A5053391127- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Click Chemistry and Applications
- Chemical Synthesis and Analysis
- Cancer therapeutics and mechanisms
- Synthesis and biological activity
- Receptor Mechanisms and Signaling
- Antibiotic Resistance in Bacteria
- Fungal Plant Pathogen Control
- Renin-Angiotensin System Studies
- Protein Hydrolysis and Bioactive Peptides
- Neuropeptides and Animal Physiology
- Microbial Natural Products and Biosynthesis
- Antimicrobial Peptides and Activities
- RNA and protein synthesis mechanisms
- Carbohydrate Chemistry and Synthesis
- Tuberculosis Research and Epidemiology
- Antimicrobial Resistance in Staphylococcus
- Crystallography and molecular interactions
New York University
2021-2022
National Chemical Laboratory
2013-2018
Savitribai Phule Pune University
2015-2016
Institute of Genomics and Integrative Biology
2015
Chemical Synthesis Lab
2015
We describe herein the design, synthesis and conformational investigation of Pro-Amb (proline-3-amino-2-methoxybenzoic acid) incorporated Angiotensin II its truncated analogues. Solution-state NMR CD studies suggest γ-turn-like conformation in analogs aqueous solution. Furthermore, have been shown to act as AT2 receptor agonists.
Abstract Ureidopenicillins are a class of penicillins which antibiotics active against gram‐negative bacteria. Herein, we report the synthesis 2‐aminothiophene‐tethered ureidopenicillin analogues and their in vitro antibacterial antitubercular activity. Intriguingly, unlike reported ureidopenicillins bacteria, synthesised were significantly Gram‐positive bacterial strains showed moderate inhibition towards strains. Among all analogs, compound 1 b containing 2‐aminothiophene moiety with...
This communication describes the competition between native β-turn (C10) and 2-aminobenzenesulfonic acid (<sup>S</sup>Ant)(orthanilic acid)-based pseudo (C11) in their hybrid peptides.