A5073992011- Vitamin D Research Studies
- Mesenchymal stem cell research
- Bone and Joint Diseases
- Rheumatoid Arthritis Research and Therapies
- T-cell and B-cell Immunology
- Macrophage Migration Inhibitory Factor
- Hematopoietic Stem Cell Transplantation
- Reproductive System and Pregnancy
- CAR-T cell therapy research
- Tryptophan and brain disorders
- Urticaria and Related Conditions
- Adrenal Hormones and Disorders
- Psoriasis: Treatment and Pathogenesis
- Autoimmune and Inflammatory Disorders Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chemokine receptors and signaling
- Vitamin C and Antioxidants Research
- Endometriosis Research and Treatment
- Inflammatory Myopathies and Dermatomyositis
- Bipolar Disorder and Treatment
- Osteoarthritis Treatment and Mechanisms
Torbat Heydarieh University of Medical Sciences
2019-2023
Mashhad University of Medical Sciences
2015-2020
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune arthropathy characterized by synovial hyperplasia leading to functional impairment. Although the exact cause of RA unknown, there evidence suggesting role T cell subtypes in pathogenesis RA. Conventional therapy some patients associated with mild or severe side effects, and resistance has been reported these types therapy. The therapeutic potential mesenchymal stem cells (MSCs) introduced them as novel choice for treatment...
Rheumatoid arthritis (RA) is an advanced autoimmune disease described by joint involvement. The special properties of mesenchymal stem cells (MSCs) introduced them as a potential therapeutic candidate for RA. In this study, single dose autologous MSCs isolated from bone marrow (autologous BM-MSCs, 1 × 106 per kg) was injected intravenously into 13 patients suffering refractory RA who were followed up within 12 months after the intervention to evaluate immunological elements. Our results...
The therapeutic and immunomodulatory potential of mesenchymal stem cells (MSCs) in rheumatoid arthritis (RA) has attracted considerable scientific attention recent decades. This study aimed to evaluate the expression genes encoding interleukin (IL)4 IL10, as well interferon-gamma (IFNG) transforming growth factor beta (TGFB1) refractory RA patients following intravenous injection autologous bone marrow-derived MSCs (BM-MSCs). was registered Iranian Registry Clinical Trials (IRCT)...
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting various organs. Decreased numbers of regulatory T-cells (Treg cells; CD4+CD25highFoxp3+) are associated with the pathogenesis SLE. A vitamin D deficiency was observed in many patients. In present study, peripheral blood mononuclear cells were isolated and cultured presence or absence D, total Tregs percentage analyzed by flow cytometry. addition, level expressions Foxp3, TGFβ, IL6 genes real-time-PCR. The results...
The synovial- lining cells have been involved with rheumatoid arthritis (RA) through the secretion of various cytokines and chemokines. Increased levels these chemokines are seen first in synovial subsequently bloodstream RA patients. circulating CXCL8, CXCL12, CXCL13 higher patients than healthy subjects, causing migration immune to joints, which is associated increased joint destruction. We aimed evaluate effects autologous mesenchymal stem intravenous administration on plasma CXCL12 at 1,...
Background: Bipolar disorder (BD) is one of the most important psychiatric disorders in world. There evidence suggesting role inflammatory mediators such as chemokines etiology BD. The objective current study was to evaluate gene expression CCL2, CCL3, and CXCL8 patients with BD compare them healthy controls. Materials Methods: A total 48 confirmed controls enrolled this study. All were recruited from April August 2016 at Ibn-Sina Psychiatric Hospital, Mashhad University Medical Sciences,...
Rheumatoid arthritis (RA) is the most prevalent autoimmune disease, in which CCL2 and CCL5 are critically involved. The objective was to evaluate therapeutic effects of bone marrow-derived mesenchymal stem cells (MSCs) on foregoing chemokines RA patients.Thirteen patients were evaluated terms clinical manifestations, paraclinical factors, gene expression, plasma levels prior treatment 1 6 months after intervention. Real-time-polymerase chain reaction enzyme-linked immunosorbent assay...
Event Abstract Back to Effects of Vit D on Th17 cells and related cytokines in lupus erythematosus patients Hadi Reihani1*, Maryam Rastin1, Sahebari2, Mahmoud Mahmoudi1, Mohsen Ghoryani1, Nafiseh Abdollahi2, Sadat Tabasi1, Shahrzad Zamani Taghizadeh Rabe1, Fahimeh Lavi Arab1 Fatemeh Faraji1 1 Immunology Research Center, BuAli Institute, Faculty Medicine, Mashhad University Medical Sciencses, Mashhad, Iran 2 Rheumatology Ghaem Hospital,Mashhad Introduction: Systemic is a multisystem...
Event Abstract Back to Assessment of vitamin D effects in lupus- like syndrome induced mice model Fahimeh Lavi Arab1*, Fatemeh Faraji1, Maryam Rastin1, Mahmoud Mahmoudi1, Dariush Haghmorad1, Reza Nosratabadi1, Shahrzad Zamani Taghizadeh Rabe1, Nafise Tabasi1, Hadi Reihani Elmeh Jough1 and Mohsen Ghoryani1 1 Immunology Research center, BuAli Institute, Faculty Medicine, Mashhad University Medical Sciences, Iran Introduction:Systemic lupus erythematosus(SLE) is an autoimmune disease...
Event Abstract Back to Effects of Vitamin D on Regulatory T cells in lupus patients Mohsen Ghoryani1*, Maryam Rastin1, Sahebari2, Mahmoud Mahmoudi1, Hadi Reihani1, Nafiseh Abdollahi2, Nafisehsadat Tabasi1, Shahrzad Zamani1, Fahimeh Lavi Arab1 and Fatemeh Faraji1 1 Immunology Research Center, BuAli Institute, Faculty Medicine, Mashhad University Medical Sciencses, Mashhad, Iran, Islamic Republic of, Immunology, Iran 2 Rheumatology Ghaem Hospital,Mashhad Rheumatology, Introduction: Systemic...
Event Abstract Back to 1,25 Dihydroxy vitamin D modulatory effects on Patients with systemic lupus erythematosus Maryam Rastin1*, Mahmoud Mahmoudi1, Sahebari2, Nafiseh Tabasi1, Shahrzad Zamani1, Mohsen Ghoryani1 and Hadi Reihani1 1 Immunology Research Center, BuAli Institute, Mashhad University of Medical Sciences, Iran 2 Internal Medicine, Rheumatology Objectives: Systemic is an autoimmune disease that complicated by autoantibody mediated organ involvements. In SLE immune tolerance...