A5062266738- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Cardiac and Coronary Surgery Techniques
- Cardiac Structural Anomalies and Repair
- Congenital Heart Disease Studies
- Coronary Interventions and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- Coronary Artery Anomalies
- Cardiac pacing and defibrillation studies
- Mechanical Circulatory Support Devices
- Cardiovascular Function and Risk Factors
- Cardiac Health and Mental Health
- Healthcare Regulation
- COVID-19 Impact on Reproduction
- Cardiovascular and Diving-Related Complications
- Cardiovascular Effects of Exercise
- Vascular anomalies and interventions
- Cardiomyopathy and Myosin Studies
- Healthcare during COVID-19 Pandemic
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Imaging and Diagnostics
- Cardiac Arrhythmias and Treatments
- Infectious Aortic and Vascular Conditions
- Diversity and Career in Medicine
Instituto Dante Pazzanese de Cardiologia
2012-2024
Hospital do Coração
1993-2024
Universidade de São Paulo
2003-2024
Universitario Francisco de Asís
2024
Sociedade Brasileira de Cardiologia
2023
Universidade Federal do Rio de Janeiro
2023
Universidade Federal do Rio Grande do Norte
2021
Surgical Specialties (United States)
2021
Medicina
2009
Medico
2007-2008
The Down syndrome (DS) immune phenotype is characterized by thymus hypotrophy, higher propensity to organ-specific autoimmune disorders, and susceptibility infections, among other features. Considering that AIRE (autoimmune regulator) located on 21q22.3, we analyzed protein gene expression in surgically removed thymuses from 14 DS patients with congenital heart defects, who were compared 42 age-matched controls anomaly as an isolated malformation. Immunohistochemistry revealed 70.48 ± 49.59...
Os avanços recentes no uso de exossomos e nanotecnologia têm demonstrado grande potencial terapêutico tratamento da aterosclerose. Exossomos derivados diferentes tipos celulares, como células-tronco mesenquimais, células progenitoras endoteliais, macrófagos medula óssea plaquetas, desempenham um papel fundamental na modulação inflamação, regulação apoptose promoção reparação vascular. A presença microRNAs específicos nesses influencia vias inflamatórias oxidativas críticas, contribuindo para...
O Transtorno Bipolar (TB) infantil é uma condição psiquiátrica complexa que, embora compartilhe os mesmos critérios diagnósticos do CID-10 e DSM-5 para todas as idades, apresenta características específicas na população pediátrica. Crianças adolescentes com TB apresentam um quadro clínico distinto, sintomas como irritabilidade, labilidade de humor comorbidade Déficit Atenção Hiperatividade (TDAH) mais frequentes que em adultos. Além disso, a doença inicia, comumente, episódios depressivos, o...
The quality of data in electronic healthcare databases is a critical component when used for research and health practice. aim the present study was to assess Paulista Cardiovascular Surgery Registry II (REPLICCAR II) using two different audit methods, direct indirect. REPLICCAR database contains from 9 hospitals São Paulo State with over 700 variables 2229 surgical patients. collection performed REDCap platform trained managers abstract information. We directly audited random sample (n =...
The thymus is the site of T cell maturation. Notch receptors (Notch1-4) and ligands (DLL1-3 Jagged1-2) constitute one several pathways involved in this process. Our data revealed differential constitutive expression genes lymphocytes thymic dendritic cells (tDCs), suggesting their participation human thymocyte nTreg analyses indicated that components function parallel to promote maturation thymus.
Introduction: Active infective endocarditis is associated with high morbidity and mortality.Surgery indicated in high-risk conditions, the main determinants of mortality surgical treatment should be evaluated.Objective: To identify predictors active a long-term follow-up.Methods: This prospective observational study involved 88 consecutive patients diagnosed endocarditis, who underwent surgery between January 2005 December 2015.Fifty-eight (65.9%) were male, mean age was 50.87±16.15years.A...
We sought to compare the new transcatheter aortic valve replacement (TAVR) device ACURATE neo (ACT) with already established CoreValve (MCV) and SAPIEN XT (SXT) for treatment of severe stenosis (AS).Very few data on TAVR devices are available beyond MCV there is no previous study comparing ACT SXT.We prospectively evaluated consecutive patients who underwent transfemoral AS. Clinical outcomes were reported following Valve Academic Research Consortium 2 (VARC-2) criteria.A total 162 (ACT n =...
Objectives The objectives of the present study were to analyze variation renal function after transcatheter aortic valve replacement (TAVR) focused on acute kidney injury (AKI) and its impact short‐ mid‐term mortality. Background Changes TAVR their clinical outcomes are incompletely understood until now. Methods At two tertiary centers 221 consecutive patients submitted TAVR. Kidney was defined according VARC‐2 criteria. Patients classified presence (group 1) or absence 2) AKI. Creatinine...
