A5115604736- RNA modifications and cancer
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Genital Health and Disease
- Advanced biosensing and bioanalysis techniques
- Monoclonal and Polyclonal Antibodies Research
- Renal and related cancers
- Insect symbiosis and bacterial influences
- Multiple Myeloma Research and Treatments
- Mosquito-borne diseases and control
- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- CAR-T cell therapy research
- Graphene and Nanomaterials Applications
- Cervical Cancer and HPV Research
- Colorectal and Anal Carcinomas
- Single-cell and spatial transcriptomics
- Kruppel-like factors research
- Peptidase Inhibition and Analysis
- Invertebrate Immune Response Mechanisms
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Diagnosis and Treatment
- Carbon and Quantum Dots Applications
- Reproductive Biology and Fertility
- DNA Repair Mechanisms
Kelun Group (China)
2025
First Affiliated Hospital Zhejiang University
2023-2024
Zhejiang University
2023-2024
Shanghai Clinical Research Center
2023-2024
Institute of Genetics and Developmental Biology
2022-2024
University of Chinese Academy of Sciences
2024
Chinese Academy of Sciences
2022-2023
Anhui Agricultural University
2023
Capital Normal University
2016
While a few works have shown that Mettl3 plays oncogenic roles in hepatocellular carcinoma (HCC), its function early HCC tumorigenesis remains unclear. In Mettl3flox/flox; Alb-Cre knockout mice, loss leads to aberrant hepatocyte homeostasis and liver damage. Importantly, deletion dramatically accelerates various mouse models. Depletion of adult Mettl3flox/flox mice through TBG-Cre administration also enhances tumor development, while overexpression inhibits hepatocarcinogenesis....
Osimertinib, a third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), has become cornerstone in the treatment of EGFR-mutated (EGFRm) non-small cell lung cancer (NSCLC), with notable efficacy against common EGFR mutations, T790M resistance mutation, and treating brain metastases. Despite its benefits, to Osimertinib monotherapy, especially due secondary mutations such as C797S, poses major clinical challenge. This study compares outcomes monotherapy versus...
Aspirin, also known as acetylsalicylic acid, is widely consumed a pain reliever and an anti-inflammatory well anti-platelet agent. Recently, our studies using the animal model of Drosophila demonstrated that dietary supplementation aspirin renovates age-onset intestinal dysfunction delays organismal aging. Nevertheless, it remains probable plays functional roles in other biological activities, for instance antiviral defense reactions. Intriguingly, we observed replications several types...
RAD51 is related to the bacterial RecA protein and best known for its role in homologous recombination-mediated repair of DNA damage. Here, we report an unexpected function maintenance methylation genomic DNA, a that separable from recombination. First, it acts as inhibitor E3 ubiquitin ligase UHRF1. Deficiency causes excessive ubiquitination degradation methyltransferase DNMT1, leading loss global methylation. Second, helps UHRF1 monoubiquitinate histone H3 generate DNMT1 recruiting signal....
The surface of graphene oxide was modified by bis(3-aminopropyl)-terminated polyethylene glycol to produce a composite graphene–polyethylene glycol. oxide/polyethylene maximum absorption peak in the ultraviolet–visible spectrum redshifted, and transmission electron microscope images showed that cleaved into small nanosheets form dispersibility physiological solution higher than for oxide. optimum used as quencher fluorescence resonance energy transfer aptasensor determination lysozyme...
ABSTRACT The determinants of persistent human papillomavirus (HPV) infection remain largely unknown, and existing studies have predominantly focused on the female population. Individual genetic background may influence persistence HPV infection, we evidence overall among immunodeficiency virus (HIV)‐positive males are very limited. We conducted a genome‐wide association study (GWAS) to identify single nucleotide polymorphisms (SNPs) associated with anal persistence, based cohort designed...