A5052108452- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Nerve injury and regeneration
- Neuroscience and Neuropharmacology Research
- Insect and Pesticide Research
- Pesticide Exposure and Toxicity
- Biochemical and biochemical processes
- Cholinesterase and Neurodegenerative Diseases
- Nuclear Receptors and Signaling
- Environmental Toxicology and Ecotoxicology
- Memory and Neural Mechanisms
- Neurogenetic and Muscular Disorders Research
- Pain Mechanisms and Treatments
- Olfactory and Sensory Function Studies
- Pharmacological Effects of Natural Compounds
- Medicinal Plants and Neuroprotection
- Alzheimer's disease research and treatments
- Electrochemical Analysis and Applications
- Stress Responses and Cortisol
- Amyotrophic Lateral Sclerosis Research
- Transcranial Magnetic Stimulation Studies
- Essential Oils and Antimicrobial Activity
- Botulinum Toxin and Related Neurological Disorders
- Conducting polymers and applications
Universidade Federal de Sergipe
2017-2025
Parkinson's disease (PD) is a neurodegenerative characterized by progressive degeneration of dopaminergic neurons in the substantia nigra pars compact (SNpc), with consequent depletion dopamine striatum, which gives rise to characteristic motor symptoms PD. Although its etiology unknown, several studies have suggested that oxidative stress plays critical function pathophysiology PD, and antioxidant agents could be helpful slown down neurodegeneration. Carvacrol (CA) phenolic monoterpene...
Evidence indicates that oxidative stress has an important role in the onset and progression of Parkinson's disease (PD). Antioxidant agents from natural products have shown neuroprotective effects animal models PD. Eplingiella fruticosa is aromatic medicinal plant Lamiaceae family include culinary herbs. The essential oil (EPL) anti-inflammatory antioxidant activities. Cyclodextrins are used to enhances pharmacological profile oil. We obtained EPL leaves complexed with β-cyclodextrin...
Parkinson's disease (PD) is a neurodegenerative related to the dopaminergic system. The etiology not fully understood, but it known that PD multifactorial involves genetic and environmental factors, including pesticides. One of these, Deltamethrin (DM), has been widely used for vector control in crops, farming, veterinary medicine domestic pest control. purpose present study was investigate effect DM repeated administration on motor, cognitive emotional behavior parameters. Male Wistar rats...
Orofacial pain is one of the commonest and most complex complaints in dentistry, greatly impairing life quality. Preclinical studies using monoterpenes have shown pharmacological potential to treat painful conditions, but reports effects myrtenol on orofacial inflammation are scarce. The aim this study was evaluate effect experimental models inflammation. nociceptive behavior immunoreactivity phosphorylated p38 (P-p38)-MAPK trigeminal ganglia (TG) spinal subnucleus caudalis (STSC) were...
Parkinson's disease (PD) is mostly known as a dopamine deficiency syndrome due the structural and functional changes in striatal projection neurons. However, studies have considered this pathology multi-systemic which neurodegenerative process extends beyond dopaminergic system. Therefore, purpose of present study was to investigate morphological immunohistochemical associated with behavioral cognitive alterations model parkinsonism induced by low dose reserpine. Animals showed anxiety-like...
Deltamethrin (DM) is widely used in agriculture, veterinary medicine and control of domestic pests. Epidemiological studies suggest that DM exposure a risk factor for neurodegenerative disorders such as Parkinson's (PD) Alzheimer diseases; however the mechanisms are elusive. In present study we evaluated effects intracerebroventricular (i.c.v.) administration on locomotion activity, spatial working memory dopaminergic pathway rat. Middle-aged male Wistar rats received three i.c.v. injections...
Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease associated with loss of upper and lower motor neurons in the primary cortex spinal cord, respectively. Motor deficits are main clinical features observed patients disease. However, it has been suggested that presence neurotoxic factors cerebrospinal fluid (CSF) from ALS causes neurons. The present study investigated histopathological changes induced by intracerebroventricular (ICV) infusion CSF middle aged male...