A5085106503- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Rheumatoid Arthritis Research and Therapies
- Sarcoidosis and Beryllium Toxicity Research
- Pregnancy and Medication Impact
- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Viral Infections and Immunology Research
- Inflammasome and immune disorders
- Autoimmune and Inflammatory Disorders Research
- Eosinophilic Esophagitis
- Hepatitis C virus research
- Systemic Sclerosis and Related Diseases
German Rheumatism Research Centre
2020-2024
Charité - Universitätsmedizin Berlin
2024
Objectives To investigate the impact of disease activity and treatment with disease-modifying antirheumatic drugs (DMARDs) on all-cause mortality in patients rheumatoid arthritis prevalent interstitial lung (RA-ILD). Methods Patients RA-ILD were selected from biologics register Rheumatoid Arthritis: Observation Biologic Therapy (RABBIT). Using time-varying Cox regression, association between clinical measures was investigated. The DMARDs analysed by (1) regression considering cumulative...
In pharmacoepidemiology, robust data are needed to judge the impact of drug treatment on pregnancy, pregnancy outcomes and breast-fed infants. As pregnant breastfeeding women usually excluded from randomised clinical trials, observational studies required. One those sources registers specifically developed focus certain diseases or disease groups. The German Rhekiss register investigates pregnancies in with chronic inflammatory rheumatic (IRD). is a nationwide, multicentre, longitudinal...
Abstract Background To investigate the association between development of incident interstitial lung disease (ILD) in patients with rheumatoid arthritis (RA) and activity RA its various components, especially C-reactive protein (CRP) erythrocyte sedimentation rate (ESR). Methods We analysed data from patients, observed German biologics register RABBIT 2001 2021. In a nested case-control study, reported ILD diagnosis during follow-up were matched 1:5 to without ILD. Matching criteria sex,...
Background Ten percent of patients with prevalent rheumatoid arthritis (RA) develop an interstitial lung disease (ILD), which is associated higher mortality (1). A previous study identified high/moderate activity, but not CRP, as a risk factor for RA-ILD (2). Objectives To analyse whether systemic inflammation (CRP and ESR) and/or activity measured composite score (DAS28-ESR) are the occurrence ILD in RA. Methods Data from RA observed biologics register RABBIT until 10/2020 were included....
<h3>Background</h3> Heart failure (HF) is a common co-morbidity of rheumatoid arthritis (RA) with high mortality risk [1]. In the general population, significant sex-related differences in HF including aetiology, pathophysiological mechanisms and age are observed, emphasizing importance to stratify analyses by sex [2] there increasing evidence that rates females lower, which cannot be explained comorbidities, characteristics or medical treatment [3]. <h3>Objectives</h3> To investigate...
<h3>Background</h3> Interstitial lung disease (ILD) is one of the most common extra-articular manifestations rheumatoid arthritis (RA) with a high mortality risk. Only few studies examined association between RA treatment and in patients RA-ILD, these do not include all available DMARDs tend to be poor quality [1]. <h3>Objectives</h3> To investigate impact on all-cause RA-ILD taking inflammation, traditional risk factors comorbidities into account. <h3>Methods</h3> enrolled observed...
Background: There is little robust evidence on the course of pregnancy and its outcomes in women with psoriatic arthritis (PsA) which recommendations for management these patients could be based. Objectives: To review available data disease activity during adverse PsA. Methods: Systematic literature search within databases Pubmed Embase using keywords ‘psoriatic arthritis’ ‘pregnan*/ obstetr*/ matern*/ gestation*/ deliver*/ abortion*/ reproduct*/ birth/ parity’. All full text articles...
Background: Adults with rheumatoid arthritis (RA) have an increased risk of falling. Previous studies on causes falls neither sufficiently nor adequately considered the effects bDMARDs. In addition, a analysis individual substances has been lacking until now. Objectives: To analyze fall under exposure to TNFi’s, abatacept (ABA), rituximab (RTX) and tocilizumab (TOC) in comparison csDMARDs taking co-medication other factors such as disease activity, comorbidities biological risks into...