Abstract Background Previous research has shown that Ramadan fasting beneficial effects on cardiovascular risk factors, however there are controversies. In the present study, effect of factors been investigated. Method This is a prospective observational study was carried out in group patients with at least one factor (including history documented previous either coronary artery disease (CAD), metabolic syndrome or cerebro-vascular past 10 y). Eighty two volunteers including 38 male and 44...

Obesity is a disorder often accompanied by heightened state of systemic inflammation and immunoactivation. The present randomized crossover trial aimed to investigate the efficacy curcumin, bioactive polyphenol with established anti-inflammatory immunomodulatory effects, on serum levels panel cytokines mediators in obese individuals.Thirty individuals were receive curcumin at daily dose 1 g or matched placebo for 4 weeks. Following 2-week wash-out period, each group was assigned alternate...

Curcuminoids have potentially important functional qualities including anti‐inflammatory and antioxidant properties. In this randomized double‐blind placebo‐controlled cross‐over trial, the effects of a curcuminoid supplement on serum pro‐oxidant–antioxidant balance (PAB) antibody titres to Hsp27 (anti‐Hsp27) oxLDL (anti‐oxLDL) were investigated. Thirty obese individuals receive either curcuminoids (1 g/day) or placebo for period 30 days. After wash‐out 2 weeks, subjects crossed over...

A randomized controlled clinical trial in 196 obese subjects was performed to examine the effectiveness of body acupuncture on weight loss, lipid profile and immunogenic inflammatory markers. Subjects received authentic (cases) or sham (controls) for 6 weeks combination with a low-calorie diet. In following weeks, they diet alone. were assessed at beginning, 12 later. Heat shock protein (Hsps)-27, 60, 65, 70 antibody titers high sensitivity C-reactive (hs-CRP) levels also assessed....

Background : One possible factor contributing to low back pain is hip range of motion (ROM). However, there inconstancy in published studies, which may be due the heterogeneity patients. Therefore, present study focuses on relationship between ROM and lower lumbar disc herniation (LLDH). Method A cross-sectional involved 52 participants 18 65 years old. Two digital inclinometers were utilized measure joints all participants. For each outcome, 2 measurements conducted, mean was for analysis....

Rheumatoid arthritis (RA) is the most common form of autoimmune arthritis. Increased prevalence metabolic syndrome (MetS) in RA may occur secondary to specific drug treatment and reduced physical activity associated with this condition. However, some recent studies suggest contradictory theories about association MetS. This study was designed evaluate frequency MetS patients relationship between disease body mass index (BMI). The conducted on 120 431 age- sex-matched apparently healthy...

Background Migraine is one of the most common types headache, with significant socioeconomic effects. Prophylactic drugs are used to prevent migraine headaches but unpromising. Objective To assess effects adding acupuncture conventional prophylaxis. Methods One hundred patients (41 male, 59 female), in whom prophylactic had not produced a fall at least 50% number attacks, entered study. The were randomised into two groups, sham and true acupuncture. both groups continued their treatment...

Antibody titers to several heat shock proteins (anti-Hsps) have been reported be associated with the severity and progression of cardiovascular disease. However, there are little data regarding anti-Hsp27 in patients coronary artery disease (CAD). A total 400 suspected CAD were recruited. Based on results angiography, these classified into CAD(+) (n = 300) CAD(-) 100) groups defined as ≥50% <50% stenosis any major artery, respectively. Eighty-three healthy subjects also recruited control...

Esophageal cancer is among the most common gastrointestinal cancers for which main treatment surgery. This study was undertaken to analyze results of Botox injection in preventing gastric stasis these patients.60 patients with esophageal middle and lower third parts were included our between 2010 2011, randomly divided into two groups. In group A, 30 underwent pyloroplasty, B, botulinum toxin pyloric sphincter muscle used patients.The mean age 61 ± 10.7 years male/female ratio 33:27. Isotope...

The purpose of this prospective, randomized, double-blind, placebo-controlled study was to determine the effect preoperative oral administration ibuprofen or dexamethasone on success rate inferior alveolar nerve block (IANB) in patients with symptomatic irreversible pulpitis.Seventy-eight pulpitis were randomly divided into 3 groups (26 per group) and given one following at 1 hr prior performing local anesthesia: a placebo; 400 mg ibuprofen; 4 dexamethasone.Each patient recorded their pain...

