Highly sulfated, heparinlike species of heparan sulfate proteoglycans, with glycosaminoglycan chains, are extracellular matrix components that plasma membrane bound in growth-arrested liver cells. Heparins were found to inhibit the growth and lower clonal efficiency HepG2, a minimally deviant, human hepatoma cell line. Heparan sulfates, closely related glycosaminoglycans present around growing cells, had no effect on rate or HepG2 Neither heparins nor sulfates any two poorly differentiated,...

25,27-(Dipropylmorpholinoacetamido)-26,28-dihydroxycalix[4]arene was used as a chemical sensor material in this work. The calix[4]arene LB thin films were prepared onto gold-coated glass and quartz substrates to fabricate film element. Atomic Force Microscopy (AFM) Surface Plasmon Resonance (SPR) techniques characterize all the films. thickness refractive index of can be evaluated with fitted experimental SPR datas. per monolayer determined 1.58 ± 0.04 1.27 0.09 nm, respectively. element...

With the aim to create a library of compounds with potential bioactivities by combining special characteristics two important groups such as nucleobases and carbohydrates, twenty 1,4-disubstituted-triazole nucleosides were synthesized in good yields (80-94%) using copper catalyzed 'Click' reaction between azido-modified pento- or hexopyranoses alkyne-bearing pyrimidine purine nucleobases. Structural elucidation was made assistance spectroscopic techniques FTIR, 1D-, 2D-NMR, ESI-TOFMS. All...

Click chemistry is totally an approach consisting of efficient and reliable reactions that bind two molecular building blocks require no complex purification techniques. The aspire achieving molecules with the desired characteristics behaviour key to click concept. In this concept, in order obtain 1,2,3-triazole products as diversely functionalized molecules, copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction has been widely used for years field materials science, organic synthesis...

Hydrogen bonding and π-π interactions take special part in the enantioselectivity task. In this regard, because of having both hydrogen acceptor donor groups, melamine derivatives become more an issue for enantioselectivity. light such information, triazine-based chiral, fluorescence active novel thiazole L1 L2 were designed synthesized from (S)-(-)-2-amino-1-butanol (1S,2R)-(+)-2-amino-1,2-diphenylethanol. The structural establishment these compounds was made by spectroscopic methods as...

Abstract Herein, a novel calix[4]arene compound, which was modified by the 2‐(2‐aminophenyl)benzothiazole fragment with cyanate recognition function designed based on reporter‐spacer‐receptor sensing system. The construction done via two‐step reaction, and desired sensor 4 characterized FT‐IR, 1 H‐, 13 C‐NMR, fluorescence spectroscopy along HRMS data. candidate showed distinct fluorometric detection means of reporter feature selected benzothiazole constituent. In presence cyanate, gave...

The clinical impact and accessibility of 99m Tc tracers for cancer diagnosis would be greatly enhanced by the availability a new, simple, easy labeling process radiopharmaceuticals. 5-Fluorouracil is an antitumor drug, which has played important role treatment breast carcinoma. In present study, new derivative was synthesized as (1-[{1'-(1''-deoxy-2'',3'':4'',5''-di-O-isopropylidene-β-D-fructopyranose-1''-yl)-1'H-1',2', 3'-triazol-4'-yl}methyl]-5-fluorouracil) (E) radiolabeled with Tc. It...

The volatile composition of 10 endemic Cephalaria (Dipsacaceae) species (Cephalaria gazipashensis, lycica, paphlagonica, elmaliensis, stellipilis, scoparia, isaurica, cilicica, elazigensis var. purpurea and davisiana) was investigated. essential oil mixtures were obtained by steam distillation in a Clevenger-type apparatus. Twenty-eight components identified GC-FID GC-MS techniques. While total percentages ranged from 68.99% to 84.57%, the yields between 38.15% 64.05%. Geraniol, α-cedrene...

Three novel triterpene glycosides (1 - 3), namely lycicoside I, II and cilicicoside were isolated from two different Cephalaria (Dipsacaceae) species along with one known oleanane- iridoit- type of glycoside. The structures these compounds established as 3-O-[β -D-glucopyranosyl( 1→3)-α-L-rhamnopyranosyl(1→4)-β -D-xylopyranosyl(1→4)-β -D-xylopyranosyl]-28-O-[β -Dglucopyranosyl( 1→6)-β -D-glucopyranosyl]-oleanolic acid (1), -D-xylopyranosyl(1→3)-α- L-rhamnopyranosyl(1→4)-β (2) lycica Matthew...

5-Fluorouracil is one of the first line drugs for systemic therapy solid tumors like breast, colorectal, oesophageal, stomach, pancreatic, head and neck. It could be shown that sugars can improve absorption across cell membranes help to bypass some pharmacokinetic problems. Carbohydrates as most common organic molecules are an important issue plant animal metabolisms. They non toxic have duties in body participating DNA RNA synthesis being responsible energy production. In addition, they...

Treatment of D ‐ribose with chloral in the presence acid catalyst gives 1,2‐ O ‐( S )‐trichloroethylidene‐ α ‐ ‐ribofuranose ( 1 ) β ‐ribochloralose). Some derivatives this product were synthesized to be used as an intermediate carbohydrate chemistry. Tricyclic orthoester structure 3 , 77%) was obtained from reaction potassium t ‐butoxide. This novel is expected useful a glycosyl donor formations new ribofuranoside units. 3‐ ‐Methyl‐ribochloralose 5 75% yield via methylation . 5‐...

Abstract Herein, a newly synthesized intermediate, piperazine-based Schiff base (PBSB) gas sensor was fabricated by the condensation of amino functionalized methylpiperazine with aromatic aldehyde containing nitro substituent. This organic material structurally identified spectroscopic techniques such as FTIR, HRMS, 1 H- and 13 C-NMR. The designed candidate explored for its optical response to chlorinated volatile compounds, namely trichloroethylene, dichloromethane chloroform in light...

Abstract The detection of Cu +2 ion chemically is crucial for both the biological and environmental systems. In this study, fluorescent active pyridine‐based diamide thiazole derivative chemosensor N 2 ,N 6 ‐bis(2‐(benzothiazol‐2‐yl)phenyl)pyridine‐2,6‐dicarboxamide ( 3 ) was synthesized characterized successfully. Fluorometric colorimetric properties selectivity sensitivity different metal ions were determined in DMSO/H O (50:50) medium by using fluorescence spectroscopy. exhibited turn on...

In this study novel fluorescence active, two triazine based thiazole derivatives, (2R,2'R)-2,4,6-triamine-N2-[2-(4-benzothiazolyl)phenyl]-N4,N6-[di(butan-1-ol)]-1,3,5-triazine and (1S,1'S,2R,2'R)-2,4,6-triamine-N2-[2-(4-benzothiazolyl)phenyl]-N4,N6-[di(1,2-diphenylethanol)]-1,3,5-triazine with chiral aminoalcohol groups were synthesized conveniently. Their enantiomeric recognition abilities toward the enantiomers of carboxylic acids such as mandelic acid 2-chloromandelic examined in DMSO/H2O...

A fluorescence probe based on calix[4]arene-benzothiazole platform was rationally designed and synthesized for the detection of chlorite ion in aqueous solution. The sensor candidate characterized by such spectroscopic techniques as FTIR, fluorescence, 1H- 13C-NMR along with HRMS analysis. During photophysical characterization experiments, it observed that exhibited weak while its created a strong blue facilitating sensitive detection. Besides, related possessed large Stokes shift (158 nm)...