A5077072265- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Proteoglycans and glycosaminoglycans research
- Adipose Tissue and Metabolism
- Diabetes Treatment and Management
- Endoplasmic Reticulum Stress and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Growth Hormone and Insulin-like Growth Factors
- Metabolism, Diabetes, and Cancer
- Drug Transport and Resistance Mechanisms
- Pediatric Hepatobiliary Diseases and Treatments
- Organ Transplantation Techniques and Outcomes
- Diet and metabolism studies
- Glycosylation and Glycoproteins Research
- HER2/EGFR in Cancer Research
- Cancer Cells and Metastasis
- Liver Disease and Transplantation
- Cell Adhesion Molecules Research
- Lipid metabolism and biosynthesis
- Cancer, Hypoxia, and Metabolism
- Fibroblast Growth Factor Research
- Cancer Research and Treatments
- Mitochondrial Function and Pathology
- Peroxisome Proliferator-Activated Receptors
Tel Aviv Sourasky Medical Center
2013-2024
Tel Aviv University
2011-2024
University of Haifa
2017
Pomeranian Medical University
2010
Turku Centre for Biotechnology
2010
University of Regensburg
2009
Yeshiva University
1993-1999
Albert Einstein College of Medicine
1990-1996
Weizmann Institute of Science
1985-1987
Abstract Endogenous lectins purified from UV‐2237‐IP3 murine fibrosarcoma cells by affinity chromatography consisted of two polypeptide species M r 14,500 (L‐14.5) and 34,000 (L‐34). Antibodies against this material immunoprecipitated the radiolabelled on cell surface as well in cytoplasmic compartment. Similar analyses normal rat embryonal fibroblasts revealed presence only L‐14.5. In contrast, both L‐14.5 L‐34 were found oncogenetransfected, immortalized clones derived cells, untransformed...
Obesity induces low-grade chronic inflammation, manifested by proinflammatory polarization of adipose tissue innate and adaptive resident recruited immune cells that contribute to insulin resistance (IR). The glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone mediates postprandial secretion has anabolic effects on the tissue. Importantly, recent evidence suggested GIP a potential suppressor inflammation in several metabolic models. In this study, we aimed investigate...
Highly sulfated, heparinlike species of heparan sulfate proteoglycans, with glycosaminoglycan chains, are extracellular matrix components that plasma membrane bound in growth-arrested liver cells. Heparins were found to inhibit the growth and lower clonal efficiency HepG2, a minimally deviant, human hepatoma cell line. Heparan sulfates, closely related glycosaminoglycans present around growing cells, had no effect on rate or HepG2 Neither heparins nor sulfates any two poorly differentiated,...
We developed methods for enriching fetal hepatoblasts by combining panning and multiparametric fluorescence-activated cell sorting. In unpurified, dissociated liver suspensions of embryonic age day 15, 3.2% +/- 1.3% 2.5% 0.7% cells expressed albumin alpha-fetoprotein, respectively. The remainder exhibited a hemopoietic, endothelial or stromal phenotype. Cells were panned first with an antibody to red blood remove erythroid then monoclonal antibodies OX-43/OX-44 hemopoietic cells. This...
Abstract Background and Aim: It has been shown in previous studies that hypothyroidism prevents the development of liver fibrosis bile duct ligated rats chronically treated with thioacetamide (TAA). In recent years, regression (occurring spontaneously or during treatment) demonstrated rodent models such as ligation CCl 4 administration. Therefore, present study, potential therapeutic effect on was investigated. Methods: Liver induced by administration TAA (200 mg/kg, i.p., twice weekly) for...
Abstract The bone marrow (BM) contains controlled specialized microenvironments, or niches, that regulate the quiescence, proliferation, and differentiation of hematopoietic stem progenitor cells (HSPC). glucose-dependent insulinotropic polypeptide (GIP) is a gut-derived incretin hormone mediates postprandial insulin secretion has anabolic effects on adipose tissue. Previous studies demonstrated altered microarchitecture in mice deficient for GIP receptor (Gipr−/−), as well expression...
Nicotinamide has been shown to inhibit proliferation and induce apoptosis in a variety of cells. Moreover, nicotinamide treatment attenuates collagen accumulation fibrogenesis the bleomycin model lung fibrosis. We hypothesized that may be useful as an antifibrotic agent liver fibrosis we investigated vitro effect on hepatic stellate cells proliferation, I expression.Transforming growth factor beta1 (TGF-beta1) was used for activation rat HSC-T6 cell line. Apoptosis determined by fluorescence...
Syndecan 1 (CD 138) is a cell surface proteoglycan shed by cells in several pathological conditions, including wound healing. The aim of this study was to test whether CD138 could serve as non-invasive marker for detection liver fibrosis and thereby reduce the need biopsy.An estimation set 134 patients validation 67 with chronic hepatitis C were studied. There 80 normal healthy volunteers. Patients staged according biopsies (Metavir staging, stage F0, n=35; F1, n=40; F2, n=37, F3, n=39; F4,...
Objectives Dipeptidyl peptidase 4 (DPP4) inhibitors, used in obese diabetic patients, reduce inflammation several models. The role of chronic DPP4-deficiency (DPP4-) diet-induced obesity with respect to insulin sensitivity and adipose tissue was investigated. Design Methods Insulin resistance induced by 2 months high fat diet (HFD). In vitro effects glucose-dependent insulinotropic polypeptide (GIP) were assessed explants stromal vascular fraction (SVF). Results HFD-fed DPP4-rats gained...
AIMTo investigate predictors for fibrosis specifically in a high risk population of morbidly obese patients, including detailed evaluation lifestyle. METHODSWe conducted cross-sectional study among patients attending the bariatric clinic at Tel-Aviv Medical Center between years 2013-2014 with body mass index (BMI) above 40 or 35 co-morbidity.Patients serum hepatitis B surface antigen anti-hepatitis C virus antibodies, genetic liver diseases, autoimmune disease alcohol intake (≥ 30 g/d men ≥...
Drug-induced liver injury is an emerging form of acute and chronic disease that may manifest as fatty liver. Amiodarone (AMD), a widely used antiarrhythmic drug, can cause hepatic steatosis by variety mechanisms, not all completely understood. We hypothesized repetitive AMD administration induce lipotoxicity only via effects on the but also adipose tissue. Indeed, induced endoplasmic reticulum (ER) stress in both In tissue, reduced lipogenesis increased lipolysis. Moreover, treatment ER...