A5042720738- Congenital Heart Disease Studies
- Cancer Cells and Metastasis
- Cardiac pacing and defibrillation studies
- Infective Endocarditis Diagnosis and Management
- Digestive system and related health
- Hedgehog Signaling Pathway Studies
- Cardiac Arrhythmias and Treatments
- 3D Printing in Biomedical Research
- Gastrointestinal disorders and treatments
- Intestinal Malrotation and Obstruction Disorders
- Epigenetics and DNA Methylation
- Intestinal and Peritoneal Adhesions
- Pluripotent Stem Cells Research
- Cardiac Valve Diseases and Treatments
- Coronary Artery Anomalies
- Streptococcal Infections and Treatments
- Polysaccharides and Plant Cell Walls
- Transplantation: Methods and Outcomes
- Cellular Mechanics and Interactions
- CRISPR and Genetic Engineering
- Antimicrobial Resistance in Staphylococcus
Children's Hospital of Philadelphia
2024
University of Colorado Anschutz Medical Campus
2021-2022
University of Colorado Denver
2021-2022
University of Michigan
2015-2016
Ann Arbor Center for Independent Living
2016
In the intestine, finger-like villi provide abundant surface area for nutrient absorption. During murine villus development, epithelial Hedgehog signals promote aggregation of sub-epithelial mesenchymal clusters that drive emergence. Clusters arise first dorsally and proximally spread over entire intestine within 24-hours, but mechanism driving this pattern in is unknown. chick, driver cluster tensile force from developing smooth muscle, which generates deep longitudinal folds locally...
We demonstrate that dissociated human pluripotent stem cells (PSCs) are intrinsically programmed to form lumens. PSCs two-cell cysts with a shared apical domain within 20 hr of plating; these collapse monolayers after 5 days. Expression pluripotency markers is maintained throughout this time. In cysts, an domain, marked by EZRIN and atypical PKCζ, surrounded apically targeted organelles (early endosomes Golgi). Molecularly, actin polymerization, regulated ARP2/3 mammalian diaphanous-related...
Murine intestinal villi are rapidly demarcated by patterned intraepithelial forces that induced mesenchymal cell clusters and accelerated division.
Abstract There are a growing number of adult patients palliated to Fontan circulation. As these age, many develop symptomatic heart failure (d’Udekem et al in Circulation 130:S32–S38, 2014) that is exacerbated by acquired comorbidities such as obesity and hypertension. Increased body mass index (BMI) adiposity have been associated with worse hemodynamics clinical outcomes (Yogeswaran J Am Hear Assoc: Cardiovasc Cerebrovasc Dis 12:e026732, 2023). Recently, glucagon-like peptide-1 (GLP-1)...
Introduction: There are limited data on the medications taken by patients with Fontan circulation in adult congenital heart disease (ACHD) clinics. Research Questions/Hypothesis: We aim to describe type and frequency of prescribed adults hypothesize that higher medication burden have worse outcomes. Methods: conducted a retrospective cohort study followed an outpatient ACHD clinic between 2009 2023. Demographics, clinical variables, all cardiac were abstracted. The outcome interest was...
Introduction: More patients with Fontan circulation are surviving into adulthood and transitioning to adult congenital heart disease (ACHD) care. There limited long-term outcome data in these patients. Research Questions: We sought describe a cohort of adults determine patient characteristics associated survival. Methods: A retrospective review followed our ACHD clinic between 2009 2023 was performed. The interest transplant-free Survival analysis performed explore association factors time...
Adolescents and adults with CHD have increased risk for IE because of anatomic anomalies burden intracardiac prosthetic material. There are significant challenges in determining primary surgical or medical management along limited guidelines to determine management.
Infective endocarditis (IE) occurs more frequently in individuals living with congenital heart disease, often high morbidity and mortality. Although gram-positive bacterial infections commonly cause IE, prosthetic valves are a known risk factor for fungal IE. We report case of pulmonary valve Candida parapsilosis IE 58-year-old male repaired tetralogy Fallot. He presented fatigue, petechiae, hematochezia. had severe thrombocytopenia from idiopathic/immune purpura, which resolved steroids...