A5067212030- Silk-based biomaterials and applications
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- 3D Printing in Biomedical Research
- Hydrogels: synthesis, properties, applications
- RNA Interference and Gene Delivery
- Bone Tissue Engineering Materials
- Congenital heart defects research
- Periodontal Regeneration and Treatments
- Silkworms and Sericulture Research
- Congenital Heart Disease Studies
- Corneal Surgery and Treatments
- Tendon Structure and Treatment
- Hemoglobin structure and function
- Biochemical and Structural Characterization
- Surfactants and Colloidal Systems
- Optical Imaging and Spectroscopy Techniques
- Wound Healing and Treatments
- Advanced Materials and Mechanics
- Surgical Sutures and Adhesives
- Advanced MRI Techniques and Applications
- Blood properties and coagulation
- Polysaccharides Composition and Applications
- Cardiomyopathy and Myosin Studies
- Characterization and Applications of Magnetic Nanoparticles
University of Florida
2020-2025
Tufts University
2014-2022
Medford Radiology Group
2017-2020
University of Massachusetts Amherst
2010-2013
Amherst College
2010
Engineering visible light crosslinked GelMA hydrogels with tunable physical properties.
Cardiac malformations and disease are the leading causes of death in United States live-born infants adults, respectively. In both these cases, a decrease number functional cardiomyocytes often results improper growth heart tissue, wound healing complications, poor tissue repair. The field cardiac engineering seeks to address concerns by developing patches created from variety biomaterial scaffolds be used surgical repair heart. These should fully degradable systems with tunable properties...
Abstract Terminal, or postprocessing, sterilization of composite biomaterials is crucial for their use in wound healing and tissue‐engineered devices. Recent research has focused on optimizing traditional biomaterial formulations to create better products commercial academic which incorporate hydrophobic compounds secondary gel networks. To a hydrogel clinical setting, terminal necessary ensure patient safety. Lyophilization, gamma‐irradiation, ethylene oxide treatment all have negative...
Heart failure is the leading cause of death in United States and rapidly becoming worldwide. While pharmacological treatments can reduce progression to heart following myocardial infarction, there still exists a need for new therapies that promote better healing postinjury more functional cardiac repair methods understand how changes tissue mechanical properties influence cell phenotype function injury. To address this need, we have optimized silk-based hydrogel platform containing...
Abstract Sponge‐like materials made from regenerated silk fibroin biopolymers are a tunable and advantageous platform for in vitro engineered tissue culture vivo regeneration. Anisotropic, three‐dimensional (3D) sponge‐like scaffolds can mimic the architecture of contractile muscle. Herein, we use solution isolated cocoons Bombyx mori silkworms to form aligned sponges via directional ice templating custom mold with slurry dry ethanol. Hydrated tensile mechanical properties these were...
Silk fibers are produced by a wide variety of insects. The silkworm
Abstract Perfluorocarbons (PFCs) are used in biomaterial formulations to increase oxygen (O 2 ) tension and create a homogeneous O environment three‐dimensional tissue constructs. It is unclear how PFCs affect mechanical transport properties of the scaffold, which critical for robustness, intracellular signaling, protein transport, overall device efficacy. In this study, we investigate composite alginate hydrogels containing perfluorooctyl bromide (PFOB) emulsion stabilized with Pluronic ®...
In this paper, we present a three-dimensional graphene foam made of few layers CVD grown as scaffold for growing cardiac cells and recording their electrical activity. Our results show that not only provides an excellent extra-cellular matrix (ECM) the culture such electrogenic but also enables its extracellular activity in-situ. Recording is possible due to graphene's conductivity. our on fabrication initial studies cell lines HL-1 real-time
Sponge-like biomaterials formed from silk fibroin are promising as degradable materials in clinical applications due to their controllable breakdown into simple amino acids or small peptides vivo . Silk fibroin, isolated Bombyx mori silkworm cocoons, can be used form sponge-like with a variety of tunable parameters including the elastic modulus, porosity and pore size, level nanocrystalline domains. These independently tuned during formulation resulting wide parameter space set final...
Donor organ shortages have prompted the development of alternative implantable human liver tissues for patients suffering from end-stage failure. Purified silk proteins provide desirable features generating tissues, including sustainable sourcing insects/arachnids, biocompatibility, tunable mechanical properties and degradation rates, low immunogenicity upon implantation. While different cell types were previously cultured weeks within silk-based scaffolds, it remains unclear whether such...
Oxygen therapeutics has a range of applications in transfusion medicine and disease treatment. Synthetic molecules all‐natural or semisynthetic hemoglobin‐based oxygen carriers (HBOCs) have seen success as potential circulating carriers. However, many early HBOC products stalled development due to side effects from excess hemoglobin the blood stream entering tissue. To overcome these issues, research focused on increasing molecular diameter by polymerizing encapsulating liposomal This work...