A5054678150- Complement system in diseases
- Chronic Lymphocytic Leukemia Research
- Monoclonal and Polyclonal Antibodies Research
- Biomedical and Engineering Education
- CAR-T cell therapy research
- Hormonal Regulation and Hypertension
- Nanowire Synthesis and Applications
- Problem and Project Based Learning
- Estrogen and related hormone effects
- Integrated Circuits and Semiconductor Failure Analysis
- Innovations in Medical Education
- Intravenous Infusion Technology and Safety
- Healthcare Technology and Patient Monitoring
- Antibiotics Pharmacokinetics and Efficacy
- Hypothalamic control of reproductive hormones
National Heart Lung and Blood Institute
2016-2025
National Institutes of Health
2016-2025
Memorial Sloan Kettering Cancer Center
2022
Cornell University
2022
The University of Texas Southwestern Medical Center
2014
Rice University
2011
B-cell maturation antigen (BCMA)-directed chimeric receptor (CAR) T-cell therapies have generated responses in patients with advanced myeloma, but relapses are common. G protein-coupled receptor, class C, group 5, member D (GPRC5D) has been identified as an immunotherapeutic target multiple myeloma. Preclinical studies shown the efficacy of GPRC5D-targeted CAR T cells, including activity a BCMA escape model.In this phase 1 dose-escalation study, we administered therapy (MCARH109) at four...
Hospitals in the developing world lack access to an affordable means of administering intravenous therapy at accuracy required for neonates. This paper presents design and performance a mechanical syringe pump delivering IV low-resource settings. Current available pumps are limited electronic disposable pumps. Commercially pumps, frequently used developed world, expensive, require highly trained technical personnel, rely on electricity source, so they unfeasible clinics. Disposable other...
Medicine is an area teeming with opportunities for innovation. However, medical education remains focused on the memorization of large volumes information rather than cultivation critical thinking skills. Students who enter aspirations service-learning or device development have no outlet these passions. For reasons, students at University Texas Southwestern Medical School created and been running a health innovations course called Innovating Healthcare Solutions (IHS) to instruct in design...
Abstract Treatment of lymphoid malignancies with anti-CD20 antibodies (mAbs) can be frustrated by the loss cell surface CD20 through trogocytosis, creating “escape variants” that are no longer sensitive to mAb. In patients chronic lymphocytic leukemia (CLL) treated mAb ofatumumab, we observed these escape variants carried covalently bound C3d complement fragments and opsonized CLL cells persisted for weeks in circulation. Therefore, hypothesized is a neoantigen could exploited re-target have...