A5019605099- Inflammatory mediators and NSAID effects
- Melanoma and MAPK Pathways
- Synthesis and biological activity
- Cancer Mechanisms and Therapy
- Malaria Research and Control
- Computational Drug Discovery Methods
- Synthesis and Catalytic Reactions
- Synthesis of β-Lactam Compounds
- Cancer Immunotherapy and Biomarkers
- Synthesis and Biological Evaluation
- Click Chemistry and Applications
- Pancreatic and Hepatic Oncology Research
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Immune Cell Function and Interaction
- Advanced biosensing and bioanalysis techniques
- T-cell and B-cell Immunology
- Pharmacogenetics and Drug Metabolism
- Phagocytosis and Immune Regulation
- DNA and Nucleic Acid Chemistry
- Drug-Induced Hepatotoxicity and Protection
- Tryptophan and brain disorders
- Phenothiazines and Benzothiazines Synthesis and Activities
- Gut microbiota and health
- interferon and immune responses
- Quinazolinone synthesis and applications
University of Illinois Chicago
2020-2025
University of Washington
2025
University of Wisconsin–Madison
2025
Jesse Brown VA Medical Center
2020-2024
University of Delhi
1992-2024
Central Drug Research Institute
1997-2022
Government of Haryana
2022
Teerthanker Mahaveer Medical College & Research Centre
2022
Council of Scientific and Industrial Research
2018
Guru Ghasidas Vishwavidyalaya
2011-2017
Abstract Polymers have been widely used in agriculture for applications including controlled release of pesticides and other active ingredients. The ability to predict their delivery helps avoid environmental hazards. Macromolecular matrices as carriers agricultural agents, especially pesticides, are reviewed. review focuses on the advantages mechanisms release. It includes biodegradable polymers agriculture, manufacturing methods, degradation kinetics. article also presents a critical...
There has been an upsurge in the number of clinical trials involving chemically modified oligonucleotide-based drug candidates after FDA approval Vitravene, Macugen, and recently, Kynamro. Over years, different types backbone, nucleobase and/or sugar-modified oligonucleotides have synthesized because natural DNA/RNA based pose some limitations, such as poor binding affinity, low degree nuclease resistance, affecting their direct use antisense therapeutics. In this review article, we discuss...
Infection is a major co-morbidity that contributes to impaired healing in diabetic wounds. Although impairments neutrophils have been blamed for this co-morbidity, what causes these and whether they can be overcome, remain largely unclear. Diabetic neutrophils, isolated from individuals, exhibit chemotaxis impairment but peculiar functional has ignored because it appears contradict the clinical findings which blame excessive neutrophil influx as impediment chronic ulcers. Here, we report...
Macrophages are among the most sensitive immune cells because of their phagocytic activity and prone to become dysfunctional or not able perform properly if nanoparticle load increases. We have previously reported that zinc oxide nanoparticles (ZNPs) induce inflammatory responses in macrophages contribute death. Recognition ZNPs by pattern recognition receptors such as toll-like (TLRs) might be a factor initiation these macrophages. Therefore, this study we explored role played TLR6...
Abstract The incidence and mortality of hepatocellular carcinoma (HCC) are on a rise in the Western countries including US, attributed mostly to late detection. Sorafenib has been first-line FDA-approved drug for advanced unresectable HCC almost decade, but with limited efficacy due development resistance. More recently, several other multi-kinase inhibitors (lenvatinib, cabozantinib, regorafenib), human monoclonal antibody (ramucirumab), immune checkpoint (nivolumab, pembrolizumab) have...
Gut microbiota composition can affect tumor microenvironment and its interaction with the immune system, thereby having implications on treatment predictions. This article reviews studies available to better understand how gut microbiomes help system fight cancer. To describe this fact, different mechanisms, approaches of utilizing probiotics improve advancements in cancer will be discussed. Moreover, not only calorie intake but also variety quality diet influence patient’s immunotherapy...
The gut microbiota composition can affect the tumor microenvironment and its interaction with immune system, thereby having implications for treatment predictions. This article reviews studies available to better understand how microbiome helps system fight cancer. To describe this fact, different mechanisms approaches utilizing probiotics improve advancements in cancer will be discussed. Moreover, not only calorie intake but also variety quality of diet influence patients’ immunotherapy...
Malaria is one of the major causes morbidity and mortality in developing countries especially Africa. Although over last fifteen years, prevalence malaria became reduced by half but resistance against artemisinin derivatives its combinations, which are only ray hope to treat resistant set back control efforts key hindrance achieve goal elimination till 2030. In spite these artemisinins precious antimalarials, their action mechanism yet be fully understood. Reactive oxygen species (ROS)...
MAP4K4 is a Ste20 member and reported to play important roles in various pathologies, including cancer. However, the mechanism by which promotes pancreatic cancer not fully understood. It suggested that might function as promoter via specific downstream target(s) an organ-specific manner. Here we identified MLK3 direct target of MAP4K4. The associates with each other, phosphorylates on Thr738 increases kinase activity signaling. phosphorylation cell proliferation, migration, colony...
Van der Woude syndrome (VWS) is an autosomal dominant disorder characterized by lower lip pits and orofacial clefts (OFCs). With a prevalence of approximately 1 in 35,000 live births, it the most common form syndromic clefting may account for ~2% all OFCs. The majority VWS attributed to genetic variants IRF6 (~70%) or GRHL3 (~5%), leaving up 25% individuals with without molecular diagnosis. Both function transcriptional regulatory network governing differentiation periderm, single layer...
Pancreatic Ductal Adenocarcinoma (PDAC) remains remarkably lethal, with a 5-year survival rate of less than 12%. Due to its widespread resistance conventional therapy, PDAC is expected be the second most common cause cancer-related death in United States by 2030. One major impediments therapeutic failure presence an immunosuppressive tumor microenvironment (TME). We examined function Mitogen-activated protein kinases (MAPKs) upstream member, MAP4K4, PDAC-TME and tested efficacies MAP4K4...
Abstract The canonical Wnt/β-catenin signaling pathway is important for normal liver growth and development, abnormal activation of which can lead to various pathologies, including hepatocellular carcinoma (HCC). Usually, β-catenin regulated by a degradation complex that includes adenomatous polyposis coli, Axin, Glycogen Synthase Kinase β, Casein kinase 1α. Mutations itself other genes regulating this cause aberrant axis. We have reported earlier Mixed Lineage 3 (MLK3), member the MAPK...