A5008732770- Drug-Induced Adverse Reactions
- Monoclonal and Polyclonal Antibodies Research
- Dendrimers and Hyperbranched Polymers
- Luminescence and Fluorescent Materials
- Food Allergy and Anaphylaxis Research
- Photochromic and Fluorescence Chemistry
- X-ray Diffraction in Crystallography
- Contact Dermatitis and Allergies
- Crystallization and Solubility Studies
- Advanced biosensing and bioanalysis techniques
- Molecular Sensors and Ion Detection
- Porphyrin and Phthalocyanine Chemistry
- Chemical Synthesis and Analysis
- Radical Photochemical Reactions
- RNA Interference and Gene Delivery
- Allergic Rhinitis and Sensitization
- Photochemistry and Electron Transfer Studies
- Advanced Biosensing Techniques and Applications
- Nanoplatforms for cancer theranostics
- Oxidative Organic Chemistry Reactions
- Photoreceptor and optogenetics research
- Mast cells and histamine
- Nonlinear Optical Materials Studies
- Polymer Surface Interaction Studies
- Molecular Junctions and Nanostructures
Universidad de Málaga
2015-2024
Instituto de Investigación Biomédica de Málaga
2015-2024
Andalusian Centre for Nanomedicine and Biotechnology
2015-2024
Junta de Andalucía
2019
Universidad de Huelva
2011-2013
Steacie Institute for Molecular Sciences
2006
University of Minnesota
2006
National Research Council
2006
National Academies of Sciences, Engineering, and Medicine
2006
Laboratoire de Chimie Organique
2002
A set of neutral and anionic carborane derivatives in which the styrenyl fragment is introduced as a fluorophore group has been successfully synthesized characterized. The reaction monolithium salts 1-Ph-1,2-C(2)B(10)H(11), 1-Me-1,2-C(2)B(10)H(11) 1,2-C(2)B(10)H(12) with one equivalent 4-vinylbenzyl chloride leads to formation compounds 1-3, whereas dilithium salt two equivalents gives disubstituted compound 4. closo clusters were degraded using classical method, KOH EtOH, afford...
A novel molecular system with characteristics of an OFF-ON-OFF fluorescence switch was designed to integrate the function a T-latch. In detail, receptor(1)-fluorophore-receptor(2) architecture adopted achieve switching upon addition protons.
Six strongly fluorescent four-coordinate organoboron N,C chelates containing an aryl isoquinoline skeleton were prepared. Remarkably, the fluorescence quantum yields reach values of up to 0.74 in oxygen-free toluene. The strong B-N interaction was corroborated by single-crystal X-ray analysis two dyes. intramolecular charge-transfer character fluorophores evidenced solvatochromism studies and time-dependent DFT calculations at...
A family of stilbene-containing <italic>meta-</italic> and ortho-carborane derivatives substitute at the second carbon cluster atom are synthesised their photophysical properties evaluated.
Modified 1-benzylisoquinoline N-oxides can operate as molecular logic gates. The combination of dual-channel fluorescence emissions and the preferred interaction for selected chemical inputs allows one to design multifunction self-reprogrammable
A dual-channel fluorescent compound runs as a 1 : 2 digital demultiplexer (DEMUX) which can drive single signal (proton) to two different destinations photonic response; each channel be activated independently by careful selection of the excitation wavelength.
Return trip included! The first molecular realization of a reversible logic operation with simple cocktail two classical fluorophores is demonstrated (see figure). Protons and anions, which serve as inputs, trigger independent fluorescence answer signals. Thus, XOR YES gates are straightforward implemented, resulting in behavior. Detailed facts importance to specialist readers published "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made...
We have synthesized several new push-pull oligothiophenes based on the boron dipyrromethene (BODIPY) moiety as electron acceptor and more well-known substituted with N,N-dialkylamino functions to enhance their electron-donor ability. A complete characterization of electronic properties has been carried out; it consists photophysical, electrochemical, vibrational properties. The compounds studied after chemical treatment acids oxidation. In this regard, they can be termed NIR dyes amphoteric...
