A5088114494- Phagocytosis and Immune Regulation
- Immune cells in cancer
- Cell death mechanisms and regulation
- Immune responses and vaccinations
- Erythrocyte Function and Pathophysiology
Yale University
2023-2024
Apoptosis and clearance of apoptotic cells via efferocytosis are evolutionarily conserved processes that drive tissue repair. However, the mechanisms by which recognition regulate repair not fully understood. Here, we use single-cell RNA sequencing to provide a map cellular dynamics during early inflammation in mouse skin wounds. We find pathways receptors elevated fibroblasts immune cells, including resident Lyve1+ macrophages, inflammation. Interestingly, human diabetic foot wounds...
Apoptosis and clearance of apoptotic cells via efferocytosis are evolutionarily conserved processes that drive tissue repair. However, the mechanisms by which recognition regulate repair not fully understood. Here, we use single-cell RNA sequencing to provide a map cellular dynamics during early inflammation in mouse skin wounds. We find pathways receptors elevated fibroblasts immune cells, including resident Lyve1 + macrophages, inflammation. Interestingly, human diabetic foot wounds...
Abstract Defects in apoptotic cell clearance, or efferocytosis, can cause inflammatory diseases and prevent tissue repair due part to inducing a pro-repair transcriptional program phagocytic cells like macrophages. While the cellular machinery metabolic pathways involved efferocytosis have been characterized, precise efferocytic response of macrophages is dependent on identity macromolecular cues cells, complex microenvironment which occurs. Here, we find that undergoing active mid-stage...