A5072279795- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Parasitic infections in humans and animals
- Synthesis and Biological Evaluation
- Helminth infection and control
- Adenosine and Purinergic Signaling
- Neuroendocrine regulation and behavior
- Toxoplasma gondii Research Studies
- HIV/AIDS drug development and treatment
- Immune Cell Function and Interaction
- Cardiovascular Issues in Pregnancy
- Viral Infections and Immunology Research
- Coccidia and coccidiosis research
- HIV/AIDS Research and Interventions
- Sirtuins and Resveratrol in Medicine
- Bioactive natural compounds
- Circadian rhythm and melatonin
- Neuropeptides and Animal Physiology
- Insects and Parasite Interactions
- Phytochemicals and Antioxidant Activities
- Echinoderm biology and ecology
- Histone Deacetylase Inhibitors Research
- Psychological and Temporal Perspectives Research
University of Buenos Aires
2003-2024
Consejo Nacional de Investigaciones Científicas y Técnicas
1996-2024
Cestodes are a diverse group of parasites, some them being agents neglected diseases. In cestodes, little is known about the functional properties G protein coupled receptors (GPCRs) which have proved to be highly druggable targets in other organisms. Notably, serotoninergic G-protein (5-HT GPCRs) play major roles key functions like movement, development and reproduction parasites.Three 5-HT GPCRs from Echinococcus granulosus Mesocestoides corti were cloned, sequenced, bioinformatically...
Cestode parasites cause neglected diseases, such as echinococcosis and cysticercosis, which represent a significant problem in human animal health. Benzimidazoles praziquantel are the only available drugs for chemotherapy it is therefore important to identify new alternative against cestode parasites. Histone deacetylases (HDACs) validated drug targets treatment of cancer other including diseases. However, knowledge HDACs cestodes very scarce. In this work, we investigated potential develop...
Background Echinococcosis and cysticercosis are neglected tropical diseases caused by cestode parasites (family Taeniidae). Not only there is a small number of approved anthelmintics for the treatment these cestodiases, but also some them not highly effective against larval stages, such that identifying novel drug targets their associated compounds critical. Histone deacetylase (HDAC) enzymes validated in cancers other diseases, have been gaining relevance developing new potential...
C3H/HeN female mice infected with distinct Trypanosoma cruzi subpopulations (RA strain [pantropic/reticulotropic] and K98 clone of the CA-I [myotropic]) show differences both in inflammatory compromise genital tract outcome pregnancy. The group lymphomononuclear infiltrates pelvian fat uterus interstitium, coexisting presence T. DNA, moderate oophoritis, perioophoritis, vasculitis. However, neither parasite DNA nor foci were detected uterus, only mild oophoritis was observed among...
Several factors determine the risk of HIV mother-to-child transmission (MTCT), such as coinfections in placentas from HIV-1 positive mothers with other pathogens. Chagas' disease is one most endemic zoonoses Latin America, caused by protozoan Trypanosoma cruzi. The purpose study was to whether T. cruzi modifies infection placenta at tissue or cellular level.Simple and double infections were carried out on a placental histoculture system (chorionic villi isolated term Chagas negative mothers)...
SUMMARY The proliferative response of CD4 and CD8 T lymphocytes obtained from C3H/HeN mice chronically infected with Trypanosoma cruzi strains that differ in virulence, tropism immunogenicity, was assayed against skeletal muscle, sciatic nerve spinal cord homogenates. Although both the RA strain strongly proliferated nervous system, no muscle antigens detected. K-98 clone (from CA-I strain) showed low all assayed. To determine whether proliferation patterns correlation cell-mediated...
Cestodes are etiological agents of neglected diseases such as echinococcosis and cysticercosis, which major public health problems. Antiparasitic treatment relies on a small number approved drugs, often only partially effective, poorly tolerated require prolonged administration. Thus, the discovery novel potential treatments is critical. The Stevia genus (Asteraceae) includes species that associated with medicinal uses considered source bioactive compounds. Here, we analyzed four South...
Summary Macrophage activation and production of opsonizing antibodies were studied in mice either infected with a lethal reticulotropic Trypanosoma cruzi strain, RA, or non myotropic CA‐I, as well clone, K98 (derived from CA‐I), similar to the parental strain. Measurement macrophage respiratory burst by chemiluminiscence disclosed that T. infection induced an enhancement burst, no matter parasite subpopulation employed. But, while surviving RA was higher than during acute period parasitaemia...
Cestodes are etiological agents of neglected diseases such as echinococcosis and cysticercosis, which major public health problems. Antiparasitic treatment relies on a small number approved drugs, often only partially effective, poorly tolerated require prolonged administration. Thus, the discovery novel potential treatments is critical. The
Background Cells of monocyte/macrophage lineage are one the major targets HIV-1 infection and serve as reservoirs for viral persistence in vivo. These cells also target protozoa Trypanosoma cruzi, causative agent Chagas disease, being most important endemic protozoonoses Latin America. It has been demonstrated vitro that co-infection with other pathogens can modulate HIV replication. However, no studies at cellular level have suggested an interaction between T. cruzi to date....
Tomás Fernández Alfonsoa, Ana María Celentanob, Stella Maris Gonzalez Cappab & Diego A. Golombekca Weill Medical College of Cornell University, New York, YorkUSAb Departamento de Microbiología, Facultad Medicina, Universidad de, Buenos Aires, Argentinac Ciencia y Tecnología, Nacional Quilmes, Argentina
Address: 1National Reference Centre for AIDS, Microbiology Department, School of Medicine, University Buenos Aires, Argentina, 2Laboratory Parasitology, Argentina and 3Endocrinology Service, Clinic Biochemistry Jose de San Martin Hospital, Pharmacy Biochemistry, * Corresponding author
Cestodes are platyhelminth parasites with a wide range of hosts that cause neglected diseases. Neurotransmitter signaling is critical importance for these which lack circulatory, respiratory and digestive systems. For example, serotonin (5-HT) serotonergic G-protein coupled receptors (5-HT GPCRs) play major roles in cestode motility, development reproduction. In previous work, we deorphanized group 5-HT7 type GPCRs from cestodes. However, little known about another 5-HT GPCR, the 5-HT1...
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