A5032094087- T-cell and B-cell Immunology
- Sleep and Wakefulness Research
- Immunotherapy and Immune Responses
- Teaching and Learning Programming
- Immune Cell Function and Interaction
- Sleep and related disorders
- Human Pose and Action Recognition
- Reinforcement Learning in Robotics
- Cytomegalovirus and herpesvirus research
- Circadian rhythm and melatonin
- Model Reduction and Neural Networks
Stanford University
2015-2020
Abstract Individuals with narcolepsy suffer from abnormal sleep patterns due to loss of neurons that uniquely supply hypocretin (HCRT). Previous studies found associations the human leukocyte antigen (HLA)-DQ6 allele and T-cell receptor α (TRA) J24 gene segment also suggested in vitro-stimulated T cells can target HCRT. Here, we present evidence vivo expansion DQ6-HCRT tetramer + /TRAJ24 /CD4 DQ6 individuals without narcolepsy. We identify related TRAJ24 TCRαβ clonotypes encoded by identical...
Abstract The peptide-exchange catalyst, HLA-DM and its inhibitor, HLA-DO control endosomal generation of peptide/class II major histocompatibility protein (MHC-II) complexes; these complexes traffic to the cell surface for inspection by CD4+ T cells. Some evidence suggests that pH influences DO regulation DM function, but also affects stability polymorphic MHC-II proteins, spontaneous peptide loading, DM/MHC-II interactions catalytic activity, imposing challenges on approaches determine...
Abstract CD4+ T cells recognize MHC-II-peptides, whose generation is controlled by HLA-DM and its inhibitor, HLA-DO. Activation of DM-DO-expressing alters DO:DM in favor active DM, but the molecular mechanism(s) underlying this process are unclear. DM known to catalyze exchange MHC-II-associated invariant chain peptides (CLIP) for antigenic peptides. As expected, We identified positive correlation between total CLIP level DO:DM, confirmed sufficient inhibition high cells. Importantly,...