Intraoperative blood salvage (cell saver technique) in cardiac surgery is universally used surgical procedures with a marked risk of loss. The primary objectives this study were to determine the concentration residual heparin final product that reinfused into patient operating room and evaluate efficacy safety cell technique.Twelve patients undergoing elective enrolled study. Using XTRA Autotransfusion System, samples collected from cardiotomy reservoir, both prior processing (pre-sample)...
Youth-led participatory action research (YPAR) is a collaborative approach for engaging young people as experts and leaders in the process. The purpose of this study to showcase potential methodology tool social justice equity work schools. First, we review transformative critical paradigms that underpin YPAR approach. Second, provide an illustration project on youth well-being during COVID-19 pandemic (May–June 2020). Participants included 375 middle- high-school students living...
Atrial fibrillation is the main complication in postoperative period of cardiovascular surgery. Its genesis multifactorial, so its rapid identification to mitigate associated risks essential.
Coronary artery bypass grafting using both internal mammary arteries in patients with diabetes mellitusRevascularização do miocárdio com emprego de ambas artérias mamárias internas em pacientes mellitus Resumo Objetivo: Descrever a utilização (MIs) submetidos à operação revascularização (RM), que sejam portadores (DM).Método: No período compreendido entre janeiro 1995 e agosto 2005, 4.569 foram RM nossa instituição, sendo 1.298 eram DM.A média idade era 62 anos, mortalidade global foi 2,18%...
Aortic stenosis is the most common native valve disease, affecting up to 5% of elderly population. Surgical aortic replacement reduces symptoms and improves survival, definitive therapy in patients with symptomatic severe stenosis. However, despite good results classic surgery, risk markedly increased co-morbidities. Transcatheter (TAVR) allows implantation a prosthetic heart within diseased without need for open surgery cardiopulmonary bypass, offering new therapeutic option considered at...
Resumo Fundamento A COVID-19 adicionou um fardo enorme sobre os médicos ao redor do mundo, especialmente as mulheres médicas, que são afetadas pelo aumento da carga de trabalho e pela perda qualidade vida. Objetivo Avaliar efeitos pandemia na vida, burnout espiritualidade médicas brasileiras atendem pacientes com direta ou indiretamente. Método Estudo prospectivo, observacional realizado 28 julho a 27 setembro 2020, no Brasil, [...]
Introduction: Advances in modern medicine have led to people living longer and healthier lives.Frailty is an emerging concept yet be explored as a risk factor cardiac surgery.When it comes CABG surgery, randomized controlled clinical trials primarily focused on low-risk (ROOBY, CORONARY), elevated-risk (GOPCABE) or high-risk patients (BBS), but not frail patients.Therefore, we believe that off-pump could important technique with limited functional capacity respond surgical stress.In this...
Abstract Objectives The aim of the study was to evaluate mid‐ late clinical and echocardiographic outcomes after transcatheter aortic valve replacement (TAVR) with Acurate neo ™ (Boston Scientific, Boston, MA). Background TAVR is an established treatment for stenosis (AS). Few data exist on long‐term durability new‐generation valves. Methods All consecutive patients ( n = 104) who underwent implantation from 2012 2018 were included. Follow‐up systematically performed at 1, 6, 12, 24 months...
Objective: Elaboration and internal validation of the Quality Life in Cardiovascular Surgery (QLCS) questionnaire adapted to reality Brazilian cardiovascular surgery.Methods: Cross-sectional pilot study a prospective cohort included Documentation Surgical Registry Center (CEDREC) for QLCS questionnaire.Four hundred forty-five patients submitted surgery who answered 30 days after hospital discharge were included.It was applied via telephone.To verify questions' consistency, Cronbach's alpha...
Introduction: Replacement of the aortic valve in patients with a small annulus is associated increased morbidity and mortality.A prosthesis-patient mismatch one main problems failed valves this patient population.Objective: To evaluate long-term mortality predictors undergoing replacement bioprosthesis.Methods: In retrospective observational study, total 101 from January 2000 to December 2010 were studied.There 81 (80.19%) women mean age 52.81±18.4years.Severe stenosis was indication for...
Introduction:The great saphenous vein is widely used as a graft in coronary artery bypass grafting surgery.Complications due to harvesting can be minimized when using ultrasonography mapping and marking.Objective: To analyze by clinical trial the use of vascular map determine viability dissection site.Methods: A total 151 consecutive patients submitted surgery with were selected for this prospective study.They divided into two groups: Group 1 -84 ultrasonographic marking vein; 2 -67 had...
Objetivo O objetivo primordial desse documento e estimular a melhoria das condicoes de saude mulheres brasileiras, com foco na doenca cardiovascular (DCV). A DCV responsavel por 17,5 milhoes mortes prematuras/ano no mundo, previsao aumento para 23 em 2030. As sao responsaveis um terco todas as Brasil, semelhanca entre homens apos menopausa. Esses dados revestem-se maior importância quando consideramos que 80% prematuras poderiam [...]