A5077680420- Asthma and respiratory diseases
- Monoclonal and Polyclonal Antibodies Research
- Breast Implant and Reconstruction
- Peptidase Inhibition and Analysis
- Advanced Breast Cancer Therapies
- HER2/EGFR in Cancer Research
- Immune Cell Function and Interaction
- Breast Lesions and Carcinomas
- Neonatal Respiratory Health Research
- Immune Response and Inflammation
- Hepatocellular Carcinoma Treatment and Prognosis
- Breast Cancer Treatment Studies
- Yeasts and Rust Fungi Studies
- Economic and Financial Impacts of Cancer
- Cancer-related Molecular Pathways
- Reconstructive Surgery and Microvascular Techniques
- Statistical Methods in Clinical Trials
- Nerve Injury and Rehabilitation
- Chronic Lymphocytic Leukemia Research
- Plant Pathogens and Resistance
- Plant Pathogens and Fungal Diseases
- Epigenetics and DNA Methylation
- Neuroscience of respiration and sleep
- Neuroinflammation and Neurodegeneration Mechanisms
- Respiratory and Cough-Related Research
Oregon Health & Science University
2019-2023
Legacy Health
2016-2018
Mississippi State University
2018
The combination of everolimus (EVE) and exemestane (EXE) is approved for the treatment patients with metastatic hormone receptor-positive breast cancer (mHRBC) who progress on nonsteroidal aromatase inhibitor (NSAI) therapy. However, none enrolled in trial that led to this approval (BOLERO-2) had previously received CDK4/6 inhibitors (CDK4/6is), which have since become a frontline standard care mHRBC. As such, clinical benefit EVE plus EXE CDK4/6is remains unknown.Adult mHRBC at our...
1058 Background: The combination of everolimus (EVE) and exemestane (EXE) is approved as second line endocrine therapy for metastatic hormone receptor positive breast cancer (mHRBC) patients who progressed on non-steroidal aromatase inhibitor (NSAI) based the BOLERO-2 trial. However, none in received prior CDK4/6 inhibitors, which have since become standard care HRBC. As such, clinical benefit EVE + EXE mHRBC previously treated with inhibitors remains unknown. Methods: We reviewed ≥18yo...
Species richness and diversity of Phytophthora spp. (water molds) in urban riparian-forest ecosystems, which serve as primary drainage passageways for surface-water runoff, may be attributed to surrounding landscape management, associated vegetation, environmental conditions. These riparian areas, although generally small, are always flooded during wet seasons almost completely dry the hottest parts each year when there is limited precipitation. Little known about within these heavily...
Asthma susceptibility is influenced by environmental, genetic, and epigenetic factors. DNA methylation one form of modification that regulates gene expression both inherited modified environmental exposures throughout life. Prenatal development a particularly vulnerable time period during which exposure to maternal asthma increases risk in offspring. How affects offspring what the consequences differential are subsequent generations not fully known. In this study, we tested effects...
Docetaxel in combination with two HER2-directed therapies, trastuzumab and pertuzumab, is the current standard frontline therapy for patients metastatic HER2-positive breast cancer. Ado-trastuzumab (T-DM1), an antibody-drug conjugate of a cytotoxic microtubule-inhibitory agent, emtansine, approved that have progressed prior trastuzumab-based therapy. However, benefit T-DM1 previously treated pertuzumab cancer remains unclear.We identified thirty-three adults between March 2013 July 2018...
Toll-like receptor 7 (TLR7) is an innate immune that detects viral single-stranded RNA and triggers the production of proinflammatory cytokines type 1 interferons in cells. TLR7 agonists also modulate sensory nerve function by increasing neuronal excitability, although studies are conflicting whether neurons specifically express TLR7. This uncertainty has confounded development a mechanistic understanding nervous tissues.TLR7 expression was tested using situ hybridization with...
ABSTRACT Maternal asthma increases childhood risk through multiple mechanisms including epigenetic regulation of asthma-associated genes. DNA methylation is one form that both inherited and modified by environmental exposures throughout life. In this study, we tested whether grandmaternal house dust mite (HDM) allergen exposure altered airway physiology inflammation, as well in epithelium sensory neurons second-generation offspring. Grandmaternal induced a limited number changes offspring at...
Abstract Background: Docetaxel in combination with two HER2-directed therapies, trastuzumab and pertuzumab, is the current standard frontline therapy for patients metastatic HER2-positive breast cancer. Ado-trastuzumab (T-DM1), an antibody-drug conjugate of a cytotoxic microtubule-inhibitory agent, emtansine, approved that have progressed prior trastuzumab-based therapy. However, benefit T-DM1 previously treated pertuzumab cancer remains unclear. Methods: We identified thirty-three adults...