A5075251694- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Analytical Chemistry and Chromatography
- 3D Printing in Biomedical Research
- Crystallization and Solubility Studies
- Analytical Methods in Pharmaceuticals
- Additive Manufacturing and 3D Printing Technologies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Computational Drug Discovery Methods
- Microencapsulation and Drying Processes
- Protein purification and stability
- Pharmaceutical studies and practices
- Statistical and Computational Modeling
- Advancements in Transdermal Drug Delivery
- Material Dynamics and Properties
- Mesoporous Materials and Catalysis
- Injection Molding Process and Properties
- Polymer crystallization and properties
- Electrospun Nanofibers in Biomedical Applications
- Pharmaceutical Quality and Counterfeiting
- Synthesis and properties of polymers
- Pharmaceutical Economics and Policy
- Biosimilars and Bioanalytical Methods
- Proteins in Food Systems
- Medical and Biological Sciences
Jagiellonian University
2016-2025
National Science Center
2023
Collegium Medicum in Bydgoszcz
2019
Because drug quality is the focus for pharmaceutical industry and regulatory agencies, in vitro dissolution test becomes a standard tool characterization of manufactured products.However, results must be expressed mathematical terms; this realized by fitting various models to cumulative curves.The might either mechanistic or empirical.The process requires software (e.g., KinetDS) automation determination possible release mechanisms substances from dosage forms.The FOSS (Free
In this study, the suitability of high-energy ball milling was investigated with aim to vitrify tadalafil (TD) and improve its bioavailability. To achieve goal, pure TD as well binary mixtures composed drug Soluplus (SL) were coprocessed by milling. Modulated differential scanning calorimetry (MDSC) X-ray powder diffraction (XRD) demonstrated that after such coprocessing, crystalline form transformed into an amorphous form. The presence a single glass transition (Tg) for all comilled...
Orodispersible films (ODFs) address the needs of pediatric and geriatric patients people with swallowing difficulties due to fast disintegration in mouth. Typically, they are obtained using solvent casting method, but other techniques such as 3D printing electrospinning have already been investigated. The decision on manufacturing method is crucial importance because it affects film properties. This study aimed compare electrospun ODFs containing aripiprazole polyvinyl alcohol prepared...
Liquisolid (LS) technology is particularly advantageous for poorly water-soluble drugs administered in very low doses because of the improved dissolution rate and superior content uniformity. However, there a lack research papers describing application this concept on an industrial scale. Thus, we present trials conducted to develop tablets containing 0.5 mg water-insoluble dutasteride according LS approach. We divided study into two stages: developing placebo formulation producing...
Even that orodispersible tablets (ODTs) have been successfully used in therapy for more than 20 years, there is still no compendial method of their disintegration time evaluation other the pharmacopoeial test conducted 800-900 mL distilled water. Therefore, several alternative tests relevant to vivo conditions were described by different researchers. The aim this study was compare these methods and correlate them with results. Six series ODTs prepared direct compression. Their mechanical...
Abstract Hydrogel wound dressings are highly effective in the therapy of wounds. Yet, most them do not contain any active ingredient that could accelerate healing. The aim this study was to prepare hydrophilic loaded with an anti-inflammatory compound - trans-resveratrol (RSV) hydrophobic properties. A special attention paid select such a technological strategy both reduce risk irritation at application site and ensure homogeneity final hydrogel. RSV dissolved Labrasol combined aqueous sol...
Due to the possibility of designing various spatial structures, three-dimensional printing can be implemented in production customized medicines. Nevertheless, use these methods for dosage forms requires further optimization, understanding, and development printouts' quality verification mechanisms. Therefore, goal our work was preparation advanced characterization 3D printed orodispersible tablets (ODTs) containing fluconazole, by fused deposition modeling (FDM) method. We prepared analyzed...
Evaluation of macromolecular polymers used as excipients for the preparation hydrodynamically balanced systems (HBS) was carried out. Hard gelatine capsules were filled with polymeric substances belonging to various chemical groups (chitosan, sodium alginate, hydroxypropylmethycellulose—HPMC). The following properties HBS investigated: density, hydration, erosion and floating force. solvent penetration process into visualized using magnetic resonance imaging (MRI) technique. Densities in...
The compendial method of evaluation orodispersible tablets (ODT) is the same disintegration test as for conventional tablets. Since it does not reflect process in oral cavity, alternative methods are proposed that more related to vivo conditions, e.g. modified dissolution paddle apparatus, texture analyzer, rotating shaft CCD camera application, or wetting time and water absorption ratio measurement. In this study, three different co-processed excipients direct compression orally...
The influence of alkaline and the neutral grade magnesium aluminometasilicate as a porous solid carrier for liquid self-emulsifying formulation with ibuprofen is investigated. Ibuprofen dissolved in Labrasol, then this solution adsorbed on silicates. drug to silicate ratio 1:2, 1:4, 1:6, respectively. properties formulations obtained are analyzed, using morphological, porosity, crystallinity, dissolution studies. Three (S-SE) containing Neusilin SG2 six consisting US2 form powder without...
Rational selection of polymers for amorphous drug stabilization is necessary further successful development solid dispersion technology. In this paper, we investigate the effect polymer chain length on inhibition recrystallization. To consider problem, prepared a drug–polymer blend (in 10:1 to ratio) containing bicalutamide (BIC) and polyvinylpyrrolidone (PVP) with different lengths K10, K30, K90. We applied broadband dielectric spectroscopy compare molecular dynamics investigated samples...
Amorphization serves as a strategy for the improvement of poor dissolution characteristics many drug compounds. However, in formulations content polymeric stabilizer is high, which undesirable from perspective future applications. Thus, studying composition-dependent stability amorphous solid dispersions seems to be demanded. In this paper, we describe amorphization ezetimibe, lipid-lowering drug, spray drying process and investigate effect polyvinylpyrrolidone-co-poly(vinyl acetate)...
Taurine bromamine (TauBr), the product of taurine and hypobromous acid (HOBr), exerts anti-inflammatory antibacterial properties. Recently we have shown that Propionibacterium acnes, a potential pathogenic agent acne, is extremely sensitive to TauBr. As topical antibiotics are associated with emergence resistant bacteria, TauBr seems be good candidate for therapy acne vulgaris. In our double blind investigation, efficacy safety 3.5 mM cream was evaluated. 1% Clindamycin gel (Clindacin T),...