A5002010497- Diabetes, Cardiovascular Risks, and Lipoproteins
- ATP Synthase and ATPases Research
- Cholesterol and Lipid Metabolism
- Liver Disease Diagnosis and Treatment
- Lipoproteins and Cardiovascular Health
- Adipokines, Inflammation, and Metabolic Diseases
- Lipid metabolism and biosynthesis
- Adenosine and Purinergic Signaling
- Sphingolipid Metabolism and Signaling
- Lipid metabolism and disorders
- Cancer, Lipids, and Metabolism
- Diet, Metabolism, and Disease
- Lipid Membrane Structure and Behavior
- Frailty in Older Adults
- Nutrition and Health in Aging
- Fatty Acid Research and Health
- Mitochondrial Function and Pathology
- Pancreatic function and diabetes
- Drug Transport and Resistance Mechanisms
- HIV-related health complications and treatments
- Atherosclerosis and Cardiovascular Diseases
- Peroxisome Proliferator-Activated Receptors
- Cardiac Imaging and Diagnostics
- GDF15 and Related Biomarkers
- Cell Adhesion Molecules Research
Inserm
2015-2024
Centre Hospitalier Universitaire de Toulouse
2014-2024
Université de Toulouse
2011-2023
Université Toulouse III - Paul Sabatier
2013-2023
Institut des Maladies Métaboliques et Cardiovasculaires
2014-2023
Weatherford College
2023
Nutrition, Obésité et Risque Thrombotique
2023
Aix-Marseille Université
2023
Maastricht University
2023
University Medical Center
2023
Exosomes are small vesicles secreted from multivesicular bodies, which able to stimulate the immune system leading tumour cell eradication. We have analysed lipids of exosomes either upon stimulation rat mast cells (RBL-2H3 cells), or constitutively human dendritic cells. As compared with parent cells, displayed an enrichment in sphingomyelin, but not cholesterol. Phosphatidylcholine content was decreased, noted disaturated molecular species as phosphatidylethanolamines....
The impact of shift work on cardiovascular disease (CVD) risk factors and metabolic syndrome are not yet completely understood. objectives this study were to evaluate the according two different definitions in a population strictly rotating workers (3×8 h) compared paired counterparts working only day hours, whether itself is determinant after taking into account large panel confusing factors. We conducted cross‐sectional comparing 98 100 regular day‐workers (all subjects had long experience...
High density lipoprotein subfractions with a pre-p migration play key role in the reverse cholesterol transport.The origin of these particles is not yet clearly defined.W e propose to verify possible during catabolism high , (HDL,) by hepatic lipase using two different models.A rat liver perfusion native human HDL, presence heparin induced, after 30 min, formation pre-p, HDL subspecies.Human enriched triacylglycerols, perfused same conditions, led 15 min an enhanced production this pre-P,...
Exosomes are small vesicles secreted by different immune cells and which display anti‐tumoral properties. Stimulation of RBL‐2H3 with ionomycin triggered phospholipase D2 (PLD2) translocation from plasma membrane to intracellular compartments the release exosomes. Although exosomes carry two isoforms PLD, PLD2 was enriched specifically sorted on when overexpressed in cells. PLD activity present clearly increased following overexpression. correlated amount exosome released, as measured FACS....
SHP2 was recently found to down-regulate PI3K activation by dephosphorylating Gab1 but the mechanisms explaining positive role of Gab1/SHP2 pathway in EGF-induced Ras remain ill defined. Substrate trapping experiments now suggest that dephosphorylates other phosphotyrosines located within a central region displaying four YXXP motifs. Because these sites are potential docking motifs for Ras-GAP, we tested whether them facilitate activation. We observed construct preventing recruitment...
Hepatic lipase (HL) is a lipolytic enzyme, synthesized by hepatocytes and found localized at the surface of liver sinusoid capillaries. In humans, enzyme mostly bound onto heparan-sulfate proteoglycans also endothelial cells. HL shares number functional domains with lipoprotein other members gene family. It secreted glycoprotein, remodelling N-linked oligosaccharides appears to be crucial for secretion process, rather than acquisition catalytic activity. present in adrenals ovaries, where it...
Background— The role of inflammation at all stages the atherosclerotic process has become an active area investigation, and there is a notable quest for novel innovative drugs treatment atherosclerosis. lipid kinase phosphoinositide 3-kinase-γ (PI3Kγ) thought to be key player in various inflammatory, autoimmune, allergic processes. These properties expression PI3Kγ cardiovascular system suggest that plays Methods Results— Here, we demonstrate specific inhibitor (AS605240) effective murine...
Dietary cholesterol absorption contributes to a large part of the circulating cholesterol. However, mechanism sterol intestinal uptake is not clearly elucidated. Scavenger receptor class B type I (SR-BI), major component in control homeostasis, expressed intestine, but its role this organ remains unclear. We have generated transgenic mice overexpressing SR-BI primarily intestine by using mouse gene under specific "apoC-III enhancer coupled with apoA-IV promoter." found overexpression respect...
To analyse the relation between various food groups and frequency of insulin resistance syndrome (IRS).A sample 912 men aged 45-64 years was randomly selected. Questionnaires on risk factors a three consecutive day diary were completed. Height, weight, waist circumference, blood pressure measured. A fasting analysed for lipid glucose measurements. The NCEP-ATP-III definition used to assess IRS. Data according quintiles medians dairy products, fish, or cereal grains.The prevalence IRS 23.5%....
A major atheroprotective functionality of high-density lipoproteins (HDLs) is to promote “reverse cholesterol transport” (RCT). In this process, HDLs mediate the efflux and transport from peripheral cells its subsequent liver for further metabolism biliary excretion. We have previously demonstrated in cultured hepatocytes that P2Y13 (purinergic receptor P2Y, G protein–coupled, 13) activation essential HDL uptake but potential as a target RCT has not been documented. Here, we show...
Long-term therapy with protease inhibitors (PI) is associated hypertriglyceridaemia, low high-density lipoprotein (HDL) levels and accumulation of apolipoprotein (apo) E- apo C-III-containing lipoproteins.To evaluate the impact, on this dyslipaemic phenotype, three polymorphisms C-III gene: two an insulin response element one in 3'-region. Apo E genotypes were evaluated also.Sixty consecutive male patients attending HIV follow-up consultation included during a 3-month period. All received at...
Several findings argue for a protective effect of high-density lipoproteins (HDLs) against endothelial dysfunction. The molecular mechanisms underlying this are not fully understood, although recent works suggest that the actions HDL on endothelium initiated by multiple interactions between HDLs (lipid or protein moiety) and cell surface receptors. We previously showed mitochondrial related F(1)-ATPase is receptor their main atheroprotective apolipoprotein (apoA-I). Herein we test hypothesis...
HDL-Cholesterol (HDL-C) is not an accurate surrogate marker to measure the cardioprotective functions of HDL in coronary artery diseases (CAD) patients. Hence, measurement other HDL-related parameters may have prognostic superiority over HDL-C. In this work, we examined predictive value particles profile for long-term mortality CAD patients and compare its informative that HDL-C apoA-I. profiles were measured by nuclear magnetic resonance (NMR) spectroscopy 214 male participants with stable...