A5051236045- Neuroinflammation and Neurodegeneration Mechanisms
- Olfactory and Sensory Function Studies
- Immune Response and Inflammation
- Immune cells in cancer
- Advanced Chemical Sensor Technologies
- Biochemical Analysis and Sensing Techniques
- Tryptophan and brain disorders
- S100 Proteins and Annexins
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Inflammatory mediators and NSAID effects
- Neonatal and fetal brain pathology
- Stress Responses and Cortisol
- Gut microbiota and health
- Chemokine receptors and signaling
- Barrier Structure and Function Studies
- Parkinson's Disease Mechanisms and Treatments
- Long-Term Effects of COVID-19
- Mitochondrial Function and Pathology
- Genetics, Aging, and Longevity in Model Organisms
- Microbial infections and disease research
- Bacteriophages and microbial interactions
- Peroxisome Proliferator-Activated Receptors
- Neurogenesis and neuroplasticity mechanisms
- Immune Cell Function and Interaction
Kyorin University
2018-2024
Tokyo Institute of Technology
2022
Pennsylvania State University
2016-2019
Kyorin (United States)
2019
Penn State Milton S. Hershey Medical Center
2016-2018
Japan Society for the Promotion of Science
2012-2016
Aichi Human Service Center
2010-2015
Nagoya University
2010-2015
Abstract The olfactory mucosa (OM) is exposed to environmental agents and therefore vulnerable inflammation. To examine the effects of toxin-initiated OM inflammation on bulb (OB), we induced persistent rhinitis in mice analyzed spatial temporal patterns histopathological changes OB. Mice received unilateral intranasal administration lipopolysaccharide (LPS) or saline three times per week, were immunohistologically at 1, 3, 7, 14 21 days after first administration. LPS an inflammatory...
Abstract The impact of SARS-CoV-2 on the olfactory pathway was studied over several time points using Syrian golden hamsters. We found an incomplete recovery sensory neurons, prolonged activation glial cells in bulb, and a decrease density dendritic spines within hippocampus. These data may be useful for elucidating mechanism underlying long-lasting dysfunction cognitive impairment as post-acute COVID-19 syndrome.
Systemic inflammation shifts the brain microenvironment towards a proinflammatory state. However, how peripheral mediates changes in remains to be clarified. We aimed identify hippocampal cells and cytokines that respond endotoxemia. Mice were intraperitoneally injected with lipopolysaccharide (LPS) or saline, examined 1, 4, 24 h after injection. Tissue cytokine concentrations spleens hippocampi determined by multiplex assays. Another group of mice studied immunohistologically. Fourteen...
Chronic stress can impair the health of human brains. An important strategy that may prevent accumulation be consumption functional foods. When senescence-accelerated mice prone 10 (SAMP10), a stress-sensitive strain, were loaded with using imposed male mouse territoriality, brain volume decreased. However, in ingested theanine (6 mg/kg), main amino acid tea leaves, atrophy was suppressed, even under stress. On other hand, not clearly observed strain aged normally (Slc:ddY). The expression...
Sepsis-associated encephalopathy (SAE) is characterized as diffuse brain dysfunction in patients with excessive systemic inflammatory reaction to an infection. In our previous studies using a mouse model of SAE intraperitoneal injection lipopolysaccharide (LPS), tissue concentrations various cytokines were elevated the entire parenchyma 4 and 24 h following LPS administration. Cytokines at produced by choroid plexus, leptomeninges vascular endothelium, while those astrocytes. Interleukin...
Multiple system atrophy (MSA) is pathologically characterized by the formation of α-synuclein-containing glial cytoplasmic inclusions (GCIs) in oligodendrocytes. However, mechanisms GCI are not fully understood. Cellular machinery for aggresomes has been linked to biogenesis Lewy body, a characteristic inclusion Parkinson's disease and dementia with bodies. Here, we examined whether GCIs contain components immunohistochemistry.Sections from five patients MSA were stained...
