A5067852154- Genetic Associations and Epidemiology
- Bioinformatics and Genomic Networks
- Genomics and Rare Diseases
- Genetics and Neurodevelopmental Disorders
- Schizophrenia research and treatment
- Child and Adolescent Psychosocial and Emotional Development
- Genomic variations and chromosomal abnormalities
- Mental Health Research Topics
- Adolescent and Pediatric Healthcare
- BRCA gene mutations in cancer
- Bipolar Disorder and Treatment
- Law, logistics, and international trade
- Tryptophan and brain disorders
- Health, Environment, Cognitive Aging
- Genetics, Bioinformatics, and Biomedical Research
- European and International Contract Law
- Mental Health and Psychiatry
- Liver Disease Diagnosis and Treatment
- European and International Law Studies
- Genetic Mapping and Diversity in Plants and Animals
- Technology and Human Factors in Education and Health
Cardiff University
2020-2025
University of Bristol
2020-2025
Addenbrooke's Hospital
2020
University College London
2020
Royal College of Surgeons in Ireland
2020
University of Cambridge
2020
Trinity College Dublin
2018-2019
University of Edinburgh
2017-2018
Institute of Genetics and Cancer
2017
Graduate Institute of International and Development Studies
2016
The authors investigated the incidence, course, and outcome of psychotic experiences from childhood through early adulthood in general population examined prediction disorder.This was a population-based cohort study using semistructured Psychosis-Like Symptoms Interview at ages 12, 18, 24 (N=7,900 with any data). Incidence rates were estimated flexible parametric modeling, positive predictive values (PPVs), sensitivity, specificity, area under curve for prediction.The incidence rate...
A recent development in the genetic architecture of schizophrenia suggested that an omnigenic model may underlie risk for this disorder. The aim our study was to use polygenic profile scoring quantitatively assess whether a number experimentally derived sets would contribute disorder above and beyond effect. Using PGC2 secondary analysis case-control cohort (N = 29,125 cases 34,836 controls), robust signal observed from gene based on TCF4, FMR1, upregulation MIR137 downregulation CHD8....
Abstract Background Individuals with borderline intellectual functioning and disabilities (intellectual impairment) may be at increased risk of psychosis. However, studies have been limited by small selected samples. Moreover, the role early life trauma, a key factor for psychosis, in associations is unknown. Methods Using data from Avon Longitudinal Study Parents Children (ALSPAC) birth cohort, we investigated between impairment, psychotic disorders, experiences, assessed mediating trauma...
Impaired cognition in schizophrenia is associated with worse functional outcomes. While genetic factors are known to contribute variation schizophrenia, few rare coding variants strong effects have been identified, and the relative from de novo, inherited non-transmitted alleles unknown. We used array exome sequencing data 656 proband-parent trios examine contribution of common school performance, by implication cognitive function, schizophrenia. Parental transmission contributing higher...
Background Psychotic experiences are reported by 5–10% of young people, although only a minority persist and develop into psychotic disorders. It is unclear what characteristics differentiate those with transient from persistent that more likely to be clinical relevance. Aims To investigate how longitudinal profiles experiences, created assessments at three different time points, influenced early life co-occurring factors. Method Using data 8045 individuals birth cohort study, based on...
The genomic architecture of human complex diseases is thought to be attributable single markers, polygenic components and epistatic components. No study has examined the ability tree-based methods detect epistasis in presence a signal. We sought apply decision methods, C5.0 logic regression, under several simulated conditions, varying strength interaction linkage disequilibrium (LD) structure. then applied same phenotype educational attainment large population cohort.LD pruning improved...
Summary Background Evidence suggests that individuals with intellectual disabilities may be at increased risk of affective and non-affective psychotic disorders. However, studies so far have been limited by small selected samples. Moreover, the role early life trauma, a key environmental factor for psychosis, in potential associations is unknown. Methods Using data from Avon Longitudinal Study Parents Children (ALSPAC) birth cohort, we investigated between ID, disorders, experiences...
Abstract Background Given the global burden of disease psychotic disorders and promise benefit from early intervention, there is an imperative to understand developmental trajectories onset experiences clinical disorder improve identification individuals at greatest risk. The aims this study therefore were: 1) describe, for first time, change in incidence general population childhood through adulthood; 2) describe prevalence unmet need at-risk mental states among young adults population; 3)...
Abstract Impaired cognition in schizophrenia is associated with worse functional outcomes. While genetic factors are known to contribute variation schizophrenia, few rare coding variants strong effects have been identified, and the relative from de novo , inherited non-transmitted alleles unknown. We used array exome sequencing data 656 proband-parent trios examine contribution of common school performance, by implication cognitive function, schizophrenia. Probands who performed at were...
Greek Abstract: Πιστό στην παράδοση του ηπειρωτικού δικαίου και ειδικά γαλλικού, το ελληνικό διοικητικό δίκαιο δομήθηκε διαμορφώθηκε με βάση την νομολογία των αρμόδιων δικαστηρίων ειδικότερα ελληνικού Συμβουλίου της Επικρατείας.