Abstract Background Nutrition support plays a pivotal role in improving the clinical outcomes of patients admitted to intensive care unit (ICU). However, there are controversies regarding optimal amount energy for reduction morbidity and mortality neurosurgical at ICU. Methods This randomized trial was conducted on 560 who were trauma, stroke, neurosurgery ICUs, 68 enrolled based inclusion criteria. In total, data 58 analyzed. full‐energy group, enteral feeding started 75% their daily...

BACKGROUND: Coronary artery disease (CAD) is the most common type of cardiovascular . Increasing expression and activity matrix metalloproteinases (MMPs) facilitates vascular remodeling complications. Curcumin (the active ingredient turmeric) a potent natural anti-inflammatory agent, with protective effects. The present study was clinical trial for investigating effects curcumin on gene MMP-2 MMP-9 in patients CAD. METHODS: In this study, 70 CAD (with 40%-50% stenosis) were randomly divided...

Oral-facial clefts including cleft lip and palate are the most common congenital malformations of head neck. Environmental factors such as maternal hormonal disorders, use psychiatric medications, vitamin folic acid deficiency, hypoxia, cigarette smoking obesity overweight can affect incidence these disorders. In Iran, one associated problems is a lack accurate statistics regarding present status patients, which cause disturbance in health programmes Ministry Health Medical Education. The...

BackgroundThere is controversial evidence about the effect of cerebellar low-frequency stimulation in patients with essential tremor (ET).ObjectivesIn this study we assessed safety and effectiveness 1 Hz (low-frequency) repetitive transcranial magnetic (rTMS) on severity a sham-controlled crossover trial.MethodsA total 23 assigned into two groups to receive either sham (n = 10) or rTMS 13) treatment, crossing over after two-month washout period. Intervention consisted 900 pulses at 90%...

The metabolic syndrome (MetS) is characterized by constellation of clinical and biochemical features that increase the risk cardiovascular disease. Neuropeptide Y (NPY) a neurotransmitter enhances development obesity other aspects MetS. We determined association between NPY Leu7Pro polymorphism MetS in Iranian patients with coronary artery disease (CAD). A total 550 CAD including individuals (n = 184) without 366) were genotyped polymerase chain reaction–restriction fragment length...

It has been reported that obesity is associated with higher levels of oxidative stress. We aimed to evaluate the hypothesis pro-oxidant antioxidant balance (PAB) values could be affected by adiposity and assess association between PAB indices obesity.Subjects (n = 733) were recruited tlen divided into 3 groups normal-weight (BMI < 25, n 207), overweight (25 BMI 30, 375), obese > 151). measured in all participants.There was a significant weight when correlation determined for subjects (p...

Non-alcoholic fatty liver disease (NAFLD) is becoming increasingly prevalent worldwide, and cardiovascular diseases are the most common cause of death in NAFLD patients. The present study aimed to evaluate possible relationship between presence severity coronary artery (CAD).A cross-sectional was conducted on 296 patients (122 men 174 women, with mean age 54.10 ± 9.33 years) referred catheterization laboratory Imam Reza Hospital affiliated Mashhad University Medical Sciences, Mashhad, Iran,...

Old world cutaneous leishmaniasis (CL) is known as a self-healing parasitic infection. Host immunity has fundamental role in the course of this This study was designed to investigate relationship between nutritional status and vitamin A intake with clinical CL.Overall, 250 patients CL attending dermatology clinic Imam Reza Hospital Mashhad, Iran, were enrolled from Apr 2011 Aug 2012. For data gathering, semi-quantitative 302-item food frequency questionnaire utilized. They received routine...

Background:Methotrexate (MTX) is one of the most commonly used disease-modifying antirheumatic drugs in treatment rheumatoid arthritis (RA) which can be associated with toxic effects on different organs. This study was designed to investigate hepatotoxic RA patients treated MTX. Methods: In this cross-sectional observational study, who received standard dose regimen methotrexate (7.5-15 mg/week) for a minimum 3 months were included. Liver function parameters including serum alanine...