A5035712218- Neuroscience and Neuropharmacology Research
- Attention Deficit Hyperactivity Disorder
- Neurotransmitter Receptor Influence on Behavior
- Ion channel regulation and function
- Memory and Neural Mechanisms
- Neuroscience and Neural Engineering
- Neural dynamics and brain function
- Receptor Mechanisms and Signaling
- Photoreceptor and optogenetics research
- Olfactory and Sensory Function Studies
- Functional Brain Connectivity Studies
- Neuroscience of respiration and sleep
- Anesthesia and Neurotoxicity Research
- Amino Acid Enzymes and Metabolism
- Nicotinic Acetylcholine Receptors Study
- Sleep and Wakefulness Research
- Molecular Sensors and Ion Detection
- Retinal Development and Disorders
- Neurogenesis and neuroplasticity mechanisms
- Epilepsy research and treatment
- Aldose Reductase and Taurine
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Psychedelics and Drug Studies
- RNA Interference and Gene Delivery
Universidad de Santiago de Chile
2008-2023
Max Planck Institute of Psychiatry
1987-1996
Pontificia Universidad Católica de Chile
1995
Stony Brook University
1994
State University of New York
1994
Max Planck Society
1981-1992
Max Planck Institute for Brain Research
1981-1987
Ruhr University Bochum
1983
Abstract: The effect of N ‐methyl‐ d , l ‐aspartic acid (NMA) on extracellular amino acids was studied in the rabbit hippocampus with brain dialysis technique. Administration 0.5 or 5 m M NMA caused a concentration‐dependent liberation taurine and phosphoethanolamine (PEA). Taurine increased by 1,200% PEA 2,400% during perfusion whereas most other rose 20–100%. appeared to be receptor‐mediated, as coperfusion D‐2‐amino‐5‐phosphonovaleric curtailed response some 90%. NMA‐stimulated release...
Zn2+ is an essential ion that stored in and co-released from glutamatergic synapses it modulates neurotransmitter receptors involved long-term potentiation (LTP). However, the mechanism(s) underlying Zn2+-induced modulation of LTP remain(s) unclear. As purinergic P2X are relevant targets for action, we have studied their role by CA1 region rat hippocampal slices. Induction presence revealed a biphasic effect – 5–50 μm enhanced induction, whereas 100–300 inhibited LTP. The involvement...
In ADHD treatment, methylphenidate (MPH) is the most frequently used medication. The present work provides evidence that MPH restored behavioral impairments and neuroplasticity due to changes in AMPAR subunit composition distribution, as well maturation of dendritic spines, a prenatal nicotine exposure (PNE) mouse model. PNE animals controls were given single oral dose (1 mg/kg), their behavior was tested for attention, hyperactivity, working memory. Long-term potentiation (LTP) induced...
Abstract We examined the effect of corticosterone (10 ‐7 to 10 ‐5 M) on membrane properties and postsynaptic potentials, by means intracellular recordings from neocortical hippocampal CA1 pyramidal neurons intact adult rat in vitro . Corticosterone reduced both early late components orthodromically‐evoked inhibitory potential structures. The glucocorticoid receptor antagonist RU 38486 ‐6 prevented this hippocampus. In hippocampal, but not neurons, a depolarizing transient evoked current step...
Abstract The neuroactive steroid 5α‐pregnane‐3α,21‐diol‐20‐one (5α‐tetrahydrodeoxycorticosterone; 5α‐THDOC) has been shown to potentiate GABA‐induced chloride currents in cell cultures and subcellular preparations. In this study, we recorded from pyramidal neurons an vitro slice preparation of the adult rat frontal neocortex using intracellular microelectrodes. 5α‐THDOC (10 μM) increased prolonged inhibitory postsynaptic potential (IPSP). mean maximal synaptic conductance early, GABA A...