N iemann‐ P ick disease type C ( NPC ) is an autosomal recessive neurovisceral lipid storage disorder. Two disease‐causing genes NPC1 and NPC2 have been identified. characterized by neuronal glial NFTs . Here, we report a man with juvenile‐onset progressive neurological deficits, including pyramidal signs, ataxia, bulbar palsy, vertical supranuclear ophthalmoplegia, psychiatric symptoms; death occurred at age 37 before definitive clinical diagnosis. Post mortem gross examination revealed...
Although the brain is now known to actively interact with immune system under non-inflammatory conditions, site of cell-cell interactions between parenchymal cells and has been an open question until recently. Studies by our other groups have indicated that structures such as leptomeninges, choroid plexus stroma epithelium, attachments plexus, vascular endothelial cells, perivascular space, circumventricular organs, astrocytic endfeet construct histological architecture provides a location...
Harmful environmental agents cause nasal inflammation, and chronic inflammation induces a loss of olfactory sensory neurons (OSNs) reversible atrophy the bulb (OB). Here, we investigated mechanisms underlying this inflammation-induced OB by histologically biochemically comparing changes in mouse models odor deprivation. In addition, examined whether stimulation is necessary for recovery from atrophy. One group adult male C57BL/6 mice was administered lipopolysaccharide (LPS) unilaterally 10...
Abstract Background Senescence-accelerated mice (SAM) are a series of mouse strains originally derived from unexpected crosses between AKR/J and unknown mice, which phenotypically distinct senescence-prone (SAMP) -resistant (SAMR) inbred were subsequently established. Although SAMP have been widely used for aging research focusing on their short life spans various age-related phenotypes, such as immune dysfunction, osteoporosis, brain atrophy, the responsible gene mutations not yet fully...
The ageing brain is characterized by degenerative changes in both neurons and glia. Although are known to lose dendritic complexity with ageing, age-related the morphology of microglia have not been well documented. We investigated potential microglial using mouse models. Senescence-accelerated prone 10 (SAMP10) which neuronal degeneration begins appear around 8 months age becomes progressively remarkable advancing was used as a model ageing. resistant 1 (SAMR1) inconspicuous usual-ageing...
Abstract There is an urgent need to develop phage therapies for multidrug-resistant bacterial infections. However, although bacteria have been shown be susceptible therapy, therapy not sufficient in some cases. PhiMR003 a methicillin-resistant Staphylococcus aureus previously isolated from sewage influent, and it has demonstrated high lytic activity broad host range MRSA clinical isolates vitro. To investigate the potential of phiMR003 treatment infection, effects on immune responses vivo...
Circulating endotoxins including lipopolysaccharides (LPS) cause brain responses such as fever and decrease of food water intake, while pre-injection attenuates these responses. This phenomenon is called endotoxin tolerance, but the mechanisms underlying it remain unclear. The subfornical organ (SFO) rapidly produces proinflammatory cytokines interleukin-1β (IL-1β) in response to peripherally injected LPS, repeated LPS injection IL-1β production SFO, indicating that SFO involved tolerance....
By comprehensively measuring changes in metabolites the hippocampus of stress-loaded mice, we investigated reasons for stress vulnerability and effect theanine, i.e., an abundant amino acid tea leaves, on metabolism. Stress sensitivity was higher senescence-accelerated mouse prone 10 (SAMP10) mice than normal ddY when these were loaded with basis territorial consciousness males. Group housing used as low-stress condition reference. Among statistically altered metabolites, depression-related...
Brain research has progressed with anesthetized animal experiments for a long time. Recent progress in techniques allows us to measure neuronal activity awake animals combined behavioral tasks. The trends became more prominent the last decade. This new style triggers paradigm shift of brain science, and insights into function have been revealed. It is reasonable consider that are ideal understanding naturalistic than ones. However, experiment still advantages some experiments. To take...
The olfactory epithelium (OE) is directly exposed to environmental agents entering the nasal cavity, leaving OSNs prone injury and degeneration. causes of dysfunction are diverse include head trauma, neurodegenerative diseases, aging, but main chronic rhinosinusitis (CRS) viral infections. In CRS infections, reduced airflow due local inflammation, inflammatory cytokine production, release degranulated proteins from eosinophils, cell lead decreased function. It well known that injury-induced...