A5072745535- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Spondyloarthritis Studies and Treatments
- Systemic Sclerosis and Related Diseases
- Psoriasis: Treatment and Pathogenesis
- Osteoarthritis Treatment and Mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inflammatory Myopathies and Dermatomyositis
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Autoimmune and Inflammatory Disorders Research
- Bone health and osteoporosis research
- Sarcoidosis and Beryllium Toxicity Research
- Liver Disease Diagnosis and Treatment
- Vasculitis and related conditions
- Periodontal Regeneration and Treatments
- Bone and Joint Diseases
- Viral Infections and Immunology Research
- Dental Anxiety and Anesthesia Techniques
- Gout, Hyperuricemia, Uric Acid
- Inflammatory Bowel Disease
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Eosinophilic Disorders and Syndromes
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cytokine Signaling Pathways and Interactions
Grigore T. Popa University of Medicine and Pharmacy
2015-2025
Clinical Emergency Hospital Bucharest
2018-2025
Abdelmalek Essaâdi University
2023
Institutul Cantacuzino
2018
MSD (France)
2017
Roche (Switzerland)
2017
AbbVie (United States)
2017
Pfizer (United States)
2017
Biogen (Switzerland)
2017
Janssen (Belgium)
2017
Rheumatoid arthritis (RA) is a chronic autoimmune condition frequently found in rheumatological patients that sometimes raises diagnosis and management problems. The pathogenesis of the disease complex involves activation many cells intracellular signaling pathways, ultimately leading to innate acquired immune system producing extensive tissue damage. Along with joint involvement, RA can have numerous extra-articular manifestations (EAMs), among which lung damage, especially interstitial...
Interleukin-10 (IL-10) presents a dual role in systemic lupus erythematosus (SLE), illustrating pro-inflammatory and anti-inflammatory effects. This study addressed the possible associations between serum IL-10 levels demographic characteristics, laboratory parameters, organ manifestations, disease activity, treatment response SLE patients. A total of 88 patients from Rheumatology Clinic Clinical Rehabilitation Hospital, Iași, were enrolled. Disease activity was assessed using Systemic Lupus...
Relapsing polychondritis is a chronic autoimmune inflammatory condition characterized by recurrent episodes of inflammation at the level cartilaginous structures and tissues rich in proteoglycans. The pathogenesis disease complex still incompletely elucidated. data support important role particular genetic predisposition, with HLA-DR4 being considered an allele that confers major risk occurrence. Environmental factors, mechanical, chemical or infectious, act as triggers development clinical...
Rheumatoid arthritis (RA) is a systemic immune-mediated disease that, in addition to the articular involvement, can have extra-articular manifestations. Even though liver damage RA not very common, associated autoimmune diseases (AILDs) may occur. The most common AILD with primary biliary cirrhosis (PBC), followed by hepatitis (AIH) and sclerosing cholangitis (PSC). There are underlying mechanisms that play role emergence of autoimmunity inflammation both rheumatic diseases. Genetic studies...
Systemic sclerosis (SSc) patients exhibit a plethora of risk factors for nutritional decline, including the presence chronic inflammation and progressive nature disease-related multisystem involvement. The prevalence consequences decline in scleroderma are frequently underestimated, its management currently remaining subject debate. main objective present study was to perform detailed assessment patients' diet as well their eating habits describe relationships with weight loss malnutrition...
Osteoarthritis (OA) is a condition that can cause substantial pain, loss of joint function, and decline in quality life patients. Numerous risk factors, including aging, genetics, injury, have role the onset OA, characterized by structural changes within joints. Most therapeutic approaches focus on symptoms try to change or improve structure tissues. Even so, no treatments been able stop slow progression OA give effective long-lasting relief symptoms. In absence disease-modifying drugs,...
The fight against smoking through various cessation methods could be very effective by early education especially in young people for preventing the occurrence or severity of obstructive lung diseases. aim study was to present impact varenicline, a selective partial nicotine agonist, adults 40-49 year-old, active smokers, recently diagnosed with COPD, from 2009 2011, Smoking Cessation Center Pulmonary Rehabilitation Clinic Iasi, Romania. There were included all male employees, without...
Many of the chemical additives in plastic products, besides possible safety problems that may arise during production process, have negative effecty, too, on environment and human health. Plastic is a synthetic polymer. The polymers include starch, latex cellulose, combined with different substances chemicals, used various formulas, polymer included naylon. At high temperatures such as microwave oven temperature, can migrate from packaging food. In most cases, establishing diagnosis allergic...
In the present work, LC- Q ExactiveOrbitrap high resolution MS techique in both full-scan and targeted MS/MS modes was applied to identify psychoactive substances human urine samples. Methylenedioxy-pyrovalerone (MDPV), methylenedioxy-alpha-pyrrolidino-butyrophenone(MDPBP) main metabolites of compounds were identified. The preliminary screening folowed by ion fragmentation (t-MS2) enabling confirmatory analysis mass spectral characterization. presented case is first confirmation MDPBP abuse...
The aim of the present study was to characterize antibiotic resistance profile enterobacteriaceae strains isolated in Infectious Diseases Hospital Galati, Romania, during 2016, order guide local stewardship strategy. There are 597 biological samples with positive cultures for enterobacteriaceae, related invasive and non-invasive infections. main bacterial genus were E. coli 62%, Klebsiella spp 15%, Proteus 11% Salmonella 6%. Over a half have one or more resistance. level depends on genus,...