A5042737050- Pancreatic function and diabetes
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Liver physiology and pathology
- Genetics, Aging, and Longevity in Model Organisms
- Mitochondrial Function and Pathology
- Folate and B Vitamins Research
- Metabolism, Diabetes, and Cancer
- Gut microbiota and health
- Cholinesterase and Neurodegenerative Diseases
- Epigenetics and DNA Methylation
- Cancer Mechanisms and Therapy
- Nutrition, Genetics, and Disease
- Graphene and Nanomaterials Applications
- Drug-Induced Hepatotoxicity and Protection
- Cancer-related cognitive impairment studies
- COVID-19 Clinical Research Studies
- Alzheimer's disease research and treatments
- CRISPR and Genetic Engineering
- Computational Drug Discovery Methods
- Phytochemicals and Antioxidant Activities
- COVID-19 Impact on Reproduction
- Chemotherapy-induced organ toxicity mitigation
Central University of Punjab
2020-2025
RWTH Aachen University
2023-2025
Universitätsklinikum Aachen
2024-2025
University of Central Punjab
2020-2022
National Institute of Pharmaceutical Education and Research
2019-2022
National Institute of Pharmaceutical Education and Research
2018
National Institute of Pharmaceutical Education and Research
2018
Apoptosis is an evolutionarily conserved sequential process of cell death to maintain a homeostatic balance between formation and death. It vital for normal eukaryotic development as it contributes the renewal cells tissues. Further, plays crucial role in elimination unnecessary through phagocytosis prevents undesirable immune responses. regulated by complex signaling mechanism, which driven interactions among several protein families such caspases, inhibitors apoptosis proteins, B-cell...
Doxorubicin (DOX) is a broad-spectrum antibiotic with potent anti-cancer activity. Nevertheless, despite having effective anti-neoplasm activity, its use has been clinically restricted due to life-threatening side effects, such as cardiotoxicity. It evident that betaine anti-oxidant, and anti-inflammatory activity several beneficial decreasing the amyloid-β generation, reducing obesity, improving steatosis fibrosis, activating AMP-activated protein kinase (AMPK). However, whether could...
ABSTRACT Carbon tetrachloride (CCl 4 ), a volatile organic compound, is harmful to multi‐organs, including the liver, lungs, muscles, and kidneys. Methyl donors, such as methionine, choline, betaine, folic acid, are vital one‐carbon metabolism have great potential alleviate oxidative stress inflammation, thus mitigating disease onset. Hence, current study aims examine therapeutic effect of methyl donors against CCl ‐induced nephrotoxicity. Nephrotoxicity was developed in male Sprague Dawley...
Scope The aim of the current study is to evaluate whether l ‐methionine supplementation ( ‐Met‐S) improves type 2 diabetes‐induced alterations in glucose and lipid metabolism by modulating one‐carbon methylation status. Methods Results Diabetes induced male Sprague–Dawley rats using high‐fat diet low dose streptozotocin. At end study, various biochemical parameters, immunoblotting, qRT‐PCR ChIP‐qPCR are performed. first evidence that ‐Met‐S activates p‐AMPK SIRT1, very similar “ metformin ,”...
Recently, the protective effects of a methionine-rich diet on hepatic oxidative stress and fibrosis have been suggested but not adequately studied. We, therefore, hypothesized that L-methionine supplementation would ameliorate progression injury in diet-induced non-alcoholic steatohepatitis (NASH) model aimed to investigate underlying mechanism. NASH was developed male Sprague Dawley rats by feeding them with high-fat-fructose (HFFrD) for 10 weeks. The results demonstrated 16 weeks improved...