A5048424329- Cancer Genomics and Diagnostics
- Glioma Diagnosis and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Single-cell and spatial transcriptomics
- Cancer Cells and Metastasis
- Immune cells in cancer
Leipzig University
2017-2021
Abstract Irradiation is widely used to treat brain tumors, and also create bone marrow (BM) chimeras. BM chimeras are dissect functions origin of microglia blood‐derived mononuclear cells under homeostatic or pathological conditions. This facilitated by the fact that survive irradiation thus regarded radio‐resistant. In this study, we tested whether indeed radio‐resistant looked for potential mechanisms might explain phenomenon. We analyzed radio‐resistance independently their physiological...
Abstract Cancer research requires models closely resembling the tumor in patient. Human tissue cultures can overcome interspecies limitations of animal or loss architecture vitro models. However, analysis slices is often limited to histology. Here, we demonstrate that are also suitable for whole transcriptome sequencing and present a method automated histochemistry slices. Tumor peritumoral from patient with glioblastoma was processed slice cultures, which were treated standard therapy...
One of the major challenges in cancer research is finding models that closely resemble tumors within patients. Human tissue slice cultures are a promising approach to provide model patient's tumor biology ex vivo. Recently, it was shown these slices can be successfully analyzed by whole transcriptome sequencing as well automated histochemistry, increasing their usability preclinical model. Glioblastoma multiforme (GBM) highly malignant brain with poor prognosis and little known about its...