A5065388903- Marine Biology and Environmental Chemistry
- Antimicrobial agents and applications
- Antimicrobial Peptides and Activities
- Chemical Synthesis and Analysis
- Synthesis and Biological Evaluation
- Environmental Chemistry and Analysis
- RNA and protein synthesis mechanisms
- Marine Ecology and Invasive Species
- Marine Sponges and Natural Products
- Biochemical and Structural Characterization
University of Auckland
2019-2023
ConspectusThe alarming rate at which micro-organisms are developing resistance to conventional antibiotics represents one of the global challenges our time. There is currently ample space in antibacterial drug pipeline, and scientists trying find innovative novel strategies target microbial enemies. Nature has remained a source inspiration for most developed used, immune molecules produced by innate defense systems, as first line defense, have been heralded next antibiotics. Most living...
This study reports the development of a class eco-friendly antifouling biocides based on cyclic dipeptide scaffold, 2,5-diketopiperazine (2,5-DKP). The lead compound cyclo(N-Bip-l-Arg-N-Bip-l-Arg) (1) was synthesized in gram amounts and used to assess compatibility with an ablation/hydration coating, efficacy against biofouling, biodegradation. Leaching 1 from coating into seawater assessed via rotating drum method, revealing relatively stable predictable leaching rates under dynamic shear...
Antimicrobial drug resistance is a looming health crisis facing us in the modern era, and new drugs are urgently needed to combat this growing problem. Synthetic mimics of antimicrobial peptides have recently emerged as promising class compounds for treatment persistent microbial infections. In current study, we investigate five cyclic N-alkylated amphiphilic 2,5-diketopiperazines against 15 different strains bacteria fungi, including drug-resistant clinical isolates. Several displayed...
Our study describes how regio- and stereochemistry influences the antifouling activity of naturally inspired 2,5-diketopiperazines.
Marine biofouling is a problem that plagues all maritime industries at vast economic and environmental cost. Previous current methods to inhibit have employed the use of toxic/highly persistent chemicals heavy metals, including tin, copper, zinc. These toxic are now coming under immense regulatory pressure, an eco-friendly alternative urgently required. Amphiphilic micropeptides recently been shown exhibit excellent broad-spectrum antifouling activity, with non-toxic mode action. The present...