A5066364983- Lysosomal Storage Disorders Research
- Privacy, Security, and Data Protection
- Biomedical Research and Pathophysiology
- Privacy-Preserving Technologies in Data
- COVID-19 epidemiological studies
- Erythrocyte Function and Pathophysiology
- Biosensors and Analytical Detection
- Data-Driven Disease Surveillance
- SARS-CoV-2 detection and testing
- Misinformation and Its Impacts
- Calcium signaling and nucleotide metabolism
- Insect Utilization and Effects
- COVID-19 Clinical Research Studies
- Neurobiology and Insect Physiology Research
- Genetic Neurodegenerative Diseases
- Lipid Membrane Structure and Behavior
- Aquaculture Nutrition and Growth
- Amino Acid Enzymes and Metabolism
- Dental Research and COVID-19
- Endoplasmic Reticulum Stress and Disease
- Proteins in Food Systems
- Mitochondrial Function and Pathology
- Retinal Development and Disorders
- Transgenic Plants and Applications
University of California, San Diego
2022-2025
Cardiff University
2020-2021
Background The ongoing pandemic has placed an unprecedented strain on global society, health care, governments, and mass media. Public dissemination of government policies, medical interventions, misinformation been remarkably rapid largely unregulated during the COVID-19 pandemic, resulting in increased misinterpretations, miscommunication, public panic. Being first full-scale digital age, presented novel challenges pertinent to advice, spread news misinformation, trade-off between...
Friedreich ataxia (FRDA) is a multisystemic, autosomal recessive disorder caused by homozygous GAA expansion mutation in the first intron of frataxin ( FXN ) gene. mitochondrial protein critical for iron-sulfur cluster biosynthesis and deficiency impairs electron transport chain functions iron homeostasis within organelle. Currently, there no effective treatment FRDA. We have previously demonstrated that single infusion wild-type hematopoietic stem progenitor cells (HSPCs) resulted...
Abstract Macronutrients, comprising carbohydrates, proteins and lipids, underpin many ecological processes, but their quantification in studies is often inaccurate laborious, requiring large investments of time bulk samples, which make individual‐level impossible. This study presents Macronutrient Extraction Determination from Invertebrates (MEDI), a protocol for the direct, rapid relatively low‐cost determination macronutrient content single small macroinvertebrates. Macronutrients were...
Cystinosis is a systemic lysosomal storage disease resulting from defective CTNS gene, leading to the accumulation of cystine in all organs. Despite ubiquitous expression cystinosin, renal Fanconi syndrome (FS) first manifestation cystinosis that presents early life patients while other complications appear years later. Additionally, reduction therapy, cysteamine, does not prevent FS. While matter still unresolved, it apparent specific function(s) cystinosin proximal tubular cells (PTCs)...
Mucopolysaccharidosis type IIIC (MPS IIIC) is a severe neurodegenerative lysosomal storage disease caused by the loss-of-function of transmembrane protein acetyl-CoA: heparan-α-glucosamine N -acetyltransferase. MPS characterized accumulation glycosaminoglycan (GAG) heparan sulfate. There no treatment for this disease. We generated new mouse model and confirmed phenotypes such as GAG accumulation, splenomegaly, neurological defects, presence disease-specific non-reducing end carbohydrates. To...
Good's buffers are commonly used for cell culture and, although developed to have minimal no biological impact, they cause alterations in cellular processes such as autophagy and lysosomal enzyme activity. Using Chinese hamster ovary cells induced pluripotent stem cell-derived neurons, this study explores the effect of zwitterionic buffers, specifically HEPES, on volume Ca2+ levels. Certain lead expansion reduced Ca2+. Care should be taken when selecting growth media avoid detrimental...
Mucopolysaccharidosis type IIIC (MPSIIIC) is a severe neurodegenerative lysosomal storage disease (LSD) caused by loss-of-function of the transmembrane protein Heparan-𝛼-glucosamine N-acetyltransferase (HGSNAT). MPS characterized accumulation glycosaminoglycan (GAG) heparan sulfate (HS). There no treatment for this disease. We generated new mouse model and confirmed phenotypes such as GAG accumulation, splenomegaly, neurological defects, presence specific non-reducing end carbohydrates. To...
The COVID-19 pandemic necessitated rapid real-time surveillance of epidemiological data to advise governments and the public, but accuracy these depends on myriad auxiliary assumptions, not least accurate reporting cases by public. Wastewater monitoring has emerged internationally as an objective means for assessing disease prevalence with reduced latency less dependence public vigilance, reliability, engagement. How interest aligns personal testing wastewater is, however, very poorly characterized.
<sec> <title>BACKGROUND</title> The ongoing pandemic has placed an unprecedented strain on global society, health care, governments, and mass media. Public dissemination of government policies, medical interventions, misinformation been remarkably rapid largely unregulated during the COVID-19 pandemic, resulting in increased misinterpretations, miscommunication, public panic. Being first full-scale digital age, presented novel challenges pertinent to advice, spread news misinformation,...
<sec> <title>BACKGROUND</title> The COVID-19 pandemic necessitated rapid real-time surveillance of epidemiological data to advise governments and the public, but accuracy these depends on myriad auxiliary assumptions, not least accurate reporting cases by public. Wastewater monitoring has emerged internationally as an objective means for assessing disease prevalence with reduced latency less dependence public vigilance, reliability, engagement. How interest aligns personal testing wastewater...