Obesity induces low-grade chronic inflammation, manifested by proinflammatory polarization of adipose tissue innate and adaptive resident recruited immune cells that contribute to insulin resistance (IR). The glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone mediates postprandial secretion has anabolic effects on the tissue. Importantly, recent evidence suggested GIP a potential suppressor inflammation in several metabolic models. In this study, we aimed investigate...

Abstract Background Patients with Crohn’s disease (CD) exhibit over-representation of antibody-bound peptides derived from bacterial flagellins. Using longitudinal measurements prior to and during treatment, we aimed assess serum antibody response flagellins related fecal microbial alterations associated treatment. Methods Thirty-nine patients active CD (Harvey-Bradshaw Index [HBI]>4 or calprotectin [FCP]>150μg/g) commencing biologic treatment (Anti-TNF 56.4%, Ustekinumab...

Abstract Background Ulcerative proctitis, a subtype of ulcerative colitis (UC) affecting the rectum, that in vast majority cases is manageable with mesalamine therapy. However, sub-group patients become refractory to such treatment, necessitating advanced systemic therapies. We aimed assess risk factors associated need for therapy proctitis. Methods Demographic and clinical data on proctitis were collected retrospectively single tertiary center during 2010 2024. Proctitis was defined as...

Abstract Background The prevalence of Crohn’s disease (CD) in elderly patients is rising and associated with aging-related challenges. Data on effectiveness safety first line biologic treatment (FLBT) the elderly, are scarce. Our aim was to compare safety, effectiveness, drug persistence FLBT CD. Methods A retrospective, single tertiary center study, including all CD who initiated their at age≥60 years, between 1/1/2010 31/12/2023. Clinical demographic data were extracted adverse events...

Abstract Background Upadacitinib (UPA) and vedolizumab (vedo) are approved for use in patients with moderate to severe ulcerative colitis (UC). Data comparing these therapies as second line Anti-TNF experienced limited yet important aid determining therapeutic positioning. Methods This was a retrospective study conducted between 2015-2024. Patients receiving vedo or UPA at least 14 weeks following anti-TNF failure were included. Clinical response defined decrease the Partial Mayo Score by...

Abstract Background Inflammatory bowel diseases (IBD) are known to be associated with bronchiectasis (BE). However, data detailing the prevalence of BE among patients IBD (IBD-BE), its risk factors, and clinical characteristics limited. Methods This was a single center retrospective study including who visited an unit at tertiary between 2022 2023. Data on prior chest CT scans extracted. Radiologists blinded analyzed all for BE. The overall IBD-BE estimated using multiple imputation...

Abstract Background Approximately 30% of hospitalized patients with acute severe ulcerative colitis (ASUC) may be refractory to systemic glucocorticoid (GC) therapy, administered orally or intravenously necessitating salvage therapy 1. Clinical tools predicting response GC could allow for early initiation thus reducing exposure and improving overall outcomes. However, comparative studies available prognostic scores are limited yield conflicting results 2,3. We aimed determine the best...

Abstract Background Inflammatory Bowel Disease (IBD) most commonly affects women of reproductive age. While considered effective, there are limited data concerning IBD and pregnancy-related outcomes in patients receiving vitro fertilization (IVF). This study compares the characteristics pregnant with who conceived spontaneously those required IVF. Methods retrospective included visited Mom Clinic at Tel Aviv Sourasky Medical Center (TLVMC). The cohort consists two groups - (IBD-spon) or...

Objectives: Preoperative or preanesthesia evaluation is an established practice in patients undergoing surgery. The efficacy of a similar before endoscopic procedures has not yet been determined. At our medical center, with severe comorbidities, deemed at high risk for sedation, were assigned to anesthesiologist-supervised procedure (ASEP). Since late 2016 they are assessed anesthesiology clinic pre-endoscopy. Our objective was compare adverse events (AEs) between these 2 strategies....

The Crohn’s Disease (CD) exclusion diet (CDED) has been shown to induce remission in pediatric and adult patients with CD. In this retrospective cohort study, we describe our real-world experience the CDED at inflammatory bowel disease (IBD) unit of Tel Aviv Medical Center between 2018–2021. CD multiple clinical presentations phenotypes who initiated were included. Indications for treatment, medical nutritional data collected from dietician clinic visits records. Clinical biomarker responses...

One out of 5 patients undergoing coronary angiography has angiographically normal arteries (ANCA). Some them have abnormally slow flow (SCF). The prevalence and causes SCF in these are not clear.We studied 114 consecutive with ANCA. Each angiogram was independently evaluated by 2 physicians unaware all other clinical features the case. Coronary (CF) graded using corrected TIMI Frame Count (cTFC) Clearance (CCFC) methodologies. defined as a cTFC exceeding reported (mean + SD) each three major...

