosis patients with IBD AS.We conducted a prospective case-control that enrolled 124 [20 Crohn's disease (CD), 27 ulcerative colitis (UC), 28...
Background: Pregnancy in women with systemic lupus erythematosus (SLE) is accompanied by adverse pregnancy outcomes (APOs). We aimed to investigate the association between clinical, sonographic, and laboratory parameters APOs (preeclampsia, intrauterine growth restriction, premature birth, maternal mortality). Methods: This observational retrospective study included all pregnancies SLE who attended two tertiary maternity hospitals from Romania January 2013 December 2020. Clinical, variables...
Systemic sclerosis (SSc) patients exhibit a plethora of risk factors for nutritional decline, including the presence chronic inflammation and progressive nature disease-related multisystem involvement. The prevalence consequences decline in scleroderma are frequently underestimated, its management currently remaining subject debate. main objective present study was to perform detailed assessment patients' diet as well their eating habits describe relationships with weight loss malnutrition...
Osteoarthritis (OA) is a condition that can cause substantial pain, loss of joint function, and decline in quality life patients. Numerous risk factors, including aging, genetics, injury, have role the onset OA, characterized by structural changes within joints. Most therapeutic approaches focus on symptoms try to change or improve structure tissues. Even so, no treatments been able stop slow progression OA give effective long-lasting relief symptoms. In absence disease-modifying drugs,...
A novel cationic associating pullulan derivative (DBAP-P) was synthesized using as hydrophilic backbone and (dibuthylamino)propyl carbamate groups pendant hydrophobic segments.The structural characteristics of this polymer were investigated by FT-IR, 1 H-and 13 C-NMR spectroscopy.The degree substitution found to be 0.36 moieties per unit pullulan.The intrinsic viscosity the DBAP-P sample calculated Fedors' Wolf's models.The critical aggregation concentration (cac) value 0.1 g/dL determined...
Systemic sclerosis (SSc) is a rare and complex autoimmune disease associated with poor vital functional outcomes. The hindrance in patients derives from various disease-specific manifestations, including Raynaud's phenomenon digital ulcers (DUs). Bosentan an endothelin receptor antagonist capable of preventing the appearance new DUs scleroderma. present study aimed to evaluate effects on severity phenomenon, DU-related symptoms impairment during first year treatment. A prospective that...
Modern lifestyles have led to sedentary behavior, lower participation in active movement and physical activities during leisure time, unhealthy diets, increased exposure stress. It is important examine the interaction of several lifestyle risk factors instead focusing on one alone. The purpose this study was identify patterns a group patients with type 2 diabetes associations its components certain metabolic parameters. Using principal component analysis, we identified three dietary...