Abstract Objective The antimalarial medication hydroxychloroquine has been proposed as a thromboprotective agent in systemic lupus erythematosus (SLE), but studies thus far have limited by the possibility of confounding indication. This study was conducted to assess whether exposure drugs is associated with decrease thrombovascular events (TEs) patients SLE. Methods designed nested case–control embedded an inception cohort SLE, which allowed adjustments for possible calendar year, duration...

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune arthropathy characterized by synovial hyperplasia leading to functional impairment. Although the exact cause of RA unknown, there evidence suggesting role T cell subtypes in pathogenesis RA. Conventional therapy some patients associated with mild or severe side effects, and resistance has been reported these types therapy. The therapeutic potential mesenchymal stem cells (MSCs) introduced them as novel choice for treatment...

Rheumatoid arthritis (RA) is an advanced autoimmune disease described by joint involvement. The special properties of mesenchymal stem cells (MSCs) introduced them as a potential therapeutic candidate for RA. In this study, single dose autologous MSCs isolated from bone marrow (autologous BM-MSCs, 1 × 106 per kg) was injected intravenously into 13 patients suffering refractory RA who were followed up within 12 months after the intervention to evaluate immunological elements. Our results...

Thrombosis has been reported in 7.2–12% of persons with systemic lupus erythematosus (SLE) (1-3). In a 10-year prospective cohort study patients SLE, the most frequent causes death were active SLE (26.5%), thrombosis and infection (25%), dominating second 5-year period followup (4). The incidence rates after diagnosis remain unknown. We report yearly arterial venous an inception SLE. studied from University Toronto Lupus Database; was defined as either fulfillment at least 4 1982 American...

Background: Kidney involvement is prevalent in systemic lupus erythematosus (SLE) and the leading cause of disability death. Colony-stimulating factor-1 (CSF-1) may be involved development nephritis (LN). This study aimed to evaluate serum CSF-1 levels SLE patients with without proteinuria its correlation value proteinuria. Methods: A total 75 subjects including 25 newly diagnosed cases renal evidence, new biopsy-proven LN, also, healthy controls were included study. Serum level was measured...

Osteoarthritis (OA) is the major cause of joint pain and disability. This research was planned to examine effects Krocina™, aherbal medicine made crocin, an ingredient saffron, in patients with OA. Forty suffering from OA were enrolled our study randomly divided into two groups, receiving Krocina™ placebo, clinical trial continued for four months.Peripheral blood taken all percentage ofvarious subsets T cells addition levels forkhead box protein P3 (FOXP3) interleukin (IL)-17 measured by...

Osteoarthritis is the most common disease in group of joint diseases, and its incidence directly related to aging. Given anti-inflammatory effects curcumin as an active ingredient turmeric, we aimed investigate this compound a new nanomicelle formula named SinaCurcumin® on expression microRNAs (miRNAs) involved immune responses patients with osteoarthritis.We divided 30 osteoarthritis into two groups namely, nano curcumin-receiving (15 patients) placebo-receiving studied them for 3 months....

The therapeutic and immunomodulatory potential of mesenchymal stem cells (MSCs) in rheumatoid arthritis (RA) has attracted considerable scientific attention recent decades. This study aimed to evaluate the expression genes encoding interleukin (IL)4 IL10, as well interferon-gamma (IFNG) transforming growth factor beta (TGFB1) refractory RA patients following intravenous injection autologous bone marrow-derived MSCs (BM-MSCs). was registered Iranian Registry Clinical Trials (IRCT)...

To determine clinical features of different histopathological presentations in patients with lupus nephritis (LN).Clinical and pathological 71 biopsy-proven LN were analyzed a cross-sectional study during 2005-2011.Sixty-five women (91.5%) six men (8.5%) studied. The mean Activity Index (AI) Chronicity (CI) 6.2 ± 3.1 1.7 1.5, respectively. most common histopathologic presentation kidneys was class IV (52.1%). Patients more advanced International Society Nephrology the Renal Pathology...

Background: Rheumatoid arthritis (RA) is a chronic inflammatory joint disorder with unknown etiology.Atorvastatin lipid-lowering agent that affects the processes.Objective: This study aimed to determine anti-inflammatory effects of atorvastatin on Disease Activity Index and high-density lipoprotein (HDL) concentrations in RA patients.Methods: clinical trial was performed 38 patients, who were referred Imam Reza Ghaem Medical Centers Mashhad, Iran between 2013 2014.Patients divided into two...

Platelet-rich plasma (PRP), an autologous source of growth factors, and hyaluronic acid (HA) are among the minimally invasive treatments for knee osteoarthritis (OA). This trial was designed to compare effectiveness intra-articular injection PRP with HA (as one standard treatments) on mild moderate OA.In this phase I open-label clinical trial, 10 patients underwent others received injection. At baseline (pre-injection) visit 1, 3, 6, 12 months post-injection, assessments were performed using...

The synovial- lining cells have been involved with rheumatoid arthritis (RA) through the secretion of various cytokines and chemokines. Increased levels these chemokines are seen first in synovial subsequently bloodstream RA patients. circulating CXCL8, CXCL12, CXCL13 higher patients than healthy subjects, causing migration immune to joints, which is associated increased joint destruction. We aimed evaluate effects autologous mesenchymal stem intravenous administration on plasma CXCL12 at 1,...

Background:Methotrexate (MTX) is one of the most commonly used disease-modifying antirheumatic drugs in treatment rheumatoid arthritis (RA) which can be associated with toxic effects on different organs. This study was designed to investigate hepatotoxic RA patients treated MTX. Methods: In this cross-sectional observational study, who received standard dose regimen methotrexate (7.5-15 mg/week) for a minimum 3 months were included. Liver function parameters including serum alanine...

Systemic sclerosis (SSc) is an autoimmune, connective tissue disorder of unknown etiology which causes vasculopathy and fibrosis. Raynaud's phenomenon (RP) a common complication SSc, leads to ischemia gangrenes. Treatment RP clinical problem often remains insufficient.This study aimed evaluate the therapeutic efficacy local injections botulinum toxin type A (BTX-A) in improving symptoms secondary scleroderma.This parallel single-blinded, placebo-controlled trial enrolled 29 patients with...

This study aims to determine the relationship between severity of sarcoidosis and serum B-cell activating factor (BAFF) concentrations.This cross-sectional was conducted December 2015 March 2018 on 55 patients with (16 males, 39 females; mean age, 39.9; range 25 60 years) 28 healthy subjects (7 20 39; years). The were divided into active chronic acute groups. diagnosis based clinical, radiological, pathologic findings. Also, disease level angiotensin-converting enzyme, skin, eye, lung...