Introduction: Western diet pattern and its food components have been suggested to impact inflammatory bowel diseases (IBDs) clinical course. However, the importance of processing level is uncertain. We aimed evaluate whether intake foods with varying levels associated disease activity in IBD patients. Methods: This cross-sectional study was performed at a tertiary center between August 2019 June 2022. Consecutive adult patients were recruited. Clinical defined using HBI (Crohn’s disease)...

A 58-year-old patient diagnosed with fibromyalgia, irritable bowel syndrome (IBS) and chronic fatigue (CFS), non-responsive to variety of treatments over the years, suffered from significant social occupational disabilities. The was interested in fecal microbiota transplantation (FMT), but given that FMT is not approved for these indications, he used an online protocol screening preparation self-instilled filtrate using enema 6 times. resulted a gradual improvement symptoms 9 months after...

There are inconsistent findings on the association between human non-alcoholic fatty liver disease (NAFLD) and vitamin D, perhaps due to insufficient specificity for gender obesity status. We aimed assess whether serum levels of 25-hydroxyvitamin D associated with unexplained elevated alanine aminotransferase (ALT) in general population across body mass index (BMI) levels.A cross-sectional analysis a population-based cohort nationwide-distribution using electronic medical database. The...

Abstract Background Video capsule endoscopy (VCE) is an effective, noninvasive modality for small bowel (SB) investigation. Its usage in the older adults rising. However, data octa‐nonagenarians regarding diagnostic yield and motility are lacking. Our aim was to evaluate compare safety efficacy of VCE between age subgroups adult patients. Methods This a retrospective study prospectively documented data. All consecutive VCEs patients ≥65 years (01/2010–12/2017) were included. Patients unable...

Abstract Background The Mediterranean Diet (MD) was recently found to be beneficial for Crohn’s Disease CD patients in various stages of the disease. MD emphasizes intake foods that are fiber-rich and high polyphenols, along with avoidance ultra-processed (UPF) a low red meat. Previous data show these dietary patterns could promote gut health mucosal healing. However, little is known about overall adherence its association biochemical activity remission. Therefore, we aimed assess...

Abstract Background Despite the increasing armamentarium of advanced therapies for treatment ulcerative colitis (UC), data comparing effectiveness biologics in early disease are scarce. We aimed to categorize selection patients and assess effectiveness, therapeutic persistence safety used treat UC a bio-naïve patient cohort. Methods This single-center, retrospective study included all who commenced therapy within two years diagnosis between 2012-2023. collected demographic, clinical,...

Abstract Background Acute severe ulcerative colitis (ASUC) affects approximately 20% of patients with (UC). Patients failing initial corticosteroid therapy receive salvage either infliximab (IFX) or calcineurin inhibitors, cyclosporine (CYS) tacrolimus (TAC). We aimed to compare the effectiveness and safety IFX oral inhibitor, TAC, in this setting. Methods This retrospective cohort study included consecutive ASUC, based on Truelove Witts criteria, admitted Tel Aviv Medical Center between...

Abstract Background Patency capsule (PC) ingestion has been proven to be a useful tool in assessing small-bowel patency before of endoscope. However, false positive results un-passed PC due colonic hypomotility/constipation, may wrongfully preclude the use CE this population. Therefore, we aimed evaluate efficacy intense bowel-preparation protocol versus standard clear fluid-diet reduce rates patients with Crohn’s disease (CD) clinical remission. Methods This was bicenter cohort adult (≥18...

Aims Early surgical intervention in Crohn's disease (CD) with inflammatory (B1) phenotype has been shown to be equally successful compared biologic treatment the LIR!C study. On other hand, prospective multicenter CREOLE study demonstrated long term (>4 years) surgery free survival stricturing (B2) CD over 50% of patients, treated medical and endoscopic therapy. This work was aimed compare outcomes between early conservative approach patients presenting penetrating (B3) CD.

Aims Patency capsule (PC) ingestion has been proven to be a useful tool in assessing small-bowel patency before of endoscope. However, false positive results un-passed PC due colonic hypomotility/constipation, may wrongfully preclude the use CE this population. Therefore, we aimed evaluate efficacy intense bowel-preparation protocol versus standard clear fluid-diet reduce rates patients with Crohn's disease (CD) clinical remission.

Aims Side-to-side antiperistaltic ileo-colonic anastomosis (APICA) is wildly used technique in Crohn's disease (CD) patients. Its configuration makes the neo-terminal ileum intubation difficult, and might reduce rates of appropriate scoping, as required for assessment relapse. The isoperistaltic (IPICA) may improve post-surgical endoscopic follow up CD