A5057723531- Epigenetics and DNA Methylation
- Drug Transport and Resistance Mechanisms
- Cancer-related gene regulation
- Natural product bioactivities and synthesis
- Phytochemical compounds biological activities
- Cancer-related Molecular Pathways
- Plant chemical constituents analysis
- Immunotherapy and Immune Responses
- Cancer Cells and Metastasis
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Neuropeptides and Animal Physiology
- Biochemical effects in animals
- Estrogen and related hormone effects
- Marine Sponges and Natural Products
- Heat shock proteins research
- Glycosylation and Glycoproteins Research
- Histone Deacetylase Inhibitors Research
- Studies on Chitinases and Chitosanases
- Genomics, phytochemicals, and oxidative stress
- Bioactive Compounds and Antitumor Agents
- Ubiquitin and proteasome pathways
- Apelin-related biomedical research
- Wnt/β-catenin signaling in development and cancer
Mashhad University of Medical Sciences
2015-2024
Biotechnology Research Center
2015-2024
Yazd University
2014
Islamic Azad University, Mashhad
2011
Obesity is a disorder often accompanied by heightened state of systemic inflammation and immunoactivation. The present randomized crossover trial aimed to investigate the efficacy curcumin, bioactive polyphenol with established anti-inflammatory immunomodulatory effects, on serum levels panel cytokines mediators in obese individuals.Thirty individuals were receive curcumin at daily dose 1 g or matched placebo for 4 weeks. Following 2-week wash-out period, each group was assigned alternate...
Wound healing is a complicated process that contains number of overlapping and consecutive phases, disruption in each which can cause chronic nonhealing wounds. In the current study, we investigated effects exosomes as paracrine factors released from menstrual blood-derived mesenchymal stem cells (MenSCs) on wound-healing diabetic mice. The were isolated MenSCs conditioned media using ultracentrifugation characterized by scanning electron microscope western blotting assay. A full thickness...
Auraptene, a natural citrus coumarin, found in plants of Rutaceae and Apiaceae families. In this study, we investigated the effects auraptene on tumor migration, invasion matrix metalloproteinase (MMP)-2 -9 enzymes activity.The viability A2780 Hela cell lines was evaluated by MTT assay. Wound healing migration assay Boyden chamber were determined effect invasion, respectively. MMP-2 MMP-9 activities analyzed gelatin zymography assay.Auraptene reduced viability. The results showed that...
Tamoxifen is a standard anti‐hormone treatment in estrogen receptor positive breast carcinoma patients. Unfortunately, about 50% of patients relapse during treatment. Promoter hypermethylation contributes to the epigenetic modulation tamoxifen resistance‐related genes. To evaluate contribution DNMTs expression and their promoter methylation as diagnostic biomarkers development malignancy resistance, present study was designed 107 tumors normal tissues were recruited. Methylation‐specific...
Abstract Background The vascular endothelial growth factor receptor-2 (VEGFR-2) plays an important role in melanoma development and progression. Peptide vaccines have shown great potential cancer immunotherapy by targeting VEGFR-2 as a tumor-associated antigen boosting the immune response against both tumor cells cells. Despite this, low efficiency of peptide has resulted moderate therapeutic results majority studies. Enhancing delivery using nanoliposomes is strategy for improving efficacy...
Beneficial effects of glucosamine in spatial learning and memory impairment induced by scopolamine has been evaluated rats using Morris water maze. Male Wistar were randomly divided into control, plus groups. All injections given 5 consecutive days 30 min after each injection, the tested maze test. Escape latency path length to reach hidden platform subjected analysis variance [ANOVA]. The treated with showed increased escape compared control group (P < 0.001). Both traveled animals (1 2...
The antigenotoxic activity of glucosamine (GlcN) and N-acetylglucosamine (GlcNAc) in human peripheral lymphocytes exposed to oxidative stress was investigated. Human were treated with different concentrations these aminosugars (0, 2.5, 5, 10, 20 40 mM) 25 µM H2O2 simultaneously evaluated by single cell gel electrophoresis technique (Comet assay). cells analyzed using "TriTek Cometscore version 1.5" software the data presented as % DNA tail. Both GlcN GlcNAc at examined (2.5, did not reveal...
Obesity is a major risk factor of chronic-diseases, including cardiovascular-diseases (CVD). Increasing evidence showing the association heat-shock protein (HSP) with type-2 diabetes and CVD; however, there little data on relationship between genetic-polymorphisms HSP70-2 obesity.The present study has investigated 1267HSP70-2 genetic polymorphism obesity in an Iranian population 317 subjects.Anthropometric parameters biochemical measurements were measured all samples, while genotypes...
Background: Well-documented studies reported several pharmacological properties for crocin, the active compound of Crocus sativus, such as its antitumor, radical scavenging, antidepressant, and memory-enhancing effects. Objectives: We aimed to evaluate possible cytotoxic activity crocin on B lymphocytes in human myeloma (U266 cell line) after 24- 48-hour treatment. Materials Methods: For this purpose, viability was determined by colorimetric MTT assay death pattern evaluated using Annexin...
Background and aims: There have been few epidemiological studies that investigated genetic susceptibility to cardiovascular risk associated with the prevalence of metabolic syndrome (MetS). Neuropeptide Y (NPY) is a strong candidate gene for coronary artery disease (CAD). Therefore, aim this study was investigate association between NPY rs16147 polymorphism presence MetS in well defined group Iranian subjects angiographically-defined CAD.