Abstract An effective and inexpensive organocatalyst tetrabutylammonium fluoride (TBAF) was developed for the reductive functionalization of CO 2 with amines to selectively afford formamides or methylamines by employing hydrosilanes. Hydrosilanes different substituents show discriminatory reducing activity. Thus, formation further reduction products, that is, could be controlled elegantly tuning hydrosilane types. Formamides were obtained exclusively under an atmospheric pressure...

A green and highly efficient method for the regioselective synthesis of imidazo[1,2-a]pyridine derivatives has been developed by annulation heterocyclic ketene aminals (HKAs) β-oxodithioesters (ODEs) as building blocks with aldehydes under solvent-free conditions using Et3N catalyst. The present shows fascinating properties such high regioselectivity, concise one-pot methodology, short reaction times, easy purification avoids use transition metals. This methodology provides an alternative...

Unprecedented imidazo[1,2-a]thiochromeno[3,2-e]pyridines have been synthesized via a three-component cascade reaction under solvent-free conditions. This one-pot transformation involving multiple steps and not requiring the use of transition metal catalysts constructs three new C–C bonds, two C–N one C–S bond, rings with all reactants efficiently utilized.

Electrochemical membrane filtration has proven to be successful for microbial removal and separation from water. In addition, fouling could mitigated by electrochemical reactions electrostatic repulsion on a reactive surface. This study assessed the performances characteristics of electrochemically ceramic membranes (a Magneli phase suboxide TiO2) when filtering algal suspension under different dc currents achieve anodic or cathodic polarization. The critical flux results indicate that...

We report the palladium-catalyzed double-decarbonylative synthesis of aryl thioethers by an exchange reaction between amides and thioesters. In this method, serve as donors thioesters are sulfide donors, enabling valuable sulfides. The use Pd/Xantphos without any additives has been identified catalytic system promoting C(O)-N/C(O)-S cleavages. method is amenable to a wide variety

Decarbonylative synthesis of thioethers from thioesters proceeds in the presence a catalytic amount [Rh(cod)Cl]2 (2 mol %). The protocol represents first Rh-catalyzed decarbonylative thioetherification to yield valuable thioethers. Notable features include absence phosphine ligands, inorganic bases, and other additives excellent group tolerance aryl chlorides bromides that are problematic using metals promote decarbonylation. Gram scale synthesis, late-stage pharmaceutical derivatization,...

We report a general method for direct decarbonylative thioetherification of carboxylic acids using air- and moisture-stable nickel precatalysts. In this approach, ubiquitous are directly used as aryl electrophiles common thiols serve sulfide donors.

We report a general and practical palladium-catalyzed intramolecular decarbonylative coupling of thioesters <italic>via</italic> C–S bond cleavage, decarbonylation reformation.

We report conversion of esters to thioesters <italic>via</italic> selective C–O bond cleavage/weak C–S formation under transition-metal-free conditions.

The novel target products were synthesized in the formation of a triazine ring from berberine, magnolol, and metformin catalyzed by sodium methylate. structures 1-3 firstly confirmed extensive spectroscopic analyses single-crystal X-ray diffraction. crystal product 2 intermediate 7b reported for first time. All evaluated their anti-inflammatory antidiabetic activities against INS-1 RAW264.1 cells vitro all showed excellent effects anti-insulin resistance effects. Our studies indicated that...

We report the rhodium-catalyzed base-free decarbonylative borylation of twisted amides. The synthesis versatile arylboronate esters from aryl amides is achieved via rhodium(I) catalysis and highly selective N–C(O) insertion. method notable for a very practical, additive-free Rh(I) catalyst system. shows broad functional group tolerance excellent substrate scope, including site-selective borylation/Heck cross-coupling divergent N–C/C–Br cleavage late-stage pharmaceutical borylation.

This work reports on a novel and convenient fluorescent assay for four quinolones including nalidixic acid, cinoxacin, ciprofloxacin moxifloxacin, with Cu²⁺-triggered quinolone-inhibited oxidation of <italic>o</italic>-phenylenediamine.

Based on the principle of molecular splicing and theory traditional Chinese medicine pairs, a new multi-active compound (HM475) was synthesized by connecting metformin with honokiol, its structure characterized, which not only reduced toxicity raw materials, but also maintained original activity, had certain significance in research innovation. At same time, quality control preliminary activity evaluation were carried out, effect HM475 neuroinflammation further explored, provided idea for...

A practical procedure for the addition of arylboronic acids to aromatic aldehydes has been developed in presence NiCl2(PPh3)2/1,3-bis-(2,6-diisopropylphenyl)imidazolium chloride (IPr·HCl) system with good yield. Generally, electron-rich and -neutral aryl showed excellent reactivity provided desired products high yields. This will provide new way synthesis diarylmethanols.

Diels-Alder reactions between cyclopentadiene analogs and p-benzoquinone were explored in water yielded 83-97% product, higher than the results reported with a catalyst or cetrimonium bromide (CTAB) micelles. The novel adduct 10 was synthesized further used to synthesize bi-cage hydrocarbon 4,4'-spirobi[pentacyclo[5.4.0.02,6.03,10.05,9]undecane], which has high density (1.2663 g cm-3) volumetric heat of combustion (53.353 MJ L-1). Four compounds using this method starting from...

N-1-Alkyl-2-unsubstituted benzimidazoles were directly synthesized by intermolecular coupling of formimidamides with benzylamines; the syntheses catalyzed Pd(OAc)2 in one pot, giving rise to moderate good yields. Aromatic formamidines various substituents as starting materials could be readily prepared from reactions corresponding anilines and N,N-dimethylformamide dimethyl acetal high