Allergic reactions towards β-lactam antibiotics pose an important clinical problem. The ability of small molecules, such as a β-lactams, to bind covalently proteins, in process known haptenation, is considered necessary for induction specific immunological response. Identification the proteins modified by β-lactams and elucidation relevance this allergic requires sensitive tools. Here we describe preparation characterization biotinylated amoxicillin analog (AX-B) tool study protein...
Selective reactions to clavulanic acid (CLV) account for around 30% of immediate after administration amoxicillin-CLV. Currently, no immunoassay is available detecting specific IgE CLV, and its recognition in patients with has only been demonstrated by basophil activation testing, however suboptimal sensitivity. The lack knowledge regarding the structure drug that remains bound proteins (antigenic determinant) hampering development vitro diagnostics. We aimed identify antigenic determinants...
Background Allergic reactions to β-lactams are among the most frequent causes of drug allergy and constitute an important clinical problem. Drug covalent binding endogenous proteins (haptenation) is thought be required for activation immune system. Nevertheless, neither nature nor role protein targets involved in this process fully understood. Here, we aim identify novel intracellular haptenation by amoxicillin (AX) their cellular fate. Methods We have treated B lymphocytes with either AX or...
Seven tetracoordinate organoboron fluorophores with heterobiaryl N,O- or N,N-chelate ligands were prepared and photophysically characterized (in toluene). The electronic variation of the heteroaromatic moiety provided a means for fine-tuning UV/vis absorption emission spectra. In most interesting cases, spectra red-shifted to maximum absorbance at wavelengths longer than 500 nm maxima between 620 660 nm. pronounced intramolecular charge-transfer character dyes yielded large Stokes shifts...
A variety of molecule-based logic gates have been developed where chemical and/or physical inputs promote molecular changes integrating up to two and focusing on Boolean interpretations derived from irreversible gates. However, reversible has its uses in quantum computing, low-power CMOS, optical DNA computing. In this paper, we demonstrate the integration three (viz., an XOR gate complementary INHIBIT gates) a single molecule as strategy toward developing molecules that can operate mode by...
Neutral water-soluble aza-BODIPYs are synthesized for imaging applications, demonstrating their potential as NIR emitting fluorescent probes.
A series of boronic acid derived salicylidenehydrazone (BASHY) complexes was prepared and photophysically characterized. The dye platform can be modified by (a) electronic tuning along the cyanine-type axis via modification donor–acceptor pair (b) functional residue. On one hand, approach allows control photophysical parameters such as Stokes shift, emission color, two-photon-absorption (2PA) cross section. resulting dyes show light-up behavior in nonpolar media are characterized high...
A new type of donor-spacer-acceptor podand system has been synthesized and proved as an efficient dual channel fluorosensor for Li+, Mg2+, Ca2+. The known ability the N-oxide function to bind Lewis acids is key step in appearance a emitting charge-transfer (CT) excited state. occurrence this CT state alkaline earth (Mg2+ Ca2+) not metals (Li+) provided fluorosensors.
We analyze the electronic and molecular structures for ground excited states of aromatic terthiophene (3T), quinodimethane 3',4'-dibutyl-5,5' '-bis(dicyanomethylene)-5,5' '-dihydro-2,2':5',2' '-terthiophene (3Q), isologues with middle ring S-oxidized (3TO2, 3QO2). These represent extremes electron rich deficient states, often exhibiting complementary properties. Oxidizing central sulfur atom affects structure, affinity, photophysical properties both pi systems. The consequences 3T include...
Abstract Lack of knowledge the exact chemical structure cephalosporin antigenic determinants has hindered clinical interpretation adverse reactions to these drugs and delayed understanding mechanisms involved in specific recognition binding IgE molecules determinants. We further resolve relationship between activity proposed chemicals, including rational design synthesis haptenic structures. Comparative RAST inhibition studies synthesized revealed that they were recognized by